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Article: PGC-1 Coactivators Regulate MITF and the Tanning Response

TitlePGC-1 Coactivators Regulate MITF and the Tanning Response
Authors
Issue Date2013
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/molcel
Citation
Molecular Cell, 2013, v. 49 n. 1, p. 145-157 How to Cite?
AbstractThe production of pigment by melanocytes tans the skin and protects against skin cancers. UV-exposed keratinocytes secrete α-MSH, which then activates melanin formation in melanocytes by inducing the microphthalmia-associated transcription factor (MITF). We show that PPAR-γ coactivator (PGC)-1α and PGC-1β are critical components of this melanogenic system in melanocytes. α-MSH signaling strongly induces PGC-1α expression and stabilizes both PGC-1α and PGC-1β proteins. The PGC-1s in turn activate the MITF promoter, and their expression correlates strongly with that of MITF in human melanoma cell lines and biopsy specimens. Inhibition of PGC-1α and PGC-1β blocks the α-MSH-mediated induction of MITF and melanogenic genes. Conversely, overexpression of PGC-1α induces pigment formation in cell culture and transgenic animals. Finally, polymorphism studies reveal expression quantitative trait loci in the PGC-1β gene that correlate with tanning ability and protection from melanoma in humans. These data identify PGC-1 coactivators as regulators of human tanning. © 2013 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/180756
ISSN
2015 Impact Factor: 13.958
2015 SCImago Journal Rankings: 13.658
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShoag, Jen_US
dc.contributor.authorHaq, Ren_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorLiu, Len_US
dc.contributor.authorRowe, GCen_US
dc.contributor.authorJiang, Aen_US
dc.contributor.authorKoulisis, Nen_US
dc.contributor.authorFarrel, Cen_US
dc.contributor.authorAmos, CIen_US
dc.contributor.authorWei, Qen_US
dc.contributor.authorLee, JEen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorKupper, TSen_US
dc.contributor.authorQureshi, AAen_US
dc.contributor.authorCui, Ren_US
dc.contributor.authorHan, Jen_US
dc.contributor.authorFisher, DEen_US
dc.contributor.authorArany, Zen_US
dc.date.accessioned2013-01-28T01:42:20Z-
dc.date.available2013-01-28T01:42:20Z-
dc.date.issued2013en_US
dc.identifier.citationMolecular Cell, 2013, v. 49 n. 1, p. 145-157en_US
dc.identifier.issn1097-2765en_US
dc.identifier.urihttp://hdl.handle.net/10722/180756-
dc.description.abstractThe production of pigment by melanocytes tans the skin and protects against skin cancers. UV-exposed keratinocytes secrete α-MSH, which then activates melanin formation in melanocytes by inducing the microphthalmia-associated transcription factor (MITF). We show that PPAR-γ coactivator (PGC)-1α and PGC-1β are critical components of this melanogenic system in melanocytes. α-MSH signaling strongly induces PGC-1α expression and stabilizes both PGC-1α and PGC-1β proteins. The PGC-1s in turn activate the MITF promoter, and their expression correlates strongly with that of MITF in human melanoma cell lines and biopsy specimens. Inhibition of PGC-1α and PGC-1β blocks the α-MSH-mediated induction of MITF and melanogenic genes. Conversely, overexpression of PGC-1α induces pigment formation in cell culture and transgenic animals. Finally, polymorphism studies reveal expression quantitative trait loci in the PGC-1β gene that correlate with tanning ability and protection from melanoma in humans. These data identify PGC-1 coactivators as regulators of human tanning. © 2013 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/molcelen_US
dc.relation.ispartofMolecular Cellen_US
dc.titlePGC-1 Coactivators Regulate MITF and the Tanning Responseen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.molcel.2012.10.027en_US
dc.identifier.pmid23201126-
dc.identifier.scopuseid_2-s2.0-84872276087en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84872276087&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue1en_US
dc.identifier.spage145en_US
dc.identifier.epage157en_US
dc.identifier.isiWOS:000313607300014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShoag, J=12753005700en_US
dc.identifier.scopusauthoridHaq, R=55503210700en_US
dc.identifier.scopusauthoridZhang, M=55503132900en_US
dc.identifier.scopusauthoridLiu, L=55218007000en_US
dc.identifier.scopusauthoridRowe, GC=24077557600en_US
dc.identifier.scopusauthoridJiang, A=36616344500en_US
dc.identifier.scopusauthoridKoulisis, N=55217588900en_US
dc.identifier.scopusauthoridFarrel, C=55503226000en_US
dc.identifier.scopusauthoridAmos, CI=55555093400en_US
dc.identifier.scopusauthoridWei, Q=7201691656en_US
dc.identifier.scopusauthoridLee, JE=55555287000en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridKupper, TS=7004395018en_US
dc.identifier.scopusauthoridQureshi, AA=55555299600en_US
dc.identifier.scopusauthoridCui, R=7006666340en_US
dc.identifier.scopusauthoridHan, J=55204992300en_US
dc.identifier.scopusauthoridFisher, DE=55555294900en_US
dc.identifier.scopusauthoridArany, Z=6602384058en_US

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