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Article: Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template

TitleDirect evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template
Authors
Issue Date1999
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 1999, v. 73 n. 4, p. 3473-3476 How to Cite?
AbstractThe poly(A) tail of influenza virus mRNA is thought to be synthesized by reiterative copying of the U track near the 5' end of the virion RNA template. This has been widely accepted as a plausible hypothesis, but until now there has been no direct experimental evidence for it. Here, we report such direct evidence based on the fact that (i) replacing the U track with an A track directs synthesis of products with poly(U) tails, both in vitro and in vivo, and (ii) interrupting the U track abolishes polyadenylation in vitro.
Persistent Identifierhttp://hdl.handle.net/10722/179763
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, LLMen_US
dc.contributor.authorPritlove, DCen_US
dc.contributor.authorFodor, Een_US
dc.contributor.authorBrownlee, GGen_US
dc.date.accessioned2012-12-19T10:04:24Z-
dc.date.available2012-12-19T10:04:24Z-
dc.date.issued1999en_US
dc.identifier.citationJournal Of Virology, 1999, v. 73 n. 4, p. 3473-3476en_US
dc.identifier.issn0022-538Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179763-
dc.description.abstractThe poly(A) tail of influenza virus mRNA is thought to be synthesized by reiterative copying of the U track near the 5' end of the virion RNA template. This has been widely accepted as a plausible hypothesis, but until now there has been no direct experimental evidence for it. Here, we report such direct evidence based on the fact that (i) replacing the U track with an A track directs synthesis of products with poly(U) tails, both in vitro and in vivo, and (ii) interrupting the U track abolishes polyadenylation in vitro.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_US
dc.relation.ispartofJournal of Virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus - Genetics - Metabolismen_US
dc.subject.meshRna, Messenger - Biosynthesis - Geneticsen_US
dc.subject.meshRna, Viral - Biosynthesis - Geneticsen_US
dc.subject.meshTemplates, Geneticen_US
dc.subject.meshVirion - Geneticsen_US
dc.titleDirect evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA templateen_US
dc.typeArticleen_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10074205-
dc.identifier.scopuseid_2-s2.0-0033015827en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033015827&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume73en_US
dc.identifier.issue4en_US
dc.identifier.spage3473en_US
dc.identifier.epage3476en_US
dc.identifier.isiWOS:000079122400105-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPoon, LLM=7005441747en_US
dc.identifier.scopusauthoridPritlove, DC=6602418386en_US
dc.identifier.scopusauthoridFodor, E=7006539874en_US
dc.identifier.scopusauthoridBrownlee, GG=35994351900en_US

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