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Article: Parathyroid hormone gene with bone phenotypes in Chinese

TitleParathyroid hormone gene with bone phenotypes in Chinese
Authors
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2003, v. 307 n. 3, p. 666-671 How to Cite?
AbstractOsteoporosis is a common disorder afflicting old people. The parathyroid hormone (PTH) gene is involved in bone remodeling and calcium homeostasis, and has been considered as an important candidate gene for osteoporosis. In this study, we simultaneously tested linkage and/or association of PTH gene with bone mineral density (BMD) and bone mineral content (BMC), two important risk factors for osteoporosis. A sample of 1263 subjects from 402 Chinese nuclear families was used. The families are composed of both parents and at least one healthy daughter aged from 20 to 45 years. All the subjects were genotyped at the polymorphic BstBI site inside the intron 2 of the PTH gene (a nucleotide substitution of G to A at the position +3244). BMD and BMC were measured at the lumbar spine and the hip region via dual-energy X-ray absorptiometry (DXA). Using QTDT (quantitative trait transmission disequilibrium test), we did not find significant results for association or linkage between the PTH gene and BMD or BMC variation at the spine or hip. Our data do not support the PTH gene as a quantitative trait locus (QTL) underlying the bone phenotypic variation in the Chinese population. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/181187
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, XGen_US
dc.contributor.authorLiu, YZen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorJian, WXen_US
dc.contributor.authorLei, SFen_US
dc.contributor.authorQin, YJen_US
dc.contributor.authorZhou, Qen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:36Z-
dc.date.available2013-02-21T02:02:36Z-
dc.date.issued2003en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2003, v. 307 n. 3, p. 666-671en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/181187-
dc.description.abstractOsteoporosis is a common disorder afflicting old people. The parathyroid hormone (PTH) gene is involved in bone remodeling and calcium homeostasis, and has been considered as an important candidate gene for osteoporosis. In this study, we simultaneously tested linkage and/or association of PTH gene with bone mineral density (BMD) and bone mineral content (BMC), two important risk factors for osteoporosis. A sample of 1263 subjects from 402 Chinese nuclear families was used. The families are composed of both parents and at least one healthy daughter aged from 20 to 45 years. All the subjects were genotyped at the polymorphic BstBI site inside the intron 2 of the PTH gene (a nucleotide substitution of G to A at the position +3244). BMD and BMC were measured at the lumbar spine and the hip region via dual-energy X-ray absorptiometry (DXA). Using QTDT (quantitative trait transmission disequilibrium test), we did not find significant results for association or linkage between the PTH gene and BMD or BMC variation at the spine or hip. Our data do not support the PTH gene as a quantitative trait locus (QTL) underlying the bone phenotypic variation in the Chinese population. © 2003 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAdulten_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshBone And Bones - Radiographyen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoporosis - Ethnology - Geneticsen_US
dc.subject.meshParathyroid Hormone - Geneticsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshQuantitative Trait Locien_US
dc.titleParathyroid hormone gene with bone phenotypes in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-291X(03)01261-0en_US
dc.identifier.pmid12893275-
dc.identifier.scopuseid_2-s2.0-0041669643en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041669643&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume307en_US
dc.identifier.issue3en_US
dc.identifier.spage666en_US
dc.identifier.epage671en_US
dc.identifier.isiWOS:000184509700038-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhou, XG=7410091117en_US
dc.identifier.scopusauthoridLiu, YZ=7410227746en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridJian, WX=7005765053en_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridQin, YJ=7403100918en_US
dc.identifier.scopusauthoridZhou, Q=7402700311en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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