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Article: Cigarette smoking as a risk factor for influenza-associated mortality: Evidence from an elderly cohort

TitleCigarette smoking as a risk factor for influenza-associated mortality: Evidence from an elderly cohort
Authors
KeywordsCohort
Cox Model
Influenza
Mortality
Smoking
Issue Date2013
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1
Citation
Influenza And Other Respiratory Viruses, 2013, v. 7 n. 4, p. 531-539 How to Cite?
AbstractPlease cite this paper as: Wong et al. (2012) Cigarette smoking as a risk factor for influenza-associated mortality: evidence from an elderly cohort. Influenza and Other Respiratory Viruses DOI:10.1111/j.1750-2659.2012.00411.x. Background The effects of individual lifestyle factors on the mortality risk after influenza infection have not been explored. Objectives In this study, we assessed the modifying effects of cigarette smoking on mortality risks associated with influenza in a cohort of Hong Kong elders with a follow-up period of 1998-2009. Methods We used the Cox proportional hazards model with time-dependent covariates of weekly proportions of specimens positive for influenza (termed as influenza virus activity), to calculate the hazard ratio of mortality associated with a 10% increase in influenza virus activity for never, ex- and current smokers. Other individual lifestyle and socioeconomic factors as well as seasonal confounders were also added into the models. Results The overall hazard ratio associated with influenza was 1·028 (95% confidence interval, 1·006, 1·051) for all natural cause mortality and 1·035 (1·003, 1·068) for cardiovascular and respiratory mortality. We found that influenza-associated hazard ratio was greater in current and ex-smokers than in never smokers for mortality of all natural causes, cardiovascular and respiratory diseases. Conclusions The findings suggest that smoking might increase influenza-associated mortality risks among elders. © 2012 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179839
ISSN
2015 Impact Factor: 2.378
2015 SCImago Journal Rankings: 1.570
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, CMen_US
dc.contributor.authorYang, Len_US
dc.contributor.authorChan, KPen_US
dc.contributor.authorChan, WMen_US
dc.contributor.authorSong, Len_US
dc.contributor.authorLai, HKen_US
dc.contributor.authorThach, TQen_US
dc.contributor.authorHo, LMen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorPeiris, JSMen_US
dc.date.accessioned2012-12-19T10:05:21Z-
dc.date.available2012-12-19T10:05:21Z-
dc.date.issued2013en_US
dc.identifier.citationInfluenza And Other Respiratory Viruses, 2013, v. 7 n. 4, p. 531-539en_US
dc.identifier.issn1750-2640en_US
dc.identifier.urihttp://hdl.handle.net/10722/179839-
dc.description.abstractPlease cite this paper as: Wong et al. (2012) Cigarette smoking as a risk factor for influenza-associated mortality: evidence from an elderly cohort. Influenza and Other Respiratory Viruses DOI:10.1111/j.1750-2659.2012.00411.x. Background The effects of individual lifestyle factors on the mortality risk after influenza infection have not been explored. Objectives In this study, we assessed the modifying effects of cigarette smoking on mortality risks associated with influenza in a cohort of Hong Kong elders with a follow-up period of 1998-2009. Methods We used the Cox proportional hazards model with time-dependent covariates of weekly proportions of specimens positive for influenza (termed as influenza virus activity), to calculate the hazard ratio of mortality associated with a 10% increase in influenza virus activity for never, ex- and current smokers. Other individual lifestyle and socioeconomic factors as well as seasonal confounders were also added into the models. Results The overall hazard ratio associated with influenza was 1·028 (95% confidence interval, 1·006, 1·051) for all natural cause mortality and 1·035 (1·003, 1·068) for cardiovascular and respiratory mortality. We found that influenza-associated hazard ratio was greater in current and ex-smokers than in never smokers for mortality of all natural causes, cardiovascular and respiratory diseases. Conclusions The findings suggest that smoking might increase influenza-associated mortality risks among elders. © 2012 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1en_US
dc.relation.ispartofInfluenza and other Respiratory Virusesen_US
dc.subjectCohorten_US
dc.subjectCox Modelen_US
dc.subjectInfluenzaen_US
dc.subjectMortalityen_US
dc.subjectSmokingen_US
dc.titleCigarette smoking as a risk factor for influenza-associated mortality: Evidence from an elderly cohorten_US
dc.typeArticleen_US
dc.identifier.emailWong, CM: hrmrwcm@hku.hken_US
dc.identifier.emailThach, TQ: thach@hku.hken_US
dc.identifier.emailHo, LM: lmho@hkucc.hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityWong, CM=rp00338en_US
dc.identifier.authorityThach, TQ=rp00450en_US
dc.identifier.authorityHo, LM=rp00360en_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1750-2659.2012.00411.xen_US
dc.identifier.pmid22813463-
dc.identifier.scopuseid_2-s2.0-84879110398en_US
dc.identifier.hkuros224810-
dc.identifier.eissn1750-2659-
dc.identifier.isiWOS:000320277800006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWong, CM=7404954904en_US
dc.identifier.scopusauthoridYang, L=7406279703en_US
dc.identifier.scopusauthoridChan, KP=54921825100en_US
dc.identifier.scopusauthoridChan, WM=55272225900en_US
dc.identifier.scopusauthoridSong, L=55317504400en_US
dc.identifier.scopusauthoridLai, HK=55232754200en_US
dc.identifier.scopusauthoridThach, TQ=6602850066en_US
dc.identifier.scopusauthoridHo, LM=7402955625en_US
dc.identifier.scopusauthoridChan, KH=7406034307en_US
dc.identifier.scopusauthoridLam, TH=7202522876en_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US

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