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Article: Detection and control of influenza outbreaks in well-vaccinated nursing home populations

TitleDetection and control of influenza outbreaks in well-vaccinated nursing home populations
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2004, v. 39 n. 4, p. 459-464 How to Cite?
AbstractBackground. Influenza outbreaks continue to occur in nursing homes despite high vaccination coverage among residents. Recommendations for outbreak control in institutions such as nursing homes advises use of antiviral drugs to reduce influenza transmission. Methods. Influenza surveillance was performed among elderly residents of nursing homes in Michigan during 2 influenza seasons. The antiviral drug oseltamivir was used for outbreak control at the discretion of nursing home staff once influenza transmission was confirmed by virus isolation or rapid antigen detection. Results. During 2000-2001, influenza was not confirmed in any of the 28 participating homes, despite transmission of types A (H1N1) and B in the community. During 2001-2002, influenza type A (H3N2) transmission was confirmed in 8 (26%) of 31 participating homes; influenza vaccine coverage among residents was 57%-98% in outbreak-associated homes. Oseltamivir was used in all homes with influenza transmission; outbreak control varied according to the rapidity of outbreak recognition and the extent of antiviral use. Reported adverse events were primarily gastrointestinal reactions and rashes. Analysis of the usefulness of rapid antigen detection tests for outbreak recognition indicated a sensitivity of only 77% (specificity, 92%). Conclusions. Oseltamivir was reasonably well tolerated, and its use, along with continued promotion of vaccination coverage among nursing home residents and staff, should be a valuable addition to institutional outbreak-control strategies.
Persistent Identifierhttp://hdl.handle.net/10722/179810
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMonto, ASen_US
dc.contributor.authorRotthoff, Jen_US
dc.contributor.authorTeich, Een_US
dc.contributor.authorHerlocher, MLen_US
dc.contributor.authorTruscon, Ren_US
dc.contributor.authorYen, HLen_US
dc.contributor.authorElias, Sen_US
dc.contributor.authorOhmit, SEen_US
dc.date.accessioned2012-12-19T10:05:02Z-
dc.date.available2012-12-19T10:05:02Z-
dc.date.issued2004en_US
dc.identifier.citationClinical Infectious Diseases, 2004, v. 39 n. 4, p. 459-464en_US
dc.identifier.issn1058-4838en_US
dc.identifier.urihttp://hdl.handle.net/10722/179810-
dc.description.abstractBackground. Influenza outbreaks continue to occur in nursing homes despite high vaccination coverage among residents. Recommendations for outbreak control in institutions such as nursing homes advises use of antiviral drugs to reduce influenza transmission. Methods. Influenza surveillance was performed among elderly residents of nursing homes in Michigan during 2 influenza seasons. The antiviral drug oseltamivir was used for outbreak control at the discretion of nursing home staff once influenza transmission was confirmed by virus isolation or rapid antigen detection. Results. During 2000-2001, influenza was not confirmed in any of the 28 participating homes, despite transmission of types A (H1N1) and B in the community. During 2001-2002, influenza type A (H3N2) transmission was confirmed in 8 (26%) of 31 participating homes; influenza vaccine coverage among residents was 57%-98% in outbreak-associated homes. Oseltamivir was used in all homes with influenza transmission; outbreak control varied according to the rapidity of outbreak recognition and the extent of antiviral use. Reported adverse events were primarily gastrointestinal reactions and rashes. Analysis of the usefulness of rapid antigen detection tests for outbreak recognition indicated a sensitivity of only 77% (specificity, 92%). Conclusions. Oseltamivir was reasonably well tolerated, and its use, along with continued promotion of vaccination coverage among nursing home residents and staff, should be a valuable addition to institutional outbreak-control strategies.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_US
dc.relation.ispartofClinical Infectious Diseasesen_US
dc.subject.meshAcetamides - Adverse Effects - Therapeutic Useen_US
dc.subject.meshAgeden_US
dc.subject.meshAntiviral Agents - Therapeutic Useen_US
dc.subject.meshDiagnostic Techniques And Procedures - Trendsen_US
dc.subject.meshDisease Outbreaks - Prevention & Controlen_US
dc.subject.meshHomes For The Aged - Trendsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization Programs - Trendsen_US
dc.subject.meshInfluenza A Virus - Drug Effects - Immunologyen_US
dc.subject.meshInfluenza B Virus - Drug Effects - Immunologyen_US
dc.subject.meshInfluenza, Human - Drug Therapy - Epidemiology - Prevention & Controlen_US
dc.subject.meshMichigan - Epidemiologyen_US
dc.subject.meshNursing Homes - Trendsen_US
dc.subject.meshObservation - Methodsen_US
dc.subject.meshOseltamiviren_US
dc.subject.meshPopulation Surveillance - Methodsen_US
dc.subject.meshSeasonsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.titleDetection and control of influenza outbreaks in well-vaccinated nursing home populationsen_US
dc.typeArticleen_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/422646en_US
dc.identifier.pmid15356805-
dc.identifier.scopuseid_2-s2.0-4344637608en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4344637608&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue4en_US
dc.identifier.spage459en_US
dc.identifier.epage464en_US
dc.identifier.isiWOS:000223141500004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMonto, AS=7004552306en_US
dc.identifier.scopusauthoridRotthoff, J=6505617314en_US
dc.identifier.scopusauthoridTeich, E=6603121368en_US
dc.identifier.scopusauthoridHerlocher, ML=6602769387en_US
dc.identifier.scopusauthoridTruscon, R=6507370205en_US
dc.identifier.scopusauthoridYen, HL=7102476668en_US
dc.identifier.scopusauthoridElias, S=7102552434en_US
dc.identifier.scopusauthoridOhmit, SE=6604064670en_US

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