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Article: Comparison of the replication of influenza A viruses in Chinese ring-necked pheasants and chukar partridges

TitleComparison of the replication of influenza A viruses in Chinese ring-necked pheasants and chukar partridges
Authors
Issue Date2006
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2006, v. 80 n. 5, p. 2151-2161 How to Cite?
AbstractWe investigated the replication and transmission of avian influenza A viruses in two species thought to be intermediate hosts in the spread of influenza A viruses in live poultry markets: Chinese ring-necked pheasants and chukar partridges. All 15 hemagglutinin subtypes replicated in pheasants, and most subtypes transmitted to naïve contact pheasants, primarily via the fecal-oral route. Many viruses were shed from the gastrointestinal tract of experimentally inoculated pheasants for 14 days or longer. Virus was isolated from the cloacal swabs of one contact pheasant for an unprecedented 45 days. Chukar partridges were less susceptible to infection with avian influenza viruses. The viruses that replicated in chukar partridges were isolated for 7 days after experimental inoculation, predominantly from the respiratory tract. We detected high neutralizing antibody titers with correspondingly low levels of serum hemagglutination inhibition antibody titers in pheasants and chukar partridges when chicken red blood cells were used in serological analyses. When horse erythrocytes were used, antibody titers were comparable to those obtained by using the neutralization assay. More importantly, the results suggested that pheasants can serve as a reservoir of influenza virus. Because of their continuous asymptomatic infection and longer stay in the markets, pheasants are ideal "carriers" of influenza A viruses. Their continued presence in live markets contributes to the perpetuation and genetic interaction of influenza viruses there. On the basis of our findings, it does not make good sense to ban quail but not pheasants from the live markets. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179787
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHumberd, Jen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorWebster, RGen_US
dc.date.accessioned2012-12-19T10:04:42Z-
dc.date.available2012-12-19T10:04:42Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Virology, 2006, v. 80 n. 5, p. 2151-2161en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179787-
dc.description.abstractWe investigated the replication and transmission of avian influenza A viruses in two species thought to be intermediate hosts in the spread of influenza A viruses in live poultry markets: Chinese ring-necked pheasants and chukar partridges. All 15 hemagglutinin subtypes replicated in pheasants, and most subtypes transmitted to naïve contact pheasants, primarily via the fecal-oral route. Many viruses were shed from the gastrointestinal tract of experimentally inoculated pheasants for 14 days or longer. Virus was isolated from the cloacal swabs of one contact pheasant for an unprecedented 45 days. Chukar partridges were less susceptible to infection with avian influenza viruses. The viruses that replicated in chukar partridges were isolated for 7 days after experimental inoculation, predominantly from the respiratory tract. We detected high neutralizing antibody titers with correspondingly low levels of serum hemagglutination inhibition antibody titers in pheasants and chukar partridges when chicken red blood cells were used in serological analyses. When horse erythrocytes were used, antibody titers were comparable to those obtained by using the neutralization assay. More importantly, the results suggested that pheasants can serve as a reservoir of influenza virus. Because of their continuous asymptomatic infection and longer stay in the markets, pheasants are ideal "carriers" of influenza A viruses. Their continued presence in live markets contributes to the perpetuation and genetic interaction of influenza viruses there. On the basis of our findings, it does not make good sense to ban quail but not pheasants from the live markets. Copyright © 2006, American Society for Microbiology. All Rights Reserved.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Viral - Blooden_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshCloaca - Virologyen_US
dc.subject.meshDisease Reservoirsen_US
dc.subject.meshFeces - Virologyen_US
dc.subject.meshHemagglutination Inhibition Testsen_US
dc.subject.meshInfluenza A Virus - Physiologyen_US
dc.subject.meshInfluenza In Birds - Virologyen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshPoultry - Immunology - Virologyen_US
dc.subject.meshVirus Replicationen_US
dc.subject.meshVirus Sheddingen_US
dc.titleComparison of the replication of influenza A viruses in Chinese ring-necked pheasants and chukar partridgesen_US
dc.typeArticleen_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1128/JVI.80.5.2151-2161.2006en_US
dc.identifier.pmid16474123-
dc.identifier.scopuseid_2-s2.0-33144466681en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33144466681&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume80en_US
dc.identifier.issue5en_US
dc.identifier.spage2151en_US
dc.identifier.epage2161en_US
dc.identifier.isiWOS:000235388400009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHumberd, J=6506769380en_US
dc.identifier.scopusauthoridGuan, Y=7202924055en_US
dc.identifier.scopusauthoridWebster, RG=36048363100en_US

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