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- Publisher Website: 10.1016/j.bone.2005.01.013
- Scopus: eid_2-s2.0-20944437651
- PMID: 15780973
- WOS: WOS:000228986600013
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Article: No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women
Title | No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women |
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Authors | |
Keywords | Association Bone mineral density IGF-I gene Linkage Osteoporosis |
Issue Date | 2005 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone |
Citation | Bone, 2005, v. 36 n. 4, p. 694-699 How to Cite? |
Abstract | Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm2) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women. © 2005 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/181197 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.179 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jiang, DK | en_US |
dc.contributor.author | Shen, H | en_US |
dc.contributor.author | Li, MX | en_US |
dc.contributor.author | Jiang, C | en_US |
dc.contributor.author | Yang, N | en_US |
dc.contributor.author | Zhu, J | en_US |
dc.contributor.author | Wu, Y | en_US |
dc.contributor.author | Qin, YJ | en_US |
dc.contributor.author | Zhou, Q | en_US |
dc.contributor.author | Deng, HW | en_US |
dc.date.accessioned | 2013-02-21T02:02:43Z | - |
dc.date.available | 2013-02-21T02:02:43Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Bone, 2005, v. 36 n. 4, p. 694-699 | en_US |
dc.identifier.issn | 8756-3282 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/181197 | - |
dc.description.abstract | Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm2) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women. © 2005 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone | en_US |
dc.relation.ispartof | Bone | en_US |
dc.subject | Association | - |
dc.subject | Bone mineral density | - |
dc.subject | IGF-I gene | - |
dc.subject | Linkage | - |
dc.subject | Osteoporosis | - |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | Bone Density - Genetics | en_US |
dc.subject.mesh | China | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Insulin-Like Growth Factor I - Genetics | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Premenopause | en_US |
dc.title | No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, MX: mxli@hku.hk | en_US |
dc.identifier.authority | Li, MX=rp01722 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.bone.2005.01.013 | en_US |
dc.identifier.pmid | 15780973 | - |
dc.identifier.scopus | eid_2-s2.0-20944437651 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-20944437651&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 694 | en_US |
dc.identifier.epage | 699 | en_US |
dc.identifier.isi | WOS:000228986600013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Jiang, DK=55344961200 | en_US |
dc.identifier.scopusauthorid | Shen, H=36126870600 | en_US |
dc.identifier.scopusauthorid | Li, MX=17135391100 | en_US |
dc.identifier.scopusauthorid | Jiang, C=36484765000 | en_US |
dc.identifier.scopusauthorid | Yang, N=35188348600 | en_US |
dc.identifier.scopusauthorid | Zhu, J=16445001900 | en_US |
dc.identifier.scopusauthorid | Wu, Y=16950013200 | en_US |
dc.identifier.scopusauthorid | Qin, YJ=7403100918 | en_US |
dc.identifier.scopusauthorid | Zhou, Q=7402700311 | en_US |
dc.identifier.scopusauthorid | Deng, HW=34568563000 | en_US |
dc.identifier.issnl | 1873-2763 | - |