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Article: Prenatal ultrasonographic prediction of homozygous type 1 α- thalassemia at 12 to 13 weeks of gestation

TitlePrenatal ultrasonographic prediction of homozygous type 1 α- thalassemia at 12 to 13 weeks of gestation
Authors
Issue Date1999
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajog
Citation
American Journal Of Obstetrics And Gynecology, 1999, v. 180 n. 1 I, p. 148-150 How to Cite?
AbstractWe determined the feasibility of prenatal prediction of type 1 homozygous α-thalassemia at 12 to 13 weeks of gestation by either abdominal or vaginal (or both) ultrasonographic examination to measure the fetal cardiothoracic ratio in 135 at-risk pregnancies. Forty-three fetuses were affected by homozygous type 1 α-thalassemia. The mean cardiothoracic ratio was significantly larger than that of the unaffected fetuses (0.54 vs 0.45, P < .0005), with no overlap between the 2 groups. A cardiothoracic ratio cutoff point of ≥0.5 was 100% sensitive and specific for disease.
Persistent Identifierhttp://hdl.handle.net/10722/180649
ISSN
2015 Impact Factor: 4.681
2015 SCImago Journal Rankings: 2.255
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorTse, HYen_US
dc.date.accessioned2013-01-28T01:40:52Z-
dc.date.available2013-01-28T01:40:52Z-
dc.date.issued1999en_US
dc.identifier.citationAmerican Journal Of Obstetrics And Gynecology, 1999, v. 180 n. 1 I, p. 148-150en_US
dc.identifier.issn0002-9378en_US
dc.identifier.urihttp://hdl.handle.net/10722/180649-
dc.description.abstractWe determined the feasibility of prenatal prediction of type 1 homozygous α-thalassemia at 12 to 13 weeks of gestation by either abdominal or vaginal (or both) ultrasonographic examination to measure the fetal cardiothoracic ratio in 135 at-risk pregnancies. Forty-three fetuses were affected by homozygous type 1 α-thalassemia. The mean cardiothoracic ratio was significantly larger than that of the unaffected fetuses (0.54 vs 0.45, P < .0005), with no overlap between the 2 groups. A cardiothoracic ratio cutoff point of ≥0.5 was 100% sensitive and specific for disease.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajogen_US
dc.relation.ispartofAmerican Journal of Obstetrics and Gynecologyen_US
dc.subject.meshFeasibility Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Heart - Ultrasonographyen_US
dc.subject.meshForecastingen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshPregnancyen_US
dc.subject.meshThorax - Embryology - Ultrasonographyen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.subject.meshAlpha-Thalassemia - Genetics - Ultrasonographyen_US
dc.titlePrenatal ultrasonographic prediction of homozygous type 1 α- thalassemia at 12 to 13 weeks of gestationen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0002-9378(99)70165-1en_US
dc.identifier.pmid9914594-
dc.identifier.scopuseid_2-s2.0-0033024166en_US
dc.identifier.volume180en_US
dc.identifier.issue1 Ien_US
dc.identifier.spage148en_US
dc.identifier.epage150en_US
dc.identifier.isiWOS:000078224200027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=35362943900en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridTse, HY=36772585300en_US

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