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Article: Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population

TitlePilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population
Authors
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2004, v. 24 n. 2, p. 87-91 How to Cite?
AbstractObjectives: Hypoplasia of the nasal bone of fetuses affected by trisomy 21 and other aneuploidies could be detected by prenatal ultrasound examination and was an important new marker in the detection of Down syndrome in the second trimester. Racial differences in fetal nasal bone length have been reported. However, there was no reference range for the fetal nasal bone length (NBL) in the Chinese population. We conducted a pilot study to investigate the reproducibility of the measurement of fetal NBL in the mid second trimester and to determine whether there is any difference in NBL between the Chinese and the Caucasian population. Methods: From June 2002 to February 2003, 198 Chinese women were examined. Ultrasound measurements of NBL were performed on a strictly midsagittal plane in normal singleton fetuses at 15 to 23 weeks' gestation. Results: The mean difference in the NBL between the two investigators was small (mean = 0.043 mm; 95% CI, -0.033 to 0.12), and there was substantial agreement between the measurements for each observer. Limits of agreement were -0.48 to 0.35 and -0.29 to 0.22 mm in the two investigators respectively. It was found that the median length of the nasal bones increased from 3.5 mm at 15 weeks to 6.7 mm at 23 weeks' gestation. There was a linear relationship between the length of the nasal bone and the gestational age. Conclusion: It was demonstrated that the measurement of nasal bone length was feasible and reproducible in the second trimester. The fetal nasal bone length in Chinese population appeared shorter than that of Caucasian and African-Americans. There is a need to establish a reference range of fetal NBL for the Chinese population. Copyright © 2004 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180672
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Men_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorLeung, KYen_US
dc.contributor.authorHui, PWen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:41:00Z-
dc.date.available2013-01-28T01:41:00Z-
dc.date.issued2004en_US
dc.identifier.citationPrenatal Diagnosis, 2004, v. 24 n. 2, p. 87-91en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180672-
dc.description.abstractObjectives: Hypoplasia of the nasal bone of fetuses affected by trisomy 21 and other aneuploidies could be detected by prenatal ultrasound examination and was an important new marker in the detection of Down syndrome in the second trimester. Racial differences in fetal nasal bone length have been reported. However, there was no reference range for the fetal nasal bone length (NBL) in the Chinese population. We conducted a pilot study to investigate the reproducibility of the measurement of fetal NBL in the mid second trimester and to determine whether there is any difference in NBL between the Chinese and the Caucasian population. Methods: From June 2002 to February 2003, 198 Chinese women were examined. Ultrasound measurements of NBL were performed on a strictly midsagittal plane in normal singleton fetuses at 15 to 23 weeks' gestation. Results: The mean difference in the NBL between the two investigators was small (mean = 0.043 mm; 95% CI, -0.033 to 0.12), and there was substantial agreement between the measurements for each observer. Limits of agreement were -0.48 to 0.35 and -0.29 to 0.22 mm in the two investigators respectively. It was found that the median length of the nasal bones increased from 3.5 mm at 15 weeks to 6.7 mm at 23 weeks' gestation. There was a linear relationship between the length of the nasal bone and the gestational age. Conclusion: It was demonstrated that the measurement of nasal bone length was feasible and reproducible in the second trimester. The fetal nasal bone length in Chinese population appeared shorter than that of Caucasian and African-Americans. There is a need to establish a reference range of fetal NBL for the Chinese population. Copyright © 2004 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChinaen_US
dc.subject.meshDown Syndrome - Diagnosis - Embryology - Ultrasonographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshNasal Bone - Embryology - Ultrasonographyen_US
dc.subject.meshObserver Variationen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Outcomeen_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titlePilot study on the midsecond trimester examination of fetal nasal bone in the Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.793en_US
dc.identifier.pmid14974112-
dc.identifier.scopuseid_2-s2.0-1542351211en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542351211&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue2en_US
dc.identifier.spage87en_US
dc.identifier.epage91en_US
dc.identifier.isiWOS:000189184600003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, M=8340048100en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridLeung, KY=8247106900en_US
dc.identifier.scopusauthoridHui, PW=7101621830en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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