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Article: Robust indices of Hardy-Weinberg disequilibrium for QTL fine mapping

TitleRobust indices of Hardy-Weinberg disequilibrium for QTL fine mapping
Authors
Issue Date2003
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation
Human Heredity, 2003, v. 56 n. 4, p. 160-165 How to Cite?
AbstractHardy-Weinberg disequilibrium (HWD) measures have been proposed using dense markers to fine map a quantitative trait locus (QTL) to regions < ∼ 1 cM. Earlier HWD measures may introduce bias in the fine mapping because they are dependent on marker allele frequencies across loci. Hence, HWD indices that do not depend on marker allele frequencies are desired for fine mapping. Based on our earlier work, here we present four new HWD indices that do not depend on marker allele frequencies. Two are for use when marker allele frequencies in a study population are known, and two are for use when marker allele frequencies in a study population are not known and are only known in the extreme samples. The new measures are a function of the genetic distance between the marker locus and a QTL. Through simulations, we investigated and compared the fine mapping performance of the new HWD measures with that of the earlier ones. Our results show that when marker allele frequencies vary across loci, the new measures presented here are more robust and powerful. Copyright © 2003 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/181192
ISSN
2015 Impact Factor: 1.539
2015 SCImago Journal Rankings: 0.942
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDeng, HWen_US
dc.contributor.authorLi, YMen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorLiu, PYen_US
dc.date.accessioned2013-02-21T02:02:39Z-
dc.date.available2013-02-21T02:02:39Z-
dc.date.issued2003en_US
dc.identifier.citationHuman Heredity, 2003, v. 56 n. 4, p. 160-165en_US
dc.identifier.issn0001-5652en_US
dc.identifier.urihttp://hdl.handle.net/10722/181192-
dc.description.abstractHardy-Weinberg disequilibrium (HWD) measures have been proposed using dense markers to fine map a quantitative trait locus (QTL) to regions < ∼ 1 cM. Earlier HWD measures may introduce bias in the fine mapping because they are dependent on marker allele frequencies across loci. Hence, HWD indices that do not depend on marker allele frequencies are desired for fine mapping. Based on our earlier work, here we present four new HWD indices that do not depend on marker allele frequencies. Two are for use when marker allele frequencies in a study population are known, and two are for use when marker allele frequencies in a study population are not known and are only known in the extreme samples. The new measures are a function of the genetic distance between the marker locus and a QTL. Through simulations, we investigated and compared the fine mapping performance of the new HWD measures with that of the earlier ones. Our results show that when marker allele frequencies vary across loci, the new measures presented here are more robust and powerful. Copyright © 2003 S. Karger AG, Basel.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHEen_US
dc.relation.ispartofHuman Heredityen_US
dc.subject.meshChromosome Mapping - Methodsen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshQuantitative Trait Locien_US
dc.titleRobust indices of Hardy-Weinberg disequilibrium for QTL fine mappingen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000076391en_US
dc.identifier.pmid15031618-
dc.identifier.scopuseid_2-s2.0-1642635110en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642635110&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue4en_US
dc.identifier.spage160en_US
dc.identifier.epage165en_US
dc.identifier.isiWOS:000220301700002-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US
dc.identifier.scopusauthoridLi, YM=7502098054en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US

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