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Article: Linkage exclusion analysis of two important chromosomal regions for height

TitleLinkage exclusion analysis of two important chromosomal regions for height
Authors
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2005, v. 335 n. 4, p. 1287-1292 How to Cite?
AbstractAdult height (stature), as an important parameter of human physical development, has been studied in many populations. Recently, we reported a whole genome scan of height on a sample of 630 Caucasian subjects from 53 human pedigrees. Two chromosome regions, 6q24-25 and 7q31.3-36, achieved low linkage signals (multipoint LOD score ≤0.5), but gained significant results in the linkage studies of height by other groups. In addition, the region 6q24-25 harbors the ER-α gene, an important candidate gene for linear growth. To resolve the controversies over these two regions for height, linkage exclusion analyses were performed in an extended sample of 79 pedigrees with 1816 subjects, which include the 53 pedigrees containing 630 subjects for our previous whole genome study and additional 128 new subjects, and 26 new pedigrees containing 1058 subjects. The two regions, 6q24-25 and 7q31.3-36, were excluded at a relative effect size of 10% or greater (p value < 0.0005) and 5% or greater (p value < 0.0018), respectively. Our results suggest that the two regions may not contribute substantially to height variation in our Caucasian population. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/181202
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, YJen_US
dc.contributor.authorLiu, YZen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorLei, SFen_US
dc.contributor.authorChen, XDen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:46Z-
dc.date.available2013-02-21T02:02:46Z-
dc.date.issued2005en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2005, v. 335 n. 4, p. 1287-1292en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/181202-
dc.description.abstractAdult height (stature), as an important parameter of human physical development, has been studied in many populations. Recently, we reported a whole genome scan of height on a sample of 630 Caucasian subjects from 53 human pedigrees. Two chromosome regions, 6q24-25 and 7q31.3-36, achieved low linkage signals (multipoint LOD score ≤0.5), but gained significant results in the linkage studies of height by other groups. In addition, the region 6q24-25 harbors the ER-α gene, an important candidate gene for linear growth. To resolve the controversies over these two regions for height, linkage exclusion analyses were performed in an extended sample of 79 pedigrees with 1816 subjects, which include the 53 pedigrees containing 630 subjects for our previous whole genome study and additional 128 new subjects, and 26 new pedigrees containing 1058 subjects. The two regions, 6q24-25 and 7q31.3-36, were excluded at a relative effect size of 10% or greater (p value < 0.0005) and 5% or greater (p value < 0.0018), respectively. Our results suggest that the two regions may not contribute substantially to height variation in our Caucasian population. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBody Height - Geneticsen_US
dc.subject.meshChromosome Mapping - Methodsen_US
dc.subject.meshChromosomes, Humanen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Linkage - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshQuantitative Trait Loci - Geneticsen_US
dc.subject.meshUnited States - Epidemiologyen_US
dc.titleLinkage exclusion analysis of two important chromosomal regions for heighten_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2005.08.027en_US
dc.identifier.pmid16112080-
dc.identifier.scopuseid_2-s2.0-24044529176en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24044529176&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume335en_US
dc.identifier.issue4en_US
dc.identifier.spage1287en_US
dc.identifier.epage1292en_US
dc.identifier.isiWOS:000231817600040-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYang, YJ=23500643600en_US
dc.identifier.scopusauthoridLiu, YZ=7410227746en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridChen, XD=35487111000en_US
dc.identifier.scopusauthoridSun, X=36811239200en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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