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Article: High-resolution analysis of parent-of-origin allelic expression in the mouse brain

TitleHigh-resolution analysis of parent-of-origin allelic expression in the mouse brain
Authors
Issue Date2010
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2010, v. 329 n. 5992, p. 643-648 How to Cite?
AbstractGenomic imprinting results in preferential expression of the paternal or maternal allele of certain genes. We have performed a genome-wide characterization of imprinting in the mouse embryonic and adult brain. This approach uncovered parent-of-origin allelic effects of more than 1300 loci. We identified parental bias in the expression of individual genes and of specific transcript isoforms, with differences between brain regions. Many imprinted genes are expressed in neural systems associated with feeding and motivated behaviors, and parental biases preferentially target genetic pathways governing metabolism and cell adhesion. We observed a preferential maternal contribution to gene expression in the developing brain and a major paternal contribution in the adult brain. Thus, parental expression bias emerges as a major mode of epigenetic regulation in the brain.
Persistent Identifierhttp://hdl.handle.net/10722/180741
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGregg, Cen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorWeissbourd, Ben_US
dc.contributor.authorLuo, Sen_US
dc.contributor.authorSchroth, GPen_US
dc.contributor.authorHaig, Den_US
dc.contributor.authorDulac, Cen_US
dc.date.accessioned2013-01-28T01:42:10Z-
dc.date.available2013-01-28T01:42:10Z-
dc.date.issued2010en_US
dc.identifier.citationScience, 2010, v. 329 n. 5992, p. 643-648en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/180741-
dc.description.abstractGenomic imprinting results in preferential expression of the paternal or maternal allele of certain genes. We have performed a genome-wide characterization of imprinting in the mouse embryonic and adult brain. This approach uncovered parent-of-origin allelic effects of more than 1300 loci. We identified parental bias in the expression of individual genes and of specific transcript isoforms, with differences between brain regions. Many imprinted genes are expressed in neural systems associated with feeding and motivated behaviors, and parental biases preferentially target genetic pathways governing metabolism and cell adhesion. We observed a preferential maternal contribution to gene expression in the developing brain and a major paternal contribution in the adult brain. Thus, parental expression bias emerges as a major mode of epigenetic regulation in the brain.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAllelesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshBrain - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshEpigenesis, Geneticen_US
dc.subject.meshFathersen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshGene Silencingen_US
dc.subject.meshGenomic Imprintingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMothersen_US
dc.subject.meshMultigene Familyen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPrefrontal Cortex - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshPreoptic Area - Embryology - Growth & Development - Metabolismen_US
dc.subject.meshSex Characteristicsen_US
dc.titleHigh-resolution analysis of parent-of-origin allelic expression in the mouse brainen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1190830en_US
dc.identifier.pmid20616232-
dc.identifier.scopuseid_2-s2.0-77955299096en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955299096&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume329en_US
dc.identifier.issue5992en_US
dc.identifier.spage643en_US
dc.identifier.epage648en_US
dc.identifier.isiWOS:000280602700029-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10004303956-
dc.identifier.scopusauthoridGregg, C=34770701300en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridWeissbourd, B=36572913500en_US
dc.identifier.scopusauthoridLuo, S=7401986127en_US
dc.identifier.scopusauthoridSchroth, GP=7102062046en_US
dc.identifier.scopusauthoridHaig, D=7005499789en_US
dc.identifier.scopusauthoridDulac, C=7004206541en_US

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