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postgraduate thesis: The effect of muscimol on the spatial recognition of rats

TitleThe effect of muscimol on the spatial recognition of rats
Authors
Issue Date2012
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Lam, S. K. [林錫峰]. (2012). The effect of muscimol on the spatial recognition of rats. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4854162
AbstractVestibular system (VN) is involved in the spatial recognition of animals. Animals with impaired VN were observed with poor spatial navigation abilities. The purpose of this thesis is to study the effect of muscimol on the spatial recognition of rats. It was found that the neonatal diffusion of muscimol to the VN significantly affected the spatial recognition of rats during dead reckoning test. In the light probe test, which distal visual cues were available, the treated rats spent significantly less time searching for the food pellet (student’s t-test: p<0.001). The return time was significantly higher in treated group than the sham control groupwhen they were tested in in the dark probe test (student’s t-test: p<0.001), which animals were limited to idiothetic cues. Similarly, the heading angles were significantly higher in all three different conditions, light/dark probe and new location tests (light: p<0.001; dark: p<0.001; new location: p<0.01). This finding suggests that neonatal diffusion of muscimol affects the development of vestibular nuclei and that thevestibular system is important for the processing of vestibular informationin spatial recognition.
DegreeMaster of Medical Sciences
SubjectAlkaloids - Physiological effect.
Space perception.
Rats - Physiology.
Dept/ProgramPhysiology
Persistent Identifierhttp://hdl.handle.net/10722/180079

 

DC FieldValueLanguage
dc.contributor.authorLam, Shek-fung, Kenneth.-
dc.contributor.author林錫峰.-
dc.date.accessioned2013-01-17T02:25:03Z-
dc.date.available2013-01-17T02:25:03Z-
dc.date.issued2012-
dc.identifier.citationLam, S. K. [林錫峰]. (2012). The effect of muscimol on the spatial recognition of rats. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4854162-
dc.identifier.urihttp://hdl.handle.net/10722/180079-
dc.description.abstractVestibular system (VN) is involved in the spatial recognition of animals. Animals with impaired VN were observed with poor spatial navigation abilities. The purpose of this thesis is to study the effect of muscimol on the spatial recognition of rats. It was found that the neonatal diffusion of muscimol to the VN significantly affected the spatial recognition of rats during dead reckoning test. In the light probe test, which distal visual cues were available, the treated rats spent significantly less time searching for the food pellet (student’s t-test: p<0.001). The return time was significantly higher in treated group than the sham control groupwhen they were tested in in the dark probe test (student’s t-test: p<0.001), which animals were limited to idiothetic cues. Similarly, the heading angles were significantly higher in all three different conditions, light/dark probe and new location tests (light: p<0.001; dark: p<0.001; new location: p<0.01). This finding suggests that neonatal diffusion of muscimol affects the development of vestibular nuclei and that thevestibular system is important for the processing of vestibular informationin spatial recognition.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.source.urihttp://hub.hku.hk/bib/B4854162X-
dc.subject.lcshAlkaloids - Physiological effect.-
dc.subject.lcshSpace perception.-
dc.subject.lcshRats - Physiology.-
dc.titleThe effect of muscimol on the spatial recognition of rats-
dc.typePG_Thesis-
dc.identifier.hkulb4854162-
dc.description.thesisnameMaster of Medical Sciences-
dc.description.thesislevelMaster-
dc.description.thesisdisciplinePhysiology-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5353/th_b4854162-
dc.date.hkucongregation2012-

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