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Article: Clinical significance of amniotic-fluid-cell culture failure

TitleClinical significance of amniotic-fluid-cell culture failure
Authors
Issue Date1998
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1998, v. 18 n. 4, p. 343-347 How to Cite?
AbstractRecent reports suggest an increased incidence of chromosomal abnormalities in pregnancies with amniotic fluid-cell culture failure. We retrospectively reviewed the cytogenetic results of 14,165 amniotic fluid samples processed in our laboratory from 1987 to 1996. Ninety-eight per cent of the samples were obtained before 24 weeks' gestation, mainly because of advanced maternal age; 2 per cent were obtained after or at 24 weeks because of the ultrasonographic finding of fetal structural defects. Amniotic-fluid-cell culture failure occurred in 62 cases (0.44 per cent). Culture failure was more common in samples obtained after or at 24 weeks' gestation (10 per cent) than in those obtained before 24 weeks (0.27 per cent) (P < 0.001, chi-square test). This difference was also observed when the results were analysed according to the cases with known normal or abnormal karyotypes. The frequency of culture failure did not differ significantly between the groups with normal and abnormal karyotypes. We conclude that amniotic-fluid-cell culture failure is more common in advanced pregnancy with an ultrasonographic finding of fetal structural defects and is not associated with a higher incidence of chromosomal abnormalities.
Persistent Identifierhttp://hdl.handle.net/10722/180635
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorSin, SYen_US
dc.contributor.authorGhosh, Aen_US
dc.date.accessioned2013-01-28T01:40:48Z-
dc.date.available2013-01-28T01:40:48Z-
dc.date.issued1998en_US
dc.identifier.citationPrenatal Diagnosis, 1998, v. 18 n. 4, p. 343-347en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180635-
dc.description.abstractRecent reports suggest an increased incidence of chromosomal abnormalities in pregnancies with amniotic fluid-cell culture failure. We retrospectively reviewed the cytogenetic results of 14,165 amniotic fluid samples processed in our laboratory from 1987 to 1996. Ninety-eight per cent of the samples were obtained before 24 weeks' gestation, mainly because of advanced maternal age; 2 per cent were obtained after or at 24 weeks because of the ultrasonographic finding of fetal structural defects. Amniotic-fluid-cell culture failure occurred in 62 cases (0.44 per cent). Culture failure was more common in samples obtained after or at 24 weeks' gestation (10 per cent) than in those obtained before 24 weeks (0.27 per cent) (P < 0.001, chi-square test). This difference was also observed when the results were analysed according to the cases with known normal or abnormal karyotypes. The frequency of culture failure did not differ significantly between the groups with normal and abnormal karyotypes. We conclude that amniotic-fluid-cell culture failure is more common in advanced pregnancy with an ultrasonographic finding of fetal structural defects and is not associated with a higher incidence of chromosomal abnormalities.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAmniotic Fluid - Cytologyen_US
dc.subject.meshCell Culture Techniquesen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titleClinical significance of amniotic-fluid-cell culture failureen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0223(199804)18:4<343::AID-PD273>3.0.CO;2-Gen_US
dc.identifier.pmid9602480-
dc.identifier.scopuseid_2-s2.0-0031968758en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031968758&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.spage343en_US
dc.identifier.epage347en_US
dc.identifier.isiWOS:000073579700006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US
dc.identifier.scopusauthoridSin, SY=7006553270en_US
dc.identifier.scopusauthoridGhosh, A=7403963873en_US

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