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Article: Nutritional systems biology: Definitions and approaches

TitleNutritional systems biology: Definitions and approaches
Authors
Issue Date2009
PublisherAnnual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/nutr
Citation
Annual Review Of Nutrition, 2009, v. 29, p. 329-339 How to Cite?
AbstractNutrigenetics and nutrigenomics are nascent areas that are evolving quickly and riding on the wave of "personalized medicine" that is providing opportunities in the discovery and development of nutraceutical compounds. The human genome sequence and sequences of model organisms provide the equivalent of comprehensive blueprints and parts lists that describe dynamic networks and the bases for understanding their responses to external and internal perturbations. Unfolding the interrelationships among genes, gene products, and dietary habits is fundamental for identifying individuals who will benefit most from, or be placed at risk by, intervention strategies. More accurate assessment of the inputs to human health and the consequences of those inputs measured as accurate transcriptomic, proteomic, and metabolomic analyses would bring personalized health/diet to practice far faster than would waiting for a predictive knowledge of genetic variation. It is widely recognized that systems and network biology has the potential to increase our understanding of how nutrition influences metabolic pathways and homeostasis, how this regulation is disturbed in a diet-related disease, and to what extent individual genotypes contribute to such diseases. Copyright © 2009 by Annual Reviews. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/181255
ISSN
2015 Impact Factor: 6.784
2015 SCImago Journal Rankings: 5.192
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPanagiotou, Gen_US
dc.contributor.authorNielsen, Jen_US
dc.date.accessioned2013-02-21T02:03:32Z-
dc.date.available2013-02-21T02:03:32Z-
dc.date.issued2009en_US
dc.identifier.citationAnnual Review Of Nutrition, 2009, v. 29, p. 329-339en_US
dc.identifier.issn0199-9885en_US
dc.identifier.urihttp://hdl.handle.net/10722/181255-
dc.description.abstractNutrigenetics and nutrigenomics are nascent areas that are evolving quickly and riding on the wave of "personalized medicine" that is providing opportunities in the discovery and development of nutraceutical compounds. The human genome sequence and sequences of model organisms provide the equivalent of comprehensive blueprints and parts lists that describe dynamic networks and the bases for understanding their responses to external and internal perturbations. Unfolding the interrelationships among genes, gene products, and dietary habits is fundamental for identifying individuals who will benefit most from, or be placed at risk by, intervention strategies. More accurate assessment of the inputs to human health and the consequences of those inputs measured as accurate transcriptomic, proteomic, and metabolomic analyses would bring personalized health/diet to practice far faster than would waiting for a predictive knowledge of genetic variation. It is widely recognized that systems and network biology has the potential to increase our understanding of how nutrition influences metabolic pathways and homeostasis, how this regulation is disturbed in a diet-related disease, and to what extent individual genotypes contribute to such diseases. Copyright © 2009 by Annual Reviews. All rights reserved.en_US
dc.languageengen_US
dc.publisherAnnual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/nutren_US
dc.relation.ispartofAnnual Review of Nutritionen_US
dc.subject.meshHuman Genome Projecten_US
dc.subject.meshHumansen_US
dc.subject.meshNutrigenomics - Trendsen_US
dc.subject.meshNutrition Therapy - Methods - Trendsen_US
dc.subject.meshNutritional Physiological Phenomena - Geneticsen_US
dc.subject.meshPharmacogeneticsen_US
dc.titleNutritional systems biology: Definitions and approachesen_US
dc.typeArticleen_US
dc.identifier.emailPanagiotou, G: gipa@hku.hken_US
dc.identifier.authorityPanagiotou, G=rp01725en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1146/annurev-nutr-080508-141138en_US
dc.identifier.pmid19575602-
dc.identifier.scopuseid_2-s2.0-67749111667en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67749111667&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.spage329en_US
dc.identifier.epage339en_US
dc.identifier.isiWOS:000270118600014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPanagiotou, G=8566179700en_US
dc.identifier.scopusauthoridNielsen, J=7404066338en_US

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