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Article: The impact of network biology in pharmacology and toxicology

TitleThe impact of network biology in pharmacology and toxicology
Authors
Issue Date2012
PublisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1062936x.asp
Citation
Sar And Qsar In Environmental Research, 2012, v. 23 n. 3-4, p. 221-235 How to Cite?
AbstractWith the need to investigate alternative approaches and emerging technologies in order to increase drug efficacy and reduce adverse drug effects, network biology offers a novel way of approaching drug discovery by considering the effect of a molecule and protein's function in a global physiological environment. By studying drug action across multiple scales of complexity, from molecular to cellular and tissue level, network-based computational methods have the potential to improve our understanding of the impact of chemicals in human health. In this review we present the available large-scale databases and tools that allow integration and analysis of such information for understanding the properties of small molecules in the context of cellular networks. With the recent advances in the omics area, global integrative approaches are necessary to cope with the massive amounts of data, and biomedical researchers are urged to implement new types of analyses that can lead to new therapeutic interventions with increased safety and efficacy compared with existing medications. © 2012 Copyright Taylor and Francis Group, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/181265
ISSN
2015 Impact Factor: 1.897
2015 SCImago Journal Rankings: 0.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPanagiotou, Gen_US
dc.contributor.authorTaboureau, Oen_US
dc.date.accessioned2013-02-21T02:03:36Z-
dc.date.available2013-02-21T02:03:36Z-
dc.date.issued2012en_US
dc.identifier.citationSar And Qsar In Environmental Research, 2012, v. 23 n. 3-4, p. 221-235en_US
dc.identifier.issn1062-936Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/181265-
dc.description.abstractWith the need to investigate alternative approaches and emerging technologies in order to increase drug efficacy and reduce adverse drug effects, network biology offers a novel way of approaching drug discovery by considering the effect of a molecule and protein's function in a global physiological environment. By studying drug action across multiple scales of complexity, from molecular to cellular and tissue level, network-based computational methods have the potential to improve our understanding of the impact of chemicals in human health. In this review we present the available large-scale databases and tools that allow integration and analysis of such information for understanding the properties of small molecules in the context of cellular networks. With the recent advances in the omics area, global integrative approaches are necessary to cope with the massive amounts of data, and biomedical researchers are urged to implement new types of analyses that can lead to new therapeutic interventions with increased safety and efficacy compared with existing medications. © 2012 Copyright Taylor and Francis Group, LLC.en_US
dc.languageengen_US
dc.publisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1062936x.aspen_US
dc.relation.ispartofSAR and QSAR in Environmental Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrug Discovery - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshPharmacologyen_US
dc.subject.meshProteins - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRisk Assessment - Methodsen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshSystems Biologyen_US
dc.subject.meshToxicologyen_US
dc.titleThe impact of network biology in pharmacology and toxicologyen_US
dc.typeArticleen_US
dc.identifier.emailPanagiotou, G: gipa@hku.hken_US
dc.identifier.authorityPanagiotou, G=rp01725en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/1062936X.2012.657237en_US
dc.identifier.pmid22352466-
dc.identifier.scopuseid_2-s2.0-84860296344en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860296344&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue3-4en_US
dc.identifier.spage221en_US
dc.identifier.epage235en_US
dc.identifier.isiWOS:000303126400002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPanagiotou, G=8566179700en_US
dc.identifier.scopusauthoridTaboureau, O=8857290100en_US

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