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Article: Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection

TitleTargeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection
Authors
KeywordsAntivirals
Cyclooxygenase-2 inhibitors
Immunomodulators
Influenza
Neuraminidase inhibitor resistance
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral
Citation
Antiviral Research, 2012, v. 96 n. 3, p. 391-404 How to Cite?
AbstractInfluenza epidemics and pandemics are constant threats to human health. The application of antiviral drugs provides an immediate and direct control of influenza virus infection. At present, the major strategy for managing patients with influenza is through targeting conserved viral proteins critical for viral replication. Two classes of conventional antiviral drugs, the M2 ion channel blockers and the neuraminidase inhibitors, are frequently used. In recent years, increasing levels of resistance to both drug classes has become a major public health concern, highlighting the urgent need for the development of alternative treatments. Novel classes of antiviral compounds or biomolecules targeting viral replication mechanism are under development, using approaches including high-throughput small-molecule screening platforms and structure-based designs. In response to influenza virus infection, host cellular mechanisms are triggered to defend against the invaders. At the same time, viruses as obligate intracellular pathogens have evolved to exploit cellular responses in support of their efficient replication, including antagonizing the host type I interferon response as well as activation of specific cellular pathways at different stages of the replication cycle. Numerous studies have highlighted the possibility of targeting virus-host interactions and host cellular mechanisms to develop new treatment regimens. This review aims to give an overview of current and novel concepts targeting the virus and the host for managing influenza.
Persistent Identifierhttp://hdl.handle.net/10722/181890
ISSN
2015 Impact Factor: 4.909
2015 SCImago Journal Rankings: 2.080
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, MY-
dc.contributor.authorYen, H-
dc.date.accessioned2013-03-21T02:52:33Z-
dc.date.available2013-03-21T02:52:33Z-
dc.date.issued2012-
dc.identifier.citationAntiviral Research, 2012, v. 96 n. 3, p. 391-404-
dc.identifier.issn0166-3542-
dc.identifier.urihttp://hdl.handle.net/10722/181890-
dc.description.abstractInfluenza epidemics and pandemics are constant threats to human health. The application of antiviral drugs provides an immediate and direct control of influenza virus infection. At present, the major strategy for managing patients with influenza is through targeting conserved viral proteins critical for viral replication. Two classes of conventional antiviral drugs, the M2 ion channel blockers and the neuraminidase inhibitors, are frequently used. In recent years, increasing levels of resistance to both drug classes has become a major public health concern, highlighting the urgent need for the development of alternative treatments. Novel classes of antiviral compounds or biomolecules targeting viral replication mechanism are under development, using approaches including high-throughput small-molecule screening platforms and structure-based designs. In response to influenza virus infection, host cellular mechanisms are triggered to defend against the invaders. At the same time, viruses as obligate intracellular pathogens have evolved to exploit cellular responses in support of their efficient replication, including antagonizing the host type I interferon response as well as activation of specific cellular pathways at different stages of the replication cycle. Numerous studies have highlighted the possibility of targeting virus-host interactions and host cellular mechanisms to develop new treatment regimens. This review aims to give an overview of current and novel concepts targeting the virus and the host for managing influenza.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral-
dc.relation.ispartofAntiviral Research-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Antiviral Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Antiviral Research, [VOL 96, ISSUE 3, 2012] DOI 10.1016/j.antiviral.2012.09.013-
dc.subjectAntivirals-
dc.subjectCyclooxygenase-2 inhibitors-
dc.subjectImmunomodulators-
dc.subjectInfluenza-
dc.subjectNeuraminidase inhibitor resistance-
dc.titleTargeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infectionen_US
dc.typeArticleen_US
dc.identifier.emailLee, MY: myleesuki01@yahoo.com.hk-
dc.identifier.emailYen, H: hyen@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.antiviral.2012.09.013-
dc.identifier.pmid23022351-
dc.identifier.scopuseid_2-s2.0-84869139385-
dc.identifier.hkuros217325-
dc.identifier.volume96-
dc.identifier.issue3-
dc.identifier.spage391-
dc.identifier.epage404-
dc.identifier.isiWOS:000312518100015-
dc.publisher.placeNetherlands-

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