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Article: Pandemic influenza as a current threat

TitlePandemic influenza as a current threat
Authors
Issue Date2009
Citation
Current Topics In Microbiology And Immunology, 2009, v. 333 n. 1, p. 3-24 How to Cite?
AbstractPandemics of influenza emerge from the aquatic bird reservoir, adapt to humans, modify their severity, and cause seasonal influenza. The catastrophic Spanish H1N1 virus may have obtained all of its eight gene segments from the avian reservoir, whereas the Asian H2N2 and the Hong Kong H3N2 pandemics emerged by reassortment between the circulating human virus and an avian H2 or H3 donor. Of the 16 hemagglutinin subtypes, the H2, H5, H6, H7, and H9 viruses are considered to have pandemic potential. While this chapter focuses on the evolution of the Asian highly pathogenic (HP) H5N1 influenza virus, other subtypes are also considered. The unique features of the HP H5N1 viruses that have devastated the domestic poultry of Eurasia are discussed. Although they transmit poorly to humans, they continue to kill more than 60% of infected persons. It is unknown whether HP H5N1 will acquire human pandemic status; if it does not, another subtype eventually will do so, for a future influenza pandemic is inevitable. © 2009 Springer-Verlag Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/179825
ISSN
2015 Impact Factor: 4.015
2015 SCImago Journal Rankings: 1.824
References

 

DC FieldValueLanguage
dc.contributor.authorYen, HLen_US
dc.contributor.authorWebster, RGen_US
dc.date.accessioned2012-12-19T10:05:14Z-
dc.date.available2012-12-19T10:05:14Z-
dc.date.issued2009en_US
dc.identifier.citationCurrent Topics In Microbiology And Immunology, 2009, v. 333 n. 1, p. 3-24en_US
dc.identifier.issn0070-217Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179825-
dc.description.abstractPandemics of influenza emerge from the aquatic bird reservoir, adapt to humans, modify their severity, and cause seasonal influenza. The catastrophic Spanish H1N1 virus may have obtained all of its eight gene segments from the avian reservoir, whereas the Asian H2N2 and the Hong Kong H3N2 pandemics emerged by reassortment between the circulating human virus and an avian H2 or H3 donor. Of the 16 hemagglutinin subtypes, the H2, H5, H6, H7, and H9 viruses are considered to have pandemic potential. While this chapter focuses on the evolution of the Asian highly pathogenic (HP) H5N1 influenza virus, other subtypes are also considered. The unique features of the HP H5N1 viruses that have devastated the domestic poultry of Eurasia are discussed. Although they transmit poorly to humans, they continue to kill more than 60% of infected persons. It is unknown whether HP H5N1 will acquire human pandemic status; if it does not, another subtype eventually will do so, for a future influenza pandemic is inevitable. © 2009 Springer-Verlag Berlin Heidelberg.en_US
dc.languageengen_US
dc.relation.ispartofCurrent Topics in Microbiology and Immunologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiviral Agents - Therapeutic Useen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshEcologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtypeen_US
dc.subject.meshInfluenza, Human - Drug Therapy - Epidemiologyen_US
dc.subject.meshZoonoses - Epidemiologyen_US
dc.titlePandemic influenza as a current threaten_US
dc.typeArticleen_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/978-3-540-92165-3-1en_US
dc.identifier.pmid19768398-
dc.identifier.scopuseid_2-s2.0-74049093953en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74049093953&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume333en_US
dc.identifier.issue1en_US
dc.identifier.spage3en_US
dc.identifier.epage24en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYen, HL=7102476668en_US
dc.identifier.scopusauthoridWebster, RG=36048363100en_US

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