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Article: Genetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein

TitleGenetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein
Authors
Issue Date1990
PublisherAmerican Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/
Citation
American Journal Of Tropical Medicine And Hygiene, 1990, v. 42 n. 2, p. 104-110 How to Cite?
AbstractMonoclonal antibodies against variant epitopes of a highly polymorphic protein (PV 200) in schizonts of Plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual P. vivax infections in Sri Lanka. In 9 out of 10 isolates of freshly drawn P. vivax infected blood from different individuals, parasites of only 1 PV 200 serotype was found within each individual infection, even though parasites were serotypically distinct between individuals. In 1 isolate parasite population, 3 distinct PV 200 serotypes were identified. Thus, most P.vivax infections appeared to consist of a single genetically homogeneous population of parasites within the detection limits of the technique. The prevalence of P. vivax infections in an area of malaria transmission in southern Sri Lanka and the densities of oocysts in mosquitoes fed on P. vivax infected individuals indicated that parasite populations would be transmitted many times before encountering parasites of other origins, and that individual populations would tend to reduce to genetic homogeneity during transmission. These expectations are consistent with the high proportion of genetically homogeneous P. vivax isolates observed.
Persistent Identifierhttp://hdl.handle.net/10722/179739
ISSN
2015 Impact Factor: 2.453
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorUdagama, PVen_US
dc.contributor.authorGamageMendis, ACen_US
dc.contributor.authorDavid, PHen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorPerera, KLRen_US
dc.contributor.authorMendis, KNen_US
dc.contributor.authorCarter, Ren_US
dc.date.accessioned2012-12-19T10:04:12Z-
dc.date.available2012-12-19T10:04:12Z-
dc.date.issued1990en_US
dc.identifier.citationAmerican Journal Of Tropical Medicine And Hygiene, 1990, v. 42 n. 2, p. 104-110en_US
dc.identifier.issn0002-9637en_US
dc.identifier.urihttp://hdl.handle.net/10722/179739-
dc.description.abstractMonoclonal antibodies against variant epitopes of a highly polymorphic protein (PV 200) in schizonts of Plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual P. vivax infections in Sri Lanka. In 9 out of 10 isolates of freshly drawn P. vivax infected blood from different individuals, parasites of only 1 PV 200 serotype was found within each individual infection, even though parasites were serotypically distinct between individuals. In 1 isolate parasite population, 3 distinct PV 200 serotypes were identified. Thus, most P.vivax infections appeared to consist of a single genetically homogeneous population of parasites within the detection limits of the technique. The prevalence of P. vivax infections in an area of malaria transmission in southern Sri Lanka and the densities of oocysts in mosquitoes fed on P. vivax infected individuals indicated that parasite populations would be transmitted many times before encountering parasites of other origins, and that individual populations would tend to reduce to genetic homogeneity during transmission. These expectations are consistent with the high proportion of genetically homogeneous P. vivax isolates observed.en_US
dc.languageengen_US
dc.publisherAmerican Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/en_US
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygieneen_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnopheles - Parasitologyen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshAntigenic Variationen_US
dc.subject.meshAntigens, Protozoan - Genetics - Immunologyen_US
dc.subject.meshCrosses, Geneticen_US
dc.subject.meshEpitopes - Genetics - Immunologyen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria - Epidemiology - Parasitologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPlasmodium Vivax - Genetics - Immunologyen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProtozoan Proteins - Genetics - Immunologyen_US
dc.subject.meshSri Lanka - Epidemiologyen_US
dc.subject.meshSuperinfection - Epidemiologyen_US
dc.titleGenetic complexity of Plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite proteinen_US
dc.typeArticleen_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1690521-
dc.identifier.scopuseid_2-s2.0-0025278866en_US
dc.identifier.volume42en_US
dc.identifier.issue2en_US
dc.identifier.spage104en_US
dc.identifier.epage110en_US
dc.identifier.isiWOS:A1990CT15100002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridUdagama, PV=6505767945en_US
dc.identifier.scopusauthoridGamageMendis, AC=6602495727en_US
dc.identifier.scopusauthoridDavid, PH=7201509648en_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US
dc.identifier.scopusauthoridPerera, KLR=7005580276en_US
dc.identifier.scopusauthoridMendis, KN=7004958149en_US
dc.identifier.scopusauthoridCarter, R=7402936927en_US

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