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Article: Evolution of H5N1 avian influenza viruses in Asia

TitleEvolution of H5N1 avian influenza viruses in Asia
Authors
Issue Date2005
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2005, v. 11 n. 10, p. 1515-1521 How to Cite?
AbstractAn outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused ≥52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.
Persistent Identifierhttp://hdl.handle.net/10722/179785
ISSN
2015 Impact Factor: 6.994
2015 SCImago Journal Rankings: 3.023
References

 

DC FieldValueLanguage
dc.contributor.authorAubin, JTen_US
dc.contributor.authorAzebi, Sen_US
dc.contributor.authorBalish, Aen_US
dc.contributor.authorBanks, Jen_US
dc.contributor.authorBhat, Nen_US
dc.contributor.authorBright, RAen_US
dc.contributor.authorBrown, Ien_US
dc.contributor.authorBuchy, Pen_US
dc.contributor.authorBurguiere, AMen_US
dc.contributor.authorChen, HIen_US
dc.contributor.authorCheng, Pen_US
dc.contributor.authorCox, NJen_US
dc.contributor.authorCrosier, Aen_US
dc.contributor.authorCurns, Aen_US
dc.contributor.authorCuvelier, Fen_US
dc.contributor.authorDeng, Gen_US
dc.contributor.authorDesheva, Jen_US
dc.contributor.authorDesvaux, Sen_US
dc.contributor.authorDiep, NHen_US
dc.contributor.authorDonis, ROen_US
dc.contributor.authorDouglas, Aen_US
dc.contributor.authorDowell, SFen_US
dc.contributor.authorDung, NTen_US
dc.contributor.authorEdwards, Len_US
dc.contributor.authorFukuda, Ken_US
dc.contributor.authorGarten, Ren_US
dc.contributor.authorGovorkova, Een_US
dc.contributor.authorGregory, Ven_US
dc.contributor.authorHampson, Aen_US
dc.contributor.authorHanh, NTHen_US
dc.contributor.authorHarper, Sen_US
dc.contributor.authorHay, Aen_US
dc.contributor.authorHoffmann, Een_US
dc.contributor.authorHulse, Den_US
dc.contributor.authorImai, Men_US
dc.contributor.authorItamura, Sen_US
dc.contributor.authorJadhao, Sen_US
dc.contributor.authorJeannin, Pen_US
dc.contributor.authorKang, Cen_US
dc.contributor.authorKatz, Jen_US
dc.contributor.authorKim, JHen_US
dc.contributor.authorKlimov, Aen_US
dc.contributor.authorKwon, YKen_US
dc.contributor.authorLee, CWen_US
dc.contributor.authorLien, PSen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorLim, Wen_US
dc.contributor.authorLin, YPen_US
dc.contributor.authorLindstom, Sen_US
dc.contributor.authorLoftin, Len_US
dc.contributor.authorMabry, Jen_US
dc.contributor.authorMai, LQen_US
dc.contributor.authorMaines, Ten_US
dc.contributor.authorManuguerra, JCen_US
dc.contributor.authorMase, Men_US
dc.contributor.authorMatsuoka, Yen_US
dc.contributor.authorMccarron, Men_US
dc.contributor.authorMedina, MJen_US
dc.contributor.authorNguyen, Den_US
dc.contributor.authorNinomiya, Aen_US
dc.contributor.authorObuchi, Men_US
dc.contributor.authorOdagiri, Ten_US
dc.contributor.authorPeiris, Men_US
dc.contributor.authorPerdue, MLen_US
dc.contributor.authorReynes, JMen_US
dc.contributor.authorRobertson, Jen_US
dc.contributor.authorRousseaux, Cen_US
dc.contributor.authorSaito, Ten_US
dc.contributor.authorSangkitporn, Sen_US
dc.contributor.authorShaw, Men_US
dc.contributor.authorSimmerman, JMen_US
dc.contributor.authorSlomka, Men_US
dc.contributor.authorSmith, Cen_US
dc.contributor.authorSorn, Sen_US
dc.contributor.authorSpackman, Een_US
dc.contributor.authorStöhr, Ken_US
dc.contributor.authorSuarez, DLen_US
dc.contributor.authorSung, HWen_US
dc.contributor.authorSwayne, DEen_US
dc.contributor.authorTardyPanit, Men_US
dc.contributor.authorTashiro, Men_US
dc.contributor.authorThawatsupha, Pen_US
dc.contributor.authorTumpey, Ten_US
dc.contributor.authorUyeki, Ten_US
dc.contributor.authorVan Tu, Pen_US
dc.contributor.authorVan Der Werf, Sen_US
dc.contributor.authorVong, Sen_US
dc.contributor.authorWebby, Ren_US
dc.contributor.authorWebster, Ren_US
dc.contributor.authorWood, Jen_US
dc.contributor.authorXu, Xen_US
dc.contributor.authorYi, Gen_US
dc.contributor.authorZhang, Wen_US
dc.date.accessioned2012-12-19T10:04:41Z-
dc.date.available2012-12-19T10:04:41Z-
dc.date.issued2005en_US
dc.identifier.citationEmerging Infectious Diseases, 2005, v. 11 n. 10, p. 1515-1521en_US
dc.identifier.issn1080-6040en_US
dc.identifier.urihttp://hdl.handle.net/10722/179785-
dc.description.abstractAn outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused ≥52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.en_US
dc.languageengen_US
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htmen_US
dc.relation.ispartofEmerging Infectious Diseasesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiviral Agents - Therapeutic Useen_US
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshChickensen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Classification - Drug Effects - Geneticsen_US
dc.subject.meshInfluenza Vaccinesen_US
dc.subject.meshInfluenza In Birds - Epidemiology - Virologyen_US
dc.subject.meshInfluenza, Human - Drug Therapy - Epidemiology - Virologyen_US
dc.subject.meshNeuraminidase - Antagonists & Inhibitorsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPoultryen_US
dc.subject.meshPoultry Diseases - Epidemiology - Virologyen_US
dc.titleEvolution of H5N1 avian influenza viruses in Asiaen_US
dc.typeArticleen_US
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_US
dc.identifier.emailYi, G: yguan@hkucc.hku.hken_US
dc.identifier.authorityPeiris, M=rp00410en_US
dc.identifier.authorityYi, G=rp00397en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16318689-
dc.identifier.scopuseid_2-s2.0-25644439259en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-25644439259&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue10en_US
dc.identifier.spage1515en_US
dc.identifier.epage1521en_US
dc.publisher.placeUnited Statesen_US
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dc.identifier.scopusauthoridBanks, J=7202964553en_US
dc.identifier.scopusauthoridBhat, N=12788588300en_US
dc.identifier.scopusauthoridBright, RA=7101791610en_US
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dc.identifier.scopusauthoridBuchy, P=15019240000en_US
dc.identifier.scopusauthoridBurguiere, AM=6602262335en_US
dc.identifier.scopusauthoridChen, HI=8898573000en_US
dc.identifier.scopusauthoridCheng, P=8865849700en_US
dc.identifier.scopusauthoridCox, NJ=35261700100en_US
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dc.identifier.scopusauthoridDesheva, J=15764695400en_US
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dc.identifier.scopusauthoridDiep, NH=55234854700en_US
dc.identifier.scopusauthoridDonis, RO=35261680000en_US
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