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Article: H5N1 in Asia

TitleH5N1 in Asia
Authors
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/MOVIR
Citation
Monographs In Virology, 2008, v. 27, p. 11-26 How to Cite?
AbstractThe highly pathogenic H5N1 influenza virus that emerged in Southeastern Asia a decade ago has evolved into multiple genetic clades, spread from Asia to Europe and Africa, greatly compromised the poultry industry and endangered human health, and now poses a serious pandemic threat. The unique ecology of the long-established influenza epicenter of Southeastern Asia continues to play a role in driving the genetic diversity and possibly the persistence of H5N1 virus. Long-term surveillance in this region has provided insight into the emergence of H5N1 in Asia, establishment of the virus in this region, and potential routes of spread to other regions. Although highly pathogenic H5N1 virus can be lethal to wild waterfowl, this natural reservoir of all subtypes of influenza A virus is more resistant to the infection and demonstrates the ability to select antigenic variants with attenuated virulence in these species. Other unique characteristics of the H5N1 virus include an expanded host range to many Carnivora species and increased pathogenicity in mammals. Because multiple factors contribute to the spread and perseverance of H5N1 virus, integration of multifaceted strategies and global collaboration are necessary for effective control. © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/179814
ISSN
2015 SCImago Journal Rankings: 0.102
References

 

DC FieldValueLanguage
dc.contributor.authorYen, HLen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorPeiris, Men_US
dc.contributor.authorWebster, RGen_US
dc.date.accessioned2012-12-19T10:05:08Z-
dc.date.available2012-12-19T10:05:08Z-
dc.date.issued2008en_US
dc.identifier.citationMonographs In Virology, 2008, v. 27, p. 11-26en_US
dc.identifier.issn0077-0965en_US
dc.identifier.urihttp://hdl.handle.net/10722/179814-
dc.description.abstractThe highly pathogenic H5N1 influenza virus that emerged in Southeastern Asia a decade ago has evolved into multiple genetic clades, spread from Asia to Europe and Africa, greatly compromised the poultry industry and endangered human health, and now poses a serious pandemic threat. The unique ecology of the long-established influenza epicenter of Southeastern Asia continues to play a role in driving the genetic diversity and possibly the persistence of H5N1 virus. Long-term surveillance in this region has provided insight into the emergence of H5N1 in Asia, establishment of the virus in this region, and potential routes of spread to other regions. Although highly pathogenic H5N1 virus can be lethal to wild waterfowl, this natural reservoir of all subtypes of influenza A virus is more resistant to the infection and demonstrates the ability to select antigenic variants with attenuated virulence in these species. Other unique characteristics of the H5N1 virus include an expanded host range to many Carnivora species and increased pathogenicity in mammals. Because multiple factors contribute to the spread and perseverance of H5N1 virus, integration of multifaceted strategies and global collaboration are necessary for effective control. © 2008 S. Karger AG.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/MOVIRen_US
dc.relation.ispartofMonographs in Virologyen_US
dc.titleH5N1 in Asiaen_US
dc.typeArticleen_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.identifier.authorityPeiris, M=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000151605en_US
dc.identifier.scopuseid_2-s2.0-50549091073en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50549091073&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.spage11en_US
dc.identifier.epage26en_US
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridYen, HL=7102476668en_US
dc.identifier.scopusauthoridGuan, Y=7202924055en_US
dc.identifier.scopusauthoridPeiris, M=7005486823en_US
dc.identifier.scopusauthoridWebster, RG=36048363100en_US

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