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Article: Genotypic diversity of H5N1 highly pathogenic avian influenza viruses

TitleGenotypic diversity of H5N1 highly pathogenic avian influenza viruses
Authors
Issue Date2008
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 2008, v. 89 n. 9, p. 2182-2193 How to Cite?
AbstractBesides enomous economic losses to the poultry industry, recent H5N1 highly pathogenic avian influenza viruses (HPAIVs) originating in eastern Asia have posed serious threats to public health. Up to April 17, 2008, 381 human cases had been confirmed with a mortality of more than 60 %. Here, we attempt to identify potential progenitor genes for H5N1 HPAIVs since their first recognition in 1996; most were detected in the Eurasian landmass before 1996. Combinations among these progenitor genes generated at least 21 reassortants (named H5N1 progenitor reassortant, H5N1-PR1-21). H5N1-PR1 includes A/Goose/Guangdong/1/ 1996(H5N1). Only reassortants H5N1-PR2 and H5N1-PR7 were associated with confirmed human cases: H5N1-PR2 in the Hong Kong H5N1 outbreak in 1997 and H5N1-PR7 in laboratory confirmed human cases since 2003. H5N1-PR7 also contains a majority of the H5N1 viruses causing avian influenza outbreaks in birds, including the first wave of genotype Z, Qinghai-like and Fujian-like virus lineages. Among the 21 reassortants edentified, 13 are first reported here. This study illustrates evolutiuonary patterns of H5N1 HPAIVs; which may be useful toward pandemic preparedness as well as avian influenza prevention and control. © 2008 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/179816
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, ZMen_US
dc.contributor.authorShortridge, KFen_US
dc.contributor.authorGarcia, Men_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorWan, XFen_US
dc.date.accessioned2012-12-19T10:05:09Z-
dc.date.available2012-12-19T10:05:09Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of General Virology, 2008, v. 89 n. 9, p. 2182-2193en_US
dc.identifier.issn0022-1317en_US
dc.identifier.urihttp://hdl.handle.net/10722/179816-
dc.description.abstractBesides enomous economic losses to the poultry industry, recent H5N1 highly pathogenic avian influenza viruses (HPAIVs) originating in eastern Asia have posed serious threats to public health. Up to April 17, 2008, 381 human cases had been confirmed with a mortality of more than 60 %. Here, we attempt to identify potential progenitor genes for H5N1 HPAIVs since their first recognition in 1996; most were detected in the Eurasian landmass before 1996. Combinations among these progenitor genes generated at least 21 reassortants (named H5N1 progenitor reassortant, H5N1-PR1-21). H5N1-PR1 includes A/Goose/Guangdong/1/ 1996(H5N1). Only reassortants H5N1-PR2 and H5N1-PR7 were associated with confirmed human cases: H5N1-PR2 in the Hong Kong H5N1 outbreak in 1997 and H5N1-PR7 in laboratory confirmed human cases since 2003. H5N1-PR7 also contains a majority of the H5N1 viruses causing avian influenza outbreaks in birds, including the first wave of genotype Z, Qinghai-like and Fujian-like virus lineages. Among the 21 reassortants edentified, 13 are first reported here. This study illustrates evolutiuonary patterns of H5N1 HPAIVs; which may be useful toward pandemic preparedness as well as avian influenza prevention and control. © 2008 SGM.en_US
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_US
dc.relation.ispartofJournal of General Virologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBirdsen_US
dc.subject.meshGenes, Viralen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Classification - Genetics - Pathogenicityen_US
dc.subject.meshInfluenza In Birds - Virologyen_US
dc.subject.meshInfluenza, Human - Virologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPoultryen_US
dc.subject.meshRecombination, Geneticen_US
dc.subject.meshVirulence - Geneticsen_US
dc.titleGenotypic diversity of H5N1 highly pathogenic avian influenza virusesen_US
dc.typeArticleen_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1099/vir.0.2008/001875-0en_US
dc.identifier.pmid18753228en_US
dc.identifier.scopuseid_2-s2.0-52649132250en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-52649132250&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume89en_US
dc.identifier.issue9en_US
dc.identifier.spage2182en_US
dc.identifier.epage2193en_US
dc.identifier.isiWOS:000259285600015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZhao, ZM=25029392300en_US
dc.identifier.scopusauthoridShortridge, KF=7005677034en_US
dc.identifier.scopusauthoridGarcia, M=7404277348en_US
dc.identifier.scopusauthoridGuan, Y=7202924055en_US
dc.identifier.scopusauthoridWan, XF=9335365800en_US

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