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Article: Can amnio-polymerase chain reaction alone replace conventional cytogenetic study for women with positive biochemical screening for fetal Down syndrome?

TitleCan amnio-polymerase chain reaction alone replace conventional cytogenetic study for women with positive biochemical screening for fetal Down syndrome?
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org
Citation
Obstetrics And Gynecology, 2003, v. 101 n. 5, p. 856-861 How to Cite?
AbstractOBJECTIVE: To determine whether amnio-polymerase chain reaction (amnio-PCR) can replace conventional cytogenetic study for confirming the karyotype of fetuses in women with positive biochemical screening for fetal Down syndrome. METHODS: To check the accuracy of this technique in our laboratory, we first compared the amnio-PCR results with those of conventional cytogenetic study in 235 patients referred from June 1999 to December 2001 for prenatal diagnosis in a referral center in Hong Kong. We then reviewed the results of 1526 amniotic fluid cultures performed for positive fetal Down syndrome screening between January 1997 and December 2001 and classified them as detectable or not detectable by amnio-PCR, using the assumption that we had replaced conventional cytogenetic study with amnio-PCR. RESULTS: The 235 amnio-PCR results were all informative, without a false-positive or false-negative result. Of the 1526 cases with positive fetal Down syndrome screening and no ultrasound abnormalities, only two cases of sex chromosome abnormalities and two cases of marker chromosomes would have been missed if conventional cytogenetic study had been replaced by amnio-PCR. CONCLUSION: Amnio-PCR can be an alternative to conventional cytogenetic study for women with positive biochemical screening for fetal Down syndrome and no demonstrable fetal structural abnormality. © 2003 by The American College of Obstetricians and Gynecologists.
Persistent Identifierhttp://hdl.handle.net/10722/180669
ISSN
2015 Impact Factor: 5.656
2015 SCImago Journal Rankings: 2.899
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WCen_US
dc.contributor.authorLau, ETen_US
dc.contributor.authorLao, TTen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:40:59Z-
dc.date.available2013-01-28T01:40:59Z-
dc.date.issued2003en_US
dc.identifier.citationObstetrics And Gynecology, 2003, v. 101 n. 5, p. 856-861en_US
dc.identifier.issn0029-7844en_US
dc.identifier.urihttp://hdl.handle.net/10722/180669-
dc.description.abstractOBJECTIVE: To determine whether amnio-polymerase chain reaction (amnio-PCR) can replace conventional cytogenetic study for confirming the karyotype of fetuses in women with positive biochemical screening for fetal Down syndrome. METHODS: To check the accuracy of this technique in our laboratory, we first compared the amnio-PCR results with those of conventional cytogenetic study in 235 patients referred from June 1999 to December 2001 for prenatal diagnosis in a referral center in Hong Kong. We then reviewed the results of 1526 amniotic fluid cultures performed for positive fetal Down syndrome screening between January 1997 and December 2001 and classified them as detectable or not detectable by amnio-PCR, using the assumption that we had replaced conventional cytogenetic study with amnio-PCR. RESULTS: The 235 amnio-PCR results were all informative, without a false-positive or false-negative result. Of the 1526 cases with positive fetal Down syndrome screening and no ultrasound abnormalities, only two cases of sex chromosome abnormalities and two cases of marker chromosomes would have been missed if conventional cytogenetic study had been replaced by amnio-PCR. CONCLUSION: Amnio-PCR can be an alternative to conventional cytogenetic study for women with positive biochemical screening for fetal Down syndrome and no demonstrable fetal structural abnormality. © 2003 by The American College of Obstetricians and Gynecologists.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.orgen_US
dc.relation.ispartofObstetrics and Gynecologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshDown Syndrome - Diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titleCan amnio-polymerase chain reaction alone replace conventional cytogenetic study for women with positive biochemical screening for fetal Down syndrome?en_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0029-7844(03)00222-9en_US
dc.identifier.pmid12738140-
dc.identifier.scopuseid_2-s2.0-0038066292en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038066292&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume101en_US
dc.identifier.issue5en_US
dc.identifier.spage856en_US
dc.identifier.epage861en_US
dc.identifier.isiWOS:000182531500006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, WC=7201504435en_US
dc.identifier.scopusauthoridLau, ET=7103086081en_US
dc.identifier.scopusauthoridLao, TT=7005722132en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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