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Article: Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk

TitleGenome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
Authors
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2011, v. 20 n. 13, p. 2673-2679 How to Cite?
AbstractWe conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identified the nidogen 1 (NID1) gene on 1q42 associated with nevus count (two linked single nucleotide polymorphisms with r 2 > 0.9: rs3768080 A allele associated with reduced count, P = 6.5 × 10 -8; and rs10754833 T allele associated with reduced count, P = 1.5 × 10 -7). We further determined that the rs10754833 [T] was associated with a decreased melanoma risk in 2368 melanoma cases and 7432 controls [for CT genotype: odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.75-0.99, P = 0.04; for TT genotype: OR = 0.84, 95% CI = 0.71-0.98, P = 0.03]. Expression level of the NID1 locus was 2-fold higher for the rs10754833 T allele carriers than that with the CC genotype (P = 0.017) in the 87 HapMap CEU cell lines. The NID1 gene is a biologically plausible locus for nevogenesis and melanoma development, with decreased expression levels of NID1 in benign nevi (P = 3.5 × 10 -6) and in primary melanoma (P = 4.6 × 10 -4) compared with the normal skin. © The Author 2011. Published by Oxford University Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/180748
ISSN
2015 Impact Factor: 5.985
2015 SCImago Journal Rankings: 4.288
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNan, Hen_US
dc.contributor.authorXu, Men_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorQureshi, AAen_US
dc.contributor.authorChen, Cen_US
dc.contributor.authorGuo, Qen_US
dc.contributor.authorHu, FBen_US
dc.contributor.authorRimm, EBen_US
dc.contributor.authorCurhan, Gen_US
dc.contributor.authorSong, Yen_US
dc.contributor.authorAmos, CIen_US
dc.contributor.authorWang, LEen_US
dc.contributor.authorLee, JEen_US
dc.contributor.authorWei, Qen_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorHan, Jen_US
dc.date.accessioned2013-01-28T01:42:15Z-
dc.date.available2013-01-28T01:42:15Z-
dc.date.issued2011en_US
dc.identifier.citationHuman Molecular Genetics, 2011, v. 20 n. 13, p. 2673-2679en_US
dc.identifier.issn0964-6906en_US
dc.identifier.urihttp://hdl.handle.net/10722/180748-
dc.description.abstractWe conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identified the nidogen 1 (NID1) gene on 1q42 associated with nevus count (two linked single nucleotide polymorphisms with r 2 > 0.9: rs3768080 A allele associated with reduced count, P = 6.5 × 10 -8; and rs10754833 T allele associated with reduced count, P = 1.5 × 10 -7). We further determined that the rs10754833 [T] was associated with a decreased melanoma risk in 2368 melanoma cases and 7432 controls [for CT genotype: odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.75-0.99, P = 0.04; for TT genotype: OR = 0.84, 95% CI = 0.71-0.98, P = 0.03]. Expression level of the NID1 locus was 2-fold higher for the rs10754833 T allele carriers than that with the CC genotype (P = 0.017) in the 87 HapMap CEU cell lines. The NID1 gene is a biologically plausible locus for nevogenesis and melanoma development, with decreased expression levels of NID1 in benign nevi (P = 3.5 × 10 -6) and in primary melanoma (P = 4.6 × 10 -4) compared with the normal skin. © The Author 2011. Published by Oxford University Press. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_US
dc.relation.ispartofHuman Molecular Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMelanoma - Geneticsen_US
dc.subject.meshMembrane Glycoproteins - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNevus, Pigmented - Geneticsen_US
dc.subject.meshPolymorphism, Single Nucleotide - Geneticsen_US
dc.subject.meshRisken_US
dc.subject.meshSkin Neoplasms - Geneticsen_US
dc.titleGenome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risken_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/hmg/ddr154en_US
dc.identifier.pmid21478494-
dc.identifier.scopuseid_2-s2.0-79958759586en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958759586&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue13en_US
dc.identifier.spage2673en_US
dc.identifier.epage2679en_US
dc.identifier.isiWOS:000291527000016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNan, H=7003470244en_US
dc.identifier.scopusauthoridXu, M=7403606786en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridZhang, M=35735660000en_US
dc.identifier.scopusauthoridKraft, P=8678864000en_US
dc.identifier.scopusauthoridQureshi, AA=7201433959en_US
dc.identifier.scopusauthoridChen, C=35572871400en_US
dc.identifier.scopusauthoridGuo, Q=55459996500en_US
dc.identifier.scopusauthoridHu, FB=36038688700en_US
dc.identifier.scopusauthoridRimm, EB=7102718317en_US
dc.identifier.scopusauthoridCurhan, G=7006279647en_US
dc.identifier.scopusauthoridSong, Y=8436554700en_US
dc.identifier.scopusauthoridAmos, CI=7103050564en_US
dc.identifier.scopusauthoridWang, LE=7409178893en_US
dc.identifier.scopusauthoridLee, JE=25930386800en_US
dc.identifier.scopusauthoridWei, Q=7201691656en_US
dc.identifier.scopusauthoridHunter, DJ=36064393800en_US
dc.identifier.scopusauthoridHan, J=7406442327en_US

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