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Article: Potential effect of inter-genic action on peak bone mass (PBM) in Chinese females

TitlePotential effect of inter-genic action on peak bone mass (PBM) in Chinese females
Authors
Issue Date2005
Citation
Acta Genetica Sinica, 2005, v. 32 n. 10, p. 1003-1010 How to Cite?
AbstractPeak bone mass (PBM) is a complex trait, determined by both genetic and environmental factors and also their interactions. Vitamin D receptor (VDR), estrogen receptor α (ERα), interleukin 6 (IL6), parathyroid hormone (PTH), collagen type I alpha 2 (COL1A2), bone Gla protein (BGP), alpha2-HS glycoprotein (AHSG) are among the important candidate genes of bone metabolism. The study aims to detect significant effect of potential inter-genic action underlying PBM in Chinese females. 361 unrelated healthy premenopausal Chinese females (aged 20-44 years) with Han ethnicity were recruited from the Shanghai city in China. Bone mineral density (BMD) at the hip and the lumbar spine (L1-4) was measured using a Hologic QDR 2000 + dual-energy X-ray absorptiometry (DXA) scanner. Eight polymorphisms among the seven genes were genotyped, i. e. Apa I in VDR, Pvu II and Xba I in ERα (ERX and ERP, respectively), BsrB I in IL6, BstB I in PTH, Msp I in COL1A2, Hind III in BGP, and Sac I in AHSG, using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) methods. Two-way analysis of variance (ANOVA) showed significant effects of IL6 x ERP interaction on PBM at the total hip (P = 0.019), intertrochanter (P = 0.016), and femoral neck (P = 0.019). The BMD difference between GGPp carriers and GGpp subjects (at these two loci) amounted to 18.0%, 19.5%, and 14.8% at the hip, intertrochanter,and femoral neck, respectively. The potential interaction effect of AHSG x IL6 was observed on femoral neck PBM (P = 0.046). GGSS individuals (at these two loci) had, on average, 18.8% higher femoral neck BMD than those subjects with GGSs genotype. The population-level statistical analysis indicates that IL6 x ERP and AHSG x IL6 have significant inter-genic effect on the genetic determination of PBM in Chinese females.
Persistent Identifierhttp://hdl.handle.net/10722/181206
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorDeng, FYen_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorLei, SFen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:48Z-
dc.date.available2013-02-21T02:02:48Z-
dc.date.issued2005en_US
dc.identifier.citationActa Genetica Sinica, 2005, v. 32 n. 10, p. 1003-1010en_US
dc.identifier.issn0379-4172en_US
dc.identifier.urihttp://hdl.handle.net/10722/181206-
dc.description.abstractPeak bone mass (PBM) is a complex trait, determined by both genetic and environmental factors and also their interactions. Vitamin D receptor (VDR), estrogen receptor α (ERα), interleukin 6 (IL6), parathyroid hormone (PTH), collagen type I alpha 2 (COL1A2), bone Gla protein (BGP), alpha2-HS glycoprotein (AHSG) are among the important candidate genes of bone metabolism. The study aims to detect significant effect of potential inter-genic action underlying PBM in Chinese females. 361 unrelated healthy premenopausal Chinese females (aged 20-44 years) with Han ethnicity were recruited from the Shanghai city in China. Bone mineral density (BMD) at the hip and the lumbar spine (L1-4) was measured using a Hologic QDR 2000 + dual-energy X-ray absorptiometry (DXA) scanner. Eight polymorphisms among the seven genes were genotyped, i. e. Apa I in VDR, Pvu II and Xba I in ERα (ERX and ERP, respectively), BsrB I in IL6, BstB I in PTH, Msp I in COL1A2, Hind III in BGP, and Sac I in AHSG, using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) methods. Two-way analysis of variance (ANOVA) showed significant effects of IL6 x ERP interaction on PBM at the total hip (P = 0.019), intertrochanter (P = 0.016), and femoral neck (P = 0.019). The BMD difference between GGPp carriers and GGpp subjects (at these two loci) amounted to 18.0%, 19.5%, and 14.8% at the hip, intertrochanter,and femoral neck, respectively. The potential interaction effect of AHSG x IL6 was observed on femoral neck PBM (P = 0.046). GGSS individuals (at these two loci) had, on average, 18.8% higher femoral neck BMD than those subjects with GGSs genotype. The population-level statistical analysis indicates that IL6 x ERP and AHSG x IL6 have significant inter-genic effect on the genetic determination of PBM in Chinese females.en_US
dc.languageengen_US
dc.relation.ispartofActa Genetica Sinicaen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAdulten_US
dc.subject.meshAllelesen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBlood Proteins - Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshCollagen - Geneticsen_US
dc.subject.meshCollagen Type Ien_US
dc.subject.meshEstrogen Receptor Alpha - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemur - Metabolism - Radiographyen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-6 - Geneticsen_US
dc.subject.meshLumbar Vertebrae - Metabolism - Radiographyen_US
dc.subject.meshOsteocalcin - Geneticsen_US
dc.subject.meshParathyroid Hormone - Geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshReceptors, Calcitriol - Geneticsen_US
dc.subject.meshYoung Adulten_US
dc.subject.meshAlpha-2-Hs-Glycoproteinen_US
dc.titlePotential effect of inter-genic action on peak bone mass (PBM) in Chinese femalesen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16252694-
dc.identifier.scopuseid_2-s2.0-26944470371en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26944470371&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue10en_US
dc.identifier.spage1003en_US
dc.identifier.epage1010en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridDeng, FY=19640145800en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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