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- Publisher Website: 10.4269/ajtmh.1990.42.104
- Scopus: eid_2-s2.0-0025278866
- PMID: 1690521
- WOS: WOS:A1990CT15100002
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Article: Genetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein
Title | Genetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein |
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Authors | |
Issue Date | 1990 |
Publisher | American Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/ |
Citation | American Journal Of Tropical Medicine And Hygiene, 1990, v. 42 n. 2, p. 104-110 How to Cite? |
Abstract | Monoclonal antibodies against variant epitopes of a highly polymorphic protein (PV 200) in schizonts of Plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual P. vivax infections in Sri Lanka. In 9 out of 10 isolates of freshly drawn P. vivax infected blood from different individuals, parasites of only 1 PV 200 serotype was found within each individual infection, even though parasites were serotypically distinct between individuals. In 1 isolate parasite population, 3 distinct PV 200 serotypes were identified. Thus, most P.vivax infections appeared to consist of a single genetically homogeneous population of parasites within the detection limits of the technique. The prevalence of P. vivax infections in an area of malaria transmission in southern Sri Lanka and the densities of oocysts in mosquitoes fed on P. vivax infected individuals indicated that parasite populations would be transmitted many times before encountering parasites of other origins, and that individual populations would tend to reduce to genetic homogeneity during transmission. These expectations are consistent with the high proportion of genetically homogeneous P. vivax isolates observed. |
Persistent Identifier | http://hdl.handle.net/10722/179739 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.834 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Udagama, PV | en_US |
dc.contributor.author | GamageMendis, AC | en_US |
dc.contributor.author | David, PH | en_US |
dc.contributor.author | Peiris, JSM | en_US |
dc.contributor.author | Perera, KLR | en_US |
dc.contributor.author | Mendis, KN | en_US |
dc.contributor.author | Carter, R | en_US |
dc.date.accessioned | 2012-12-19T10:04:12Z | - |
dc.date.available | 2012-12-19T10:04:12Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | American Journal Of Tropical Medicine And Hygiene, 1990, v. 42 n. 2, p. 104-110 | en_US |
dc.identifier.issn | 0002-9637 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179739 | - |
dc.description.abstract | Monoclonal antibodies against variant epitopes of a highly polymorphic protein (PV 200) in schizonts of Plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual P. vivax infections in Sri Lanka. In 9 out of 10 isolates of freshly drawn P. vivax infected blood from different individuals, parasites of only 1 PV 200 serotype was found within each individual infection, even though parasites were serotypically distinct between individuals. In 1 isolate parasite population, 3 distinct PV 200 serotypes were identified. Thus, most P.vivax infections appeared to consist of a single genetically homogeneous population of parasites within the detection limits of the technique. The prevalence of P. vivax infections in an area of malaria transmission in southern Sri Lanka and the densities of oocysts in mosquitoes fed on P. vivax infected individuals indicated that parasite populations would be transmitted many times before encountering parasites of other origins, and that individual populations would tend to reduce to genetic homogeneity during transmission. These expectations are consistent with the high proportion of genetically homogeneous P. vivax isolates observed. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/ | en_US |
dc.relation.ispartof | American Journal of Tropical Medicine and Hygiene | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anopheles - Parasitology | en_US |
dc.subject.mesh | Antibodies, Monoclonal - Immunology | en_US |
dc.subject.mesh | Antigenic Variation | en_US |
dc.subject.mesh | Antigens, Protozoan - Genetics - Immunology | en_US |
dc.subject.mesh | Crosses, Genetic | en_US |
dc.subject.mesh | Epitopes - Genetics - Immunology | en_US |
dc.subject.mesh | Genetic Variation | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Malaria - Epidemiology - Parasitology | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Plasmodium Vivax - Genetics - Immunology | en_US |
dc.subject.mesh | Prevalence | en_US |
dc.subject.mesh | Protozoan Proteins - Genetics - Immunology | en_US |
dc.subject.mesh | Sri Lanka - Epidemiology | en_US |
dc.subject.mesh | Superinfection - Epidemiology | en_US |
dc.title | Genetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein | en_US |
dc.type | Article | en_US |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | en_US |
dc.identifier.authority | Peiris, JSM=rp00410 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4269/ajtmh.1990.42.104 | - |
dc.identifier.pmid | 1690521 | - |
dc.identifier.scopus | eid_2-s2.0-0025278866 | en_US |
dc.identifier.volume | 42 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 104 | en_US |
dc.identifier.epage | 110 | en_US |
dc.identifier.isi | WOS:A1990CT15100002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Udagama, PV=6505767945 | en_US |
dc.identifier.scopusauthorid | GamageMendis, AC=6602495727 | en_US |
dc.identifier.scopusauthorid | David, PH=7201509648 | en_US |
dc.identifier.scopusauthorid | Peiris, JSM=7005486823 | en_US |
dc.identifier.scopusauthorid | Perera, KLR=7005580276 | en_US |
dc.identifier.scopusauthorid | Mendis, KN=7004958149 | en_US |
dc.identifier.scopusauthorid | Carter, R=7402936927 | en_US |
dc.identifier.issnl | 0002-9637 | - |