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Article: No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women

TitleNo major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone
Citation
Bone, 2005, v. 36 n. 4, p. 694-699 How to Cite?
AbstractOsteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm2) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/181197
ISSN
2015 Impact Factor: 3.736
2015 SCImago Journal Rankings: 1.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, DKen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorJiang, Cen_US
dc.contributor.authorYang, Nen_US
dc.contributor.authorZhu, Jen_US
dc.contributor.authorWu, Yen_US
dc.contributor.authorQin, YJen_US
dc.contributor.authorZhou, Qen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:43Z-
dc.date.available2013-02-21T02:02:43Z-
dc.date.issued2005en_US
dc.identifier.citationBone, 2005, v. 36 n. 4, p. 694-699en_US
dc.identifier.issn8756-3282en_US
dc.identifier.urihttp://hdl.handle.net/10722/181197-
dc.description.abstractOsteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm2) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/boneen_US
dc.relation.ispartofBoneen_US
dc.subject.meshAllelesen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Like Growth Factor I - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPremenopauseen_US
dc.titleNo major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bone.2005.01.013en_US
dc.identifier.pmid15780973-
dc.identifier.scopuseid_2-s2.0-20944437651en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20944437651&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue4en_US
dc.identifier.spage694en_US
dc.identifier.epage699en_US
dc.identifier.isiWOS:000228986600013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJiang, DK=55344961200en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridJiang, C=36484765000en_US
dc.identifier.scopusauthoridYang, N=35188348600en_US
dc.identifier.scopusauthoridZhu, J=16445001900en_US
dc.identifier.scopusauthoridWu, Y=16950013200en_US
dc.identifier.scopusauthoridQin, YJ=7403100918en_US
dc.identifier.scopusauthoridZhou, Q=7402700311en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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