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Article: Risk of neural tube defects in the offspring of Thalassaemia carriers in Hong Kong Chinese

TitleRisk of neural tube defects in the offspring of Thalassaemia carriers in Hong Kong Chinese
Authors
Issue Date1999
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1999, v. 19 n. 12, p. 1135-1137 How to Cite?
AbstractThe risk of having an offspring with neural tube defect is negatively correlated with early pregnancy maternal folate levels. Thalassaemia carriers often have subnormal folate levels. We postulate that their offspring may be at increased risk of having neural tube defect. We retrospectively reviewed the records of 1961 Chinese women referred to a tertiary centre for prenatal diagnosis between January 1997 and August 1998. Women with a mean corpuscular volume greater than 80 fl were assumed not to be α-thalassaemia-1 or β-thalassaemia heterozygotes. α- and β-thalassaemia heterozygotes were diagnosed by haemoglobin studies. Of the 1961 women studied, pregnancy outcome was not available in 20 and thalassaemia screening was not available in 109 and these were excluded from the final analysis. Two-hundred-and-six women were α-thalassaemia-1 heterozygotes, 102 women were β-thalassaemia heterozygotes and one woman had HbE disease. Three α-thalassaemia carriers and one β-thalassaemia carrier had a pregnancy affected by anencephaly (odds = 1:76). In the 1523 non-carriers, five pregnancies were affected by spina bifida (odds = 1:304). The odds ratio (95 per cent confidence interval) for neural tube defects in the α- and β-thalassaemia carriers was 3.99 (1.07 to 14.94; p < 0.05, Chi-square test). Because of the small number of affected pregnancies studied, the finding needs to be substantiated by a larger series. If the increased risk is genuine, women need to be screened for thalassaemia before conception and the thalassaemia carriers should be given periconceptional folate supplement to reduce the occurrence of neural tube defects.
Persistent Identifierhttp://hdl.handle.net/10722/180639
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:40:49Z-
dc.date.available2013-01-28T01:40:49Z-
dc.date.issued1999en_US
dc.identifier.citationPrenatal Diagnosis, 1999, v. 19 n. 12, p. 1135-1137en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180639-
dc.description.abstractThe risk of having an offspring with neural tube defect is negatively correlated with early pregnancy maternal folate levels. Thalassaemia carriers often have subnormal folate levels. We postulate that their offspring may be at increased risk of having neural tube defect. We retrospectively reviewed the records of 1961 Chinese women referred to a tertiary centre for prenatal diagnosis between January 1997 and August 1998. Women with a mean corpuscular volume greater than 80 fl were assumed not to be α-thalassaemia-1 or β-thalassaemia heterozygotes. α- and β-thalassaemia heterozygotes were diagnosed by haemoglobin studies. Of the 1961 women studied, pregnancy outcome was not available in 20 and thalassaemia screening was not available in 109 and these were excluded from the final analysis. Two-hundred-and-six women were α-thalassaemia-1 heterozygotes, 102 women were β-thalassaemia heterozygotes and one woman had HbE disease. Three α-thalassaemia carriers and one β-thalassaemia carrier had a pregnancy affected by anencephaly (odds = 1:76). In the 1523 non-carriers, five pregnancies were affected by spina bifida (odds = 1:304). The odds ratio (95 per cent confidence interval) for neural tube defects in the α- and β-thalassaemia carriers was 3.99 (1.07 to 14.94; p < 0.05, Chi-square test). Because of the small number of affected pregnancies studied, the finding needs to be substantiated by a larger series. If the increased risk is genuine, women need to be screened for thalassaemia before conception and the thalassaemia carriers should be given periconceptional folate supplement to reduce the occurrence of neural tube defects.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshErythrocyte Indicesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshFolic Acid - Blooden_US
dc.subject.meshHeterozygoteen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMedical Recordsen_US
dc.subject.meshNeural Tube Defects - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Outcomeen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThalassemia - Epidemiology - Geneticsen_US
dc.titleRisk of neural tube defects in the offspring of Thalassaemia carriers in Hong Kong Chineseen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0223(199912)19:12<1135::AID-PD720>3.0.CO;2-Ben_US
dc.identifier.pmid10590431-
dc.identifier.scopuseid_2-s2.0-0032721328en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032721328&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue12en_US
dc.identifier.spage1135en_US
dc.identifier.epage1137en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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