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Article: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

TitleA coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Authors
Issue Date2010
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2010, v. 465 n. 7301, p. 1033-1038 How to Cite?
AbstractThe canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of their protein-coding function. As a model for the protein-coding-independent role of RNAs, we describe the functional relationship between the mRNAs produced by the PTEN tumour suppressor gene and its pseudogene PTENP1 and the critical consequences of this interaction. We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. We also show that the PTENP1 locus is selectively lost in human cancer. We extended our analysis to other cancer-related genes that possess pseudogenes, such as oncogenic KRAS. We also demonstrate that the transcripts of protein-coding genes such as PTEN are biologically active. These findings attribute a novel biological role to expressed pseudogenes, as they can regulate coding gene expression, and reveal a non-coding function for mRNAs. © 2010 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/180739
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoliseno, Len_US
dc.contributor.authorSalmena, Len_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorCarver, Ben_US
dc.contributor.authorHaveman, WJen_US
dc.contributor.authorPandolfi, PPen_US
dc.date.accessioned2013-01-28T01:42:09Z-
dc.date.available2013-01-28T01:42:09Z-
dc.date.issued2010en_US
dc.identifier.citationNature, 2010, v. 465 n. 7301, p. 1033-1038en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://hdl.handle.net/10722/180739-
dc.description.abstractThe canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of their protein-coding function. As a model for the protein-coding-independent role of RNAs, we describe the functional relationship between the mRNAs produced by the PTEN tumour suppressor gene and its pseudogene PTENP1 and the critical consequences of this interaction. We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. We also show that the PTENP1 locus is selectively lost in human cancer. We extended our analysis to other cancer-related genes that possess pseudogenes, such as oncogenic KRAS. We also demonstrate that the transcripts of protein-coding genes such as PTEN are biologically active. These findings attribute a novel biological role to expressed pseudogenes, as they can regulate coding gene expression, and reveal a non-coding function for mRNAs. © 2010 Macmillan Publishers Limited. All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_US
dc.relation.ispartofNatureen_US
dc.subject.mesh3' Untranslated Regions - Geneticsen_US
dc.subject.meshBinding, Competitiveen_US
dc.subject.meshCell Lineen_US
dc.subject.meshGene Expression Regulation, Neoplastic - Geneticsen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshHumansen_US
dc.subject.meshMicrornas - Geneticsen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshNeoplasms - Geneticsen_US
dc.subject.meshPten Phosphohydrolase - Geneticsen_US
dc.subject.meshProto-Oncogene Proteins - Geneticsen_US
dc.subject.meshPseudogenes - Geneticsen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRas Proteins - Geneticsen_US
dc.titleA coding-independent function of gene and pseudogene mRNAs regulates tumour biologyen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/nature09144en_US
dc.identifier.pmid20577206-
dc.identifier.scopuseid_2-s2.0-77953957633en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953957633&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume465en_US
dc.identifier.issue7301en_US
dc.identifier.spage1033en_US
dc.identifier.epage1038en_US
dc.identifier.isiWOS:000279056900043-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.f10004149957-
dc.identifier.scopusauthoridPoliseno, L=7801522153en_US
dc.identifier.scopusauthoridSalmena, L=6507806834en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridCarver, B=7003593134en_US
dc.identifier.scopusauthoridHaveman, WJ=36106039000en_US
dc.identifier.scopusauthoridPandolfi, PP=7005021176en_US

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