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Article: Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese

TitleAssociation and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese
Authors
Issue Date2005
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm
Citation
Journal Of Bone And Mineral Metabolism, 2005, v. 23 n. 4, p. 323-328 How to Cite?
AbstractIn this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RFLP) site (ID, RS1800796) in 1263 individuals from 402 Chinese nuclear families, composed of both parents and at least one healthy daughter (mean age ± SD, 31.4 ± 5.8 years). Using the daughters' bone phenotypes, we tested total-family association, within-family association (via transmission disequilibrium test, [TDT]), and linkage, between the -634C/G marker and bone phenotypes at the spine and the hip. No significant association or linkage was found for bone size and BMD, although a trend was observed for linkage between the IL-6 gene -634C/G marker and L1-4 spinal BMD (adjusted for age, weight, and height). Our results, together with the findings from other studies, indicate that the IL-6 gene, although important for postmenopausal bone loss, may have a limited impact on peak bone mass variation in a Chinese population. © Springer-Verlag 2005.
Persistent Identifierhttp://hdl.handle.net/10722/181198
ISSN
2015 Impact Factor: 2.312
2015 SCImago Journal Rankings: 0.775
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLei, SFen_US
dc.contributor.authorLiu, YZen_US
dc.contributor.authorDeng, FYen_US
dc.contributor.authorLi, YMen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:43Z-
dc.date.available2013-02-21T02:02:43Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Bone And Mineral Metabolism, 2005, v. 23 n. 4, p. 323-328en_US
dc.identifier.issn0914-8779en_US
dc.identifier.urihttp://hdl.handle.net/10722/181198-
dc.description.abstractIn this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RFLP) site (ID, RS1800796) in 1263 individuals from 402 Chinese nuclear families, composed of both parents and at least one healthy daughter (mean age ± SD, 31.4 ± 5.8 years). Using the daughters' bone phenotypes, we tested total-family association, within-family association (via transmission disequilibrium test, [TDT]), and linkage, between the -634C/G marker and bone phenotypes at the spine and the hip. No significant association or linkage was found for bone size and BMD, although a trend was observed for linkage between the IL-6 gene -634C/G marker and L1-4 spinal BMD (adjusted for age, weight, and height). Our results, together with the findings from other studies, indicate that the IL-6 gene, although important for postmenopausal bone loss, may have a limited impact on peak bone mass variation in a Chinese population. © Springer-Verlag 2005.en_US
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htmen_US
dc.relation.ispartofJournal of Bone and Mineral Metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBone Density - Genetics - Immunologyen_US
dc.subject.meshBone And Bones - Anatomy & Histologyen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-6 - Geneticsen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleAssociation and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00774-004-0607-yen_US
dc.identifier.pmid15981030-
dc.identifier.scopuseid_2-s2.0-21044450680en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21044450680&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue4en_US
dc.identifier.spage323en_US
dc.identifier.epage328en_US
dc.identifier.isiWOS:000230069500009-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridLiu, YZ=7410227746en_US
dc.identifier.scopusauthoridDeng, FY=19640145800en_US
dc.identifier.scopusauthoridLi, YM=7502098054en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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