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postgraduate thesis: In vitro and in vivo study of plasma immersion ion implantation (PIII)treated polyetheretherketone (PEEK)

TitleIn vitro and in vivo study of plasma immersion ion implantation (PIII)treated polyetheretherketone (PEEK)
Authors
Advisors
Issue Date2013
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Chong, Y. [莊瑜華]. (2013). In vitro and in vivo study of plasma immersion ion implantation (PIII) treated polyetheretherketone (PEEK). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4985883
AbstractPolyetheretherketone (PEEK), a polymer with mechanical strength comparable to human bone, is gaining popularity in the orthopedic field because it can potentially relieve the clinical complications, such as stress shielding effect and inevitable implantation failure, which are caused by the mismatch of the mechanical strength between the current metallic implants and the implantation sites. However, it is bio-inert and requires supplementary modification. Plasma immersion ion implantation (PIII) has been well documented that it is a good way to improve the bioactivity of a biomaterial. It is a method that introduces new elements to the biomaterial, generating bio-functional groups on the material surface without altering its mechanical properties. Hence, the aim of this study is to improve the bioactivity of PEEK by modifying its surface chemistry with the use of water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII) without altering its mechanical properties. After PIII treatment, a series of surface characterization tests that provide information about the surface properties, such as surface energy, roughness, surface chemical composition and crystallinity of PIII-treated PEEK were carried out. Results show that both H2O PIII and NH3 PIII-treated PEEK had significantly higher surface energy and roughness than untreated PEEK. There was also no significant change in the crystallinity of the PIII-treated PEEK, indicating that PIII treatment will not alter the mechanical properties of PEEK. Improvement in wetting properties of PEEK samples suggest the formation of polar functional groups on the PIII-treated PEEK materials, while the increased in surface roughness may be due to the energetic bombardments of plasma ions on the material surface. The in vitro bioactivity of plasma-treated PEEK was investigated and confirmed with hMSC-TERT. Initial cell attachment, cell spreading area, cell proliferation and differentiation were studied. Cell adhesion and cell spreading were enhanced on PIII-treated PEEK, and higher cell viability was observed on PIII-treated PEEK. Moreover, cell proliferation was promoted on early time point and cell differentiation was also enhanced particularly on day 7 by measuring the alkaline phosphatase activity. Therefore, H2O-PIII and NH3-PIII treatments were able to promote the bioactivity of PEEK samples.
DegreeMaster of Philosophy
SubjectCrystalline polymers.
Ion implantation.
Plasma (Ionized gases)
Biomedical materials.
Orthopedic implants.
Dept/ProgramOrthopaedics and Traumatology
Persistent Identifierhttp://hdl.handle.net/10722/181882

 

DC FieldValueLanguage
dc.contributor.advisorYeung, KWK-
dc.contributor.advisorCheung, KMC-
dc.contributor.authorChong, Yu-wah.-
dc.contributor.author莊瑜華.-
dc.date.accessioned2013-03-20T06:29:48Z-
dc.date.available2013-03-20T06:29:48Z-
dc.date.issued2013-
dc.identifier.citationChong, Y. [莊瑜華]. (2013). In vitro and in vivo study of plasma immersion ion implantation (PIII) treated polyetheretherketone (PEEK). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4985883-
dc.identifier.urihttp://hdl.handle.net/10722/181882-
dc.description.abstractPolyetheretherketone (PEEK), a polymer with mechanical strength comparable to human bone, is gaining popularity in the orthopedic field because it can potentially relieve the clinical complications, such as stress shielding effect and inevitable implantation failure, which are caused by the mismatch of the mechanical strength between the current metallic implants and the implantation sites. However, it is bio-inert and requires supplementary modification. Plasma immersion ion implantation (PIII) has been well documented that it is a good way to improve the bioactivity of a biomaterial. It is a method that introduces new elements to the biomaterial, generating bio-functional groups on the material surface without altering its mechanical properties. Hence, the aim of this study is to improve the bioactivity of PEEK by modifying its surface chemistry with the use of water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII) without altering its mechanical properties. After PIII treatment, a series of surface characterization tests that provide information about the surface properties, such as surface energy, roughness, surface chemical composition and crystallinity of PIII-treated PEEK were carried out. Results show that both H2O PIII and NH3 PIII-treated PEEK had significantly higher surface energy and roughness than untreated PEEK. There was also no significant change in the crystallinity of the PIII-treated PEEK, indicating that PIII treatment will not alter the mechanical properties of PEEK. Improvement in wetting properties of PEEK samples suggest the formation of polar functional groups on the PIII-treated PEEK materials, while the increased in surface roughness may be due to the energetic bombardments of plasma ions on the material surface. The in vitro bioactivity of plasma-treated PEEK was investigated and confirmed with hMSC-TERT. Initial cell attachment, cell spreading area, cell proliferation and differentiation were studied. Cell adhesion and cell spreading were enhanced on PIII-treated PEEK, and higher cell viability was observed on PIII-treated PEEK. Moreover, cell proliferation was promoted on early time point and cell differentiation was also enhanced particularly on day 7 by measuring the alkaline phosphatase activity. Therefore, H2O-PIII and NH3-PIII treatments were able to promote the bioactivity of PEEK samples.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.source.urihttp://hub.hku.hk/bib/B4985883X-
dc.subject.lcshCrystalline polymers.-
dc.subject.lcshIon implantation.-
dc.subject.lcshPlasma (Ionized gases)-
dc.subject.lcshBiomedical materials.-
dc.subject.lcshOrthopedic implants.-
dc.titleIn vitro and in vivo study of plasma immersion ion implantation (PIII)treated polyetheretherketone (PEEK)-
dc.typePG_Thesis-
dc.identifier.hkulb4985883-
dc.description.thesisnameMaster of Philosophy-
dc.description.thesislevelMaster-
dc.description.thesisdisciplineOrthopaedics and Traumatology-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5353/th_b4985883-
dc.date.hkucongregation2013-

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