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Article: A major gene model of adult height is suggested in Chinese

TitleA major gene model of adult height is suggested in Chinese
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html
Citation
Journal Of Human Genetics, 2004, v. 49 n. 3, p. 148-153 How to Cite?
AbstractAdult height (stature), as a complex quantitative trait, has been studied in different populations. However, few genetic studies on height were performed on the Chinese, the largest population in the world. In this study, familial correlation and segregation analyses were carried out for adult height in a Chinese sample composed of 385 nuclear families with a total of 1,169 informative individuals. The results suggest that a major gene with a recessive effect accounts for about 17.2% of the total adult height variation in the Chinese. Significant familial residual effects are found. The heritability (±SE) of height is estimated to be 0.647 (±0.122). This study, for the first time, provides evidence for the high degree of genetic determination of adult height in the Chinese population and furnishes a valuable reference for further mapping and identification of adult height genes in the Chinese.
Persistent Identifierhttp://hdl.handle.net/10722/181196
ISSN
2015 Impact Factor: 2.487
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, MXen_US
dc.contributor.authorLiu, PYen_US
dc.contributor.authorLi, YMen_US
dc.contributor.authorQin, YJen_US
dc.contributor.authorLiu, YZen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:42Z-
dc.date.available2013-02-21T02:02:42Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Human Genetics, 2004, v. 49 n. 3, p. 148-153en_US
dc.identifier.issn1434-5161en_US
dc.identifier.urihttp://hdl.handle.net/10722/181196-
dc.description.abstractAdult height (stature), as a complex quantitative trait, has been studied in different populations. However, few genetic studies on height were performed on the Chinese, the largest population in the world. In this study, familial correlation and segregation analyses were carried out for adult height in a Chinese sample composed of 385 nuclear families with a total of 1,169 informative individuals. The results suggest that a major gene with a recessive effect accounts for about 17.2% of the total adult height variation in the Chinese. Significant familial residual effects are found. The heritability (±SE) of height is estimated to be 0.647 (±0.122). This study, for the first time, provides evidence for the high degree of genetic determination of adult height in the Chinese population and furnishes a valuable reference for further mapping and identification of adult height genes in the Chinese.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.htmlen_US
dc.relation.ispartofJournal of Human Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBody Height - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshFamily Healthen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshModels, Statisticalen_US
dc.subject.meshNuclear Familyen_US
dc.subject.meshSoftwareen_US
dc.titleA major gene model of adult height is suggested in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10038-004-0125-8en_US
dc.identifier.pmid14991526-
dc.identifier.scopuseid_2-s2.0-1942488384en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1942488384&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue3en_US
dc.identifier.spage148en_US
dc.identifier.epage153en_US
dc.identifier.isiWOS:000220459100006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US
dc.identifier.scopusauthoridLi, YM=7502098054en_US
dc.identifier.scopusauthoridQin, YJ=7403100918en_US
dc.identifier.scopusauthoridLiu, YZ=7410227746en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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