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Article: Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women

TitleLack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women
Authors
Issue Date2004
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm
Citation
Journal Of Bone And Mineral Metabolism, 2004, v. 22 n. 3, p. 264-269 How to Cite?
AbstractIn Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindIII polymorphism and bone mineral density (BMD) in 388 premenopausal (31.18 ± 5.92 years) and 169 postmenopausal (58.90 ± 6.27 years) Chinese women. The BMD of spine and hip was measured by dual-energy X-ray absorptiometry (DEXA). All the study subjects were genotyped at the HindIII site of the BGP gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) detecting methods. The BGP alleles were designated according to the absence (H) or presence (h) of the HindIII restriction site. We did not find any significant difference in spine and hip BMD across BGP genotypes in either pre- or postmenopausal women or the combined group. Our result is not consistent with recent reports that the HindIII marker of the BGP gene is associated with osteoporosis. The different findings may reflect inter-population differences in the association (i.e., linkage disequilibrium) of molecular markers with BMD, and indicate the limit of using the HindIII marker of the BGP gene as a genetic marker to discern women susceptible to low BMD and thus osteoporosis in Chinese.
Persistent Identifierhttp://hdl.handle.net/10722/181204
ISSN
2015 Impact Factor: 2.312
2015 SCImago Journal Rankings: 0.775
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMo, XYen_US
dc.contributor.authorCao, CKen_US
dc.contributor.authorXu, FHen_US
dc.contributor.authorLiu, MYen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorQin, YJen_US
dc.contributor.authorZhou, Qen_US
dc.contributor.authorZhang, YYen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:47Z-
dc.date.available2013-02-21T02:02:47Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Bone And Mineral Metabolism, 2004, v. 22 n. 3, p. 264-269en_US
dc.identifier.issn0914-8779en_US
dc.identifier.urihttp://hdl.handle.net/10722/181204-
dc.description.abstractIn Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindIII polymorphism and bone mineral density (BMD) in 388 premenopausal (31.18 ± 5.92 years) and 169 postmenopausal (58.90 ± 6.27 years) Chinese women. The BMD of spine and hip was measured by dual-energy X-ray absorptiometry (DEXA). All the study subjects were genotyped at the HindIII site of the BGP gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) detecting methods. The BGP alleles were designated according to the absence (H) or presence (h) of the HindIII restriction site. We did not find any significant difference in spine and hip BMD across BGP genotypes in either pre- or postmenopausal women or the combined group. Our result is not consistent with recent reports that the HindIII marker of the BGP gene is associated with osteoporosis. The different findings may reflect inter-population differences in the association (i.e., linkage disequilibrium) of molecular markers with BMD, and indicate the limit of using the HindIII marker of the BGP gene as a genetic marker to discern women susceptible to low BMD and thus osteoporosis in Chinese.en_US
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htmen_US
dc.relation.ispartofJournal of Bone and Mineral Metabolismen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBone Density - Genetics - Physiologyen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHealthen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteocalcin - Geneticsen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshPostmenopause - Genetics - Physiologyen_US
dc.subject.meshPremenopause - Genetics - Physiologyen_US
dc.subject.meshSite-Specific Dna-Methyltransferase (Adenine-Specific) - Metabolismen_US
dc.titleLack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00774-003-0478-7en_US
dc.identifier.pmid15108070-
dc.identifier.scopuseid_2-s2.0-2442651258en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442651258&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue3en_US
dc.identifier.spage264en_US
dc.identifier.epage269en_US
dc.identifier.isiWOS:000221055600015-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridMo, XY=7102096615en_US
dc.identifier.scopusauthoridCao, CK=7401501850en_US
dc.identifier.scopusauthoridXu, FH=7401695313en_US
dc.identifier.scopusauthoridLiu, MY=37065486200en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridQin, YJ=7403100918en_US
dc.identifier.scopusauthoridZhou, Q=7402700311en_US
dc.identifier.scopusauthoridZhang, YY=12781205700en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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