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- Publisher Website: 10.1111/j.1365-294X.2012.05551.x
- Scopus: eid_2-s2.0-84861574328
- PMID: 22512302
- WOS: WOS:000304389500009
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Article: Innate immunity and the evolution of resistance to an emerging infectious disease in a wild bird
Title | Innate immunity and the evolution of resistance to an emerging infectious disease in a wild bird |
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Authors | |
Keywords | cell-mediated immunity immunosuppression microevolution time-series microarray |
Issue Date | 2012 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MEC |
Citation | Molecular Ecology, 2012, v. 21 n. 11, p. 2628-2639 How to Cite? |
Abstract | Innate immunity is expected to play a primary role in conferring resistance to novel infectious diseases, but few studies have attempted to examine its role in the evolution of resistance to emerging pathogens in wild vertebrate populations. Here, we used experimental infections and cDNA microarrays to examine whether changes in the innate and/or acquired immune responses likely accompanied the emergence of resistance in house finches (Carpodacus mexicanus) in the eastern United States subject to a recent outbreak of conjunctivitis-causing bacterium (Mycoplasma gallisepticum-MG). Three days following experimental infection with MG, we observed differences in the splenic transcriptional responses between house finches from eastern U.S. populations, with a 12-year history of MG exposure, versus western U.S. populations, with no history of exposure to MG. In particular, western birds down-regulated gene expression, while eastern finches showed no expression change relative to controls. Studies involving poultry have shown that MG can manipulate host immunity, and our observations suggest that pathogen manipulation occurred only in finches from the western populations, outside the range of MG. Fourteen days after infection, eastern finches, but not western finches, up-regulated genes associated with acquired immunity (cell-mediated immunity) relative to controls. These observations suggest population differences in the temporal course of the response to infection with MG and imply that innate immune processes were targets of selection in response to MG in the eastern U.S. population. © 2012 Blackwell Publishing Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/180753 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.705 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Bonneaud, C | en_US |
dc.contributor.author | Balenger, SL | en_US |
dc.contributor.author | Zhang, J | en_US |
dc.contributor.author | Edwards, SV | en_US |
dc.contributor.author | Hill, GE | en_US |
dc.date.accessioned | 2013-01-28T01:42:18Z | - |
dc.date.available | 2013-01-28T01:42:18Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Molecular Ecology, 2012, v. 21 n. 11, p. 2628-2639 | en_US |
dc.identifier.issn | 0962-1083 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180753 | - |
dc.description.abstract | Innate immunity is expected to play a primary role in conferring resistance to novel infectious diseases, but few studies have attempted to examine its role in the evolution of resistance to emerging pathogens in wild vertebrate populations. Here, we used experimental infections and cDNA microarrays to examine whether changes in the innate and/or acquired immune responses likely accompanied the emergence of resistance in house finches (Carpodacus mexicanus) in the eastern United States subject to a recent outbreak of conjunctivitis-causing bacterium (Mycoplasma gallisepticum-MG). Three days following experimental infection with MG, we observed differences in the splenic transcriptional responses between house finches from eastern U.S. populations, with a 12-year history of MG exposure, versus western U.S. populations, with no history of exposure to MG. In particular, western birds down-regulated gene expression, while eastern finches showed no expression change relative to controls. Studies involving poultry have shown that MG can manipulate host immunity, and our observations suggest that pathogen manipulation occurred only in finches from the western populations, outside the range of MG. Fourteen days after infection, eastern finches, but not western finches, up-regulated genes associated with acquired immunity (cell-mediated immunity) relative to controls. These observations suggest population differences in the temporal course of the response to infection with MG and imply that innate immune processes were targets of selection in response to MG in the eastern U.S. population. © 2012 Blackwell Publishing Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MEC | en_US |
dc.relation.ispartof | Molecular Ecology | en_US |
dc.subject | cell-mediated immunity | - |
dc.subject | immunosuppression | - |
dc.subject | microevolution | - |
dc.subject | time-series microarray | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Animals, Wild | en_US |
dc.subject.mesh | Biological Evolution | en_US |
dc.subject.mesh | Bird Diseases - Microbiology | en_US |
dc.subject.mesh | Disease Resistance - Genetics - Immunology | en_US |
dc.subject.mesh | Finches - Genetics - Immunology - Microbiology | en_US |
dc.subject.mesh | Gene Expression Regulation | en_US |
dc.subject.mesh | Immunity, Innate - Genetics | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Mycoplasma Infections - Immunology - Veterinary | en_US |
dc.subject.mesh | Mycoplasma Gallisepticum - Pathogenicity | en_US |
dc.subject.mesh | Oligonucleotide Array Sequence Analysis | en_US |
dc.subject.mesh | United States | en_US |
dc.title | Innate immunity and the evolution of resistance to an emerging infectious disease in a wild bird | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhang, J: jzhang1@hku.hk | en_US |
dc.identifier.authority | Zhang, J=rp01713 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1365-294X.2012.05551.x | en_US |
dc.identifier.pmid | 22512302 | - |
dc.identifier.scopus | eid_2-s2.0-84861574328 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84861574328&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 2628 | en_US |
dc.identifier.epage | 2639 | en_US |
dc.identifier.isi | WOS:000304389500009 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Bonneaud, C=6507932232 | en_US |
dc.identifier.scopusauthorid | Balenger, SL=6506097429 | en_US |
dc.identifier.scopusauthorid | Zhang, J=22137260600 | en_US |
dc.identifier.scopusauthorid | Edwards, SV=7401520541 | en_US |
dc.identifier.scopusauthorid | Hill, GE=35500077500 | en_US |
dc.identifier.issnl | 0962-1083 | - |