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Article: Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions

TitlePhysiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/71002188
Citation
Biotechnology And Bioengineering, 2007, v. 98 n. 2, p. 462-475 How to Cite?
AbstractThe physiology of Aspergillus niger was studied under different aeration conditions. Five different aeration rates were investigated in batch cultivations of A. niger grown on xylose. Biomass, intra- and extra-cellular metabolites profiles were determined and ten different enzyme activities in the central carbon metabolism were assessed. The focus was on organic acid production with a special interest in succinate production. The fermentations revealed that oxygen limitation significantly changes the physiology of the micro-organism. Changes in extra cellular metabolite profiles were observed, that is, there was a drastic increase in polyol production (erythritol, xylitol, glycerol, arabitol, and mannitol) and to a lesser extent in the production of reduced acids (malate and succinate). The intracellular metabolite profiles indicated changes in fluxes, since several primary metabolites, like the intermediates of the TCA cycle accumulated during oxygen limitation (on average three fold increase). Also the enzyme activities showed changes between the exponential growth phase and the oxygen limitation phase. In general, the oxygen availability has a significant impact on the physiology of this fungus causing dramatic alterations in the central carbon metabolism that should be taken into account in the design of A. niger as a succinate cell factory. © 2007 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/181246
ISSN
2015 Impact Factor: 4.243
2015 SCImago Journal Rankings: 1.633
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMeijer, Sen_US
dc.contributor.authorPanagiotou, Gen_US
dc.contributor.authorOlsson, Len_US
dc.contributor.authorNielsen, Jen_US
dc.date.accessioned2013-02-21T02:03:28Z-
dc.date.available2013-02-21T02:03:28Z-
dc.date.issued2007en_US
dc.identifier.citationBiotechnology And Bioengineering, 2007, v. 98 n. 2, p. 462-475en_US
dc.identifier.issn0006-3592en_US
dc.identifier.urihttp://hdl.handle.net/10722/181246-
dc.description.abstractThe physiology of Aspergillus niger was studied under different aeration conditions. Five different aeration rates were investigated in batch cultivations of A. niger grown on xylose. Biomass, intra- and extra-cellular metabolites profiles were determined and ten different enzyme activities in the central carbon metabolism were assessed. The focus was on organic acid production with a special interest in succinate production. The fermentations revealed that oxygen limitation significantly changes the physiology of the micro-organism. Changes in extra cellular metabolite profiles were observed, that is, there was a drastic increase in polyol production (erythritol, xylitol, glycerol, arabitol, and mannitol) and to a lesser extent in the production of reduced acids (malate and succinate). The intracellular metabolite profiles indicated changes in fluxes, since several primary metabolites, like the intermediates of the TCA cycle accumulated during oxygen limitation (on average three fold increase). Also the enzyme activities showed changes between the exponential growth phase and the oxygen limitation phase. In general, the oxygen availability has a significant impact on the physiology of this fungus causing dramatic alterations in the central carbon metabolism that should be taken into account in the design of A. niger as a succinate cell factory. © 2007 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/71002188en_US
dc.relation.ispartofBiotechnology and Bioengineeringen_US
dc.subject.meshAerobiosis - Physiologyen_US
dc.subject.meshAnaerobiosis - Physiologyen_US
dc.subject.meshAspergillus Niger - Metabolismen_US
dc.subject.meshBioreactors - Microbiologyen_US
dc.subject.meshCitric Acid Cycle - Physiologyen_US
dc.subject.meshMetabolism - Physiologyen_US
dc.subject.meshSuccinic Acid - Metabolismen_US
dc.subject.meshXylose - Metabolismen_US
dc.titlePhysiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditionsen_US
dc.typeArticleen_US
dc.identifier.emailPanagiotou, G: gipa@hku.hken_US
dc.identifier.authorityPanagiotou, G=rp01725en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/bit.21397en_US
dc.identifier.pmid17335061-
dc.identifier.scopuseid_2-s2.0-34948844168en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34948844168&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue2en_US
dc.identifier.spage462en_US
dc.identifier.epage475en_US
dc.identifier.isiWOS:000249408400015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMeijer, S=22234607600en_US
dc.identifier.scopusauthoridPanagiotou, G=8566179700en_US
dc.identifier.scopusauthoridOlsson, L=7203077540en_US
dc.identifier.scopusauthoridNielsen, J=7404066338en_US

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