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Article: First-trimester examination of fetal nasal bone in the Chinese population

TitleFirst-trimester examination of fetal nasal bone in the Chinese population
Authors
Issue Date2006
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2006, v. 26 n. 8, p. 703-706 How to Cite?
AbstractObjectives: Absence of the nasal bone in fetuses with trisomy 21 is a potential ultrasound marker for Down syndrome from the first trimester onwards. Racial differences in fetal nasal bone length have been reported. There was no reference range for the first-trimester fetal nasal bone length (NBL) in the Chinese population. Methods: From January 2002 to February 2005, we investigated the reference range of NBL in 2169 singleton fetuses whose parents were Chinese with normal pregnancy outcome. Ultrasound measurements of NBL were performed on a midsagittal plane at 12-14 weeks' gestation. Results: The nasal bone length measurement showed a significant increase with gestational age (GA) (p < 0.05). A linear relationship between nasal bone length and gestational age (NBL = -3.3462 × GA + 0.627, R 2 = 0.30, p < 0.001) as well as a linear relationship between nasal bone length and crown-rump length (CRL) (NBL = 0.3741 × CRL + 0.284, R 2 = 0.30, P < 0.001) was established. Conclusion: The measurement of nasal bone length was feasible in the first trimester. The reference range of NBL in normal Chinese fetuses in the first-trimester of pregnancy was established. This formed a basis for further study on the use of fetal nasal bone measurement in the screening for aneuploidy in the Chinese population. Copyright © 2006 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180681
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Men_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorTang, Ren_US
dc.contributor.authorChan, Ben_US
dc.contributor.authorOu, CQen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:41:04Z-
dc.date.available2013-01-28T01:41:04Z-
dc.date.issued2006en_US
dc.identifier.citationPrenatal Diagnosis, 2006, v. 26 n. 8, p. 703-706en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180681-
dc.description.abstractObjectives: Absence of the nasal bone in fetuses with trisomy 21 is a potential ultrasound marker for Down syndrome from the first trimester onwards. Racial differences in fetal nasal bone length have been reported. There was no reference range for the first-trimester fetal nasal bone length (NBL) in the Chinese population. Methods: From January 2002 to February 2005, we investigated the reference range of NBL in 2169 singleton fetuses whose parents were Chinese with normal pregnancy outcome. Ultrasound measurements of NBL were performed on a midsagittal plane at 12-14 weeks' gestation. Results: The nasal bone length measurement showed a significant increase with gestational age (GA) (p < 0.05). A linear relationship between nasal bone length and gestational age (NBL = -3.3462 × GA + 0.627, R 2 = 0.30, p < 0.001) as well as a linear relationship between nasal bone length and crown-rump length (CRL) (NBL = 0.3741 × CRL + 0.284, R 2 = 0.30, P < 0.001) was established. Conclusion: The measurement of nasal bone length was feasible in the first trimester. The reference range of NBL in normal Chinese fetuses in the first-trimester of pregnancy was established. This formed a basis for further study on the use of fetal nasal bone measurement in the screening for aneuploidy in the Chinese population. Copyright © 2006 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Developmenten_US
dc.subject.meshHumansen_US
dc.subject.meshNasal Bone - Embryology - Ultrasonographyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Firsten_US
dc.subject.meshReference Valuesen_US
dc.subject.meshUltrasonography, Prenatal - Methodsen_US
dc.titleFirst-trimester examination of fetal nasal bone in the Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.1484en_US
dc.identifier.pmid16724362-
dc.identifier.scopuseid_2-s2.0-33747428722en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747428722&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue8en_US
dc.identifier.spage703en_US
dc.identifier.epage706en_US
dc.identifier.isiWOS:000239931300012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, M=8340048100en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridTang, R=7202300287en_US
dc.identifier.scopusauthoridChan, B=7201530637en_US
dc.identifier.scopusauthoridOu, CQ=14070561800en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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