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- Publisher Website: 10.1016/j.atherosclerosis.2012.12.013
- Scopus: eid_2-s2.0-84873473168
- PMID: 23298824
- WOS: WOS:000314785400023
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Article: Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes
Title | Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes |
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Authors | |
Keywords | Endothelial function Type 2 diabetes mellitus Vitamin D |
Issue Date | 2013 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis |
Citation | Atherosclerosis, 2013, v. 227 n. 1, p. 140-146 How to Cite? |
Abstract | Background:
Suboptimal vitamin D status is associated with endothelial dysfunction and an increased risk of cardiovascular diseases but it is unclear whether vitamin D supplementation is beneficial. The aim was to investigate the effect of vitamin D supplementation on endothelial function in patients with type 2 diabetes mellitus (DM).
Methods:
In a double-blind, placebo-controlled trial, we randomized 100 type 2 DM patients to vitamin D supplement (5000 IU/day, n = 50) or placebo (controls, n = 50) for 12 weeks. Assessment of vascular function with brachial artery flow-mediated dilatation (FMD), circulating levels of endothelial progenitor cells (EPCs) and brachial-ankle pulse wave velocity, and metabolic parameter, high-sensitivity C-reactive protein (hsCRP) and oxidative stress markers were performed before and after the supplementation.
Results:
After 12 weeks, vitamin D treated patients had significant increases in serum 25-hydroxyvitamin D [25(OH)D] concentration (treatment effect 34.7 ng/mL, 95% CI 26.4–42.9, P < 0.001) and serum ionized calcium (treatment effect 0.037 mmol/L, 95% CI 0.007–0.067, P = 0.018); decreased serum parathyroid hormone concentration (treatment effect −0.55 pmol/L, 95% CI −1.08 to −0.02, P = 0.042) compared to patients who received placebo. Nevertheless, vitamin D supplementation did not improve vascular function as determined by FMD, circulating EPC count or baPWV (all P > 0.05). Furthermore, hsCRP, oxidative stress markers, low- and high-density lipoprotein and glycated hemoglobin were also similar between two groups (all P > 0.05).
Conclusion:
In patients with type 2 DM, 12 weeks oral supplementation of vitamin D did not significantly affect vascular function or serum biomarkers of inflammation and oxidative stress.
Clinical trial number:
HKCTR-867, www.hkclinicaltrials.com. |
Persistent Identifier | http://hdl.handle.net/10722/182005 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.461 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yiu, YF | en_US |
dc.contributor.author | Yiu, KH | en_US |
dc.contributor.author | Siu, DCW | en_US |
dc.contributor.author | Chan, YH | en_US |
dc.contributor.author | Li, SW | en_US |
dc.contributor.author | Wong, LY | en_US |
dc.contributor.author | Lee, SW | en_US |
dc.contributor.author | Tam, S | en_US |
dc.contributor.author | Wong, EW | en_US |
dc.contributor.author | Lau, CP | en_US |
dc.contributor.author | Cheung, BMY | en_US |
dc.contributor.author | Tse, HF | en_US |
dc.date.accessioned | 2013-04-17T07:17:08Z | - |
dc.date.available | 2013-04-17T07:17:08Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Atherosclerosis, 2013, v. 227 n. 1, p. 140-146 | en_US |
dc.identifier.issn | 0021-9150 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/182005 | - |
dc.description.abstract | Background: Suboptimal vitamin D status is associated with endothelial dysfunction and an increased risk of cardiovascular diseases but it is unclear whether vitamin D supplementation is beneficial. The aim was to investigate the effect of vitamin D supplementation on endothelial function in patients with type 2 diabetes mellitus (DM). Methods: In a double-blind, placebo-controlled trial, we randomized 100 type 2 DM patients to vitamin D supplement (5000 IU/day, n = 50) or placebo (controls, n = 50) for 12 weeks. Assessment of vascular function with brachial artery flow-mediated dilatation (FMD), circulating levels of endothelial progenitor cells (EPCs) and brachial-ankle pulse wave velocity, and metabolic parameter, high-sensitivity C-reactive protein (hsCRP) and oxidative stress markers were performed before and after the supplementation. Results: After 12 weeks, vitamin D treated patients had significant increases in serum 25-hydroxyvitamin D [25(OH)D] concentration (treatment effect 34.7 ng/mL, 95% CI 26.4–42.9, P < 0.001) and serum ionized calcium (treatment effect 0.037 mmol/L, 95% CI 0.007–0.067, P = 0.018); decreased serum parathyroid hormone concentration (treatment effect −0.55 pmol/L, 95% CI −1.08 to −0.02, P = 0.042) compared to patients who received placebo. Nevertheless, vitamin D supplementation did not improve vascular function as determined by FMD, circulating EPC count or baPWV (all P > 0.05). Furthermore, hsCRP, oxidative stress markers, low- and high-density lipoprotein and glycated hemoglobin were also similar between two groups (all P > 0.05). Conclusion: In patients with type 2 DM, 12 weeks oral supplementation of vitamin D did not significantly affect vascular function or serum biomarkers of inflammation and oxidative stress. Clinical trial number: HKCTR-867, www.hkclinicaltrials.com. | - |
dc.language | eng | en_US |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis | en_US |
dc.relation.ispartof | Atherosclerosis | en_US |
dc.subject | Endothelial function | - |
dc.subject | Type 2 diabetes mellitus | - |
dc.subject | Vitamin D | - |
dc.title | Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | en_US |
dc.identifier.email | Siu, DCW: cwdsiu@hkucc.hku.hk | en_US |
dc.identifier.email | Wong, LY: navywong@hkucc.hku.hk | en_US |
dc.identifier.email | Lau, CP: cplau@hku.hk | en_US |
dc.identifier.email | Cheung, BMY: mycheung@hku.hk | en_US |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | en_US |
dc.identifier.authority | Yiu, KH=rp01490 | en_US |
dc.identifier.authority | Siu, DCW=rp00534 | en_US |
dc.identifier.authority | Cheung, BMY=rp01321 | en_US |
dc.identifier.authority | Tse, HF=rp00428 | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2012.12.013 | - |
dc.identifier.pmid | 23298824 | - |
dc.identifier.scopus | eid_2-s2.0-84873473168 | - |
dc.identifier.hkuros | 214028 | en_US |
dc.identifier.volume | 227 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 140 | en_US |
dc.identifier.epage | 146 | en_US |
dc.identifier.isi | WOS:000314785400023 | - |
dc.identifier.issnl | 0021-9150 | - |