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Article: Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI

TitleTime-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI
Authors
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2009, v. 44 n. 1, p. 16-22 How to Cite?
AbstractThe aim of this study was to investigate the relationship between relative cerebral blood flow (δCBF) and relative cerebral metabolic rate of oxygen (δCMRO2) during continuous visual stimulation (21 min at 8 Hz) with fMRI biophysical models by simultaneously measuring of BOLD, CBF and CBV fMRI signals. The δCMRO2 was determined by both a newly calibrated single-compartment model (SCM) and a multi-compartment model (MCM) and was in agreement between these two models (P > 0.5). The duration-varying δCBF and δCMRO2 showed a negative correlation with time (r = - 0.97, P < 0.001); i.e., δCBF declines while δCMRO2 increases during continuous stimulation. This study also illustrated that without properly calibrating the critical parameters employed in the SCM, an incorrect and even an opposite appearance of the flow-metabolism relationship during prolonged visual stimulation (positively linear coupling) can result. The time-dependent negative correlation between flow and metabolism demonstrated in this fMRI study is consistent with a previous PET observation and further supports the view that the increase in CBF is driven by factors other than oxygen demand and the energy demands will eventually require increased aerobic metabolism as stimulation continues. © 2008 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/179528
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, ALen_US
dc.contributor.authorFox, PTen_US
dc.contributor.authorYang, Yen_US
dc.contributor.authorLu, Hen_US
dc.contributor.authorTan, LHen_US
dc.contributor.authorGao, JHen_US
dc.date.accessioned2012-12-19T09:58:13Z-
dc.date.available2012-12-19T09:58:13Z-
dc.date.issued2009en_US
dc.identifier.citationNeuroimage, 2009, v. 44 n. 1, p. 16-22en_US
dc.identifier.issn1053-8119en_US
dc.identifier.urihttp://hdl.handle.net/10722/179528-
dc.description.abstractThe aim of this study was to investigate the relationship between relative cerebral blood flow (δCBF) and relative cerebral metabolic rate of oxygen (δCMRO2) during continuous visual stimulation (21 min at 8 Hz) with fMRI biophysical models by simultaneously measuring of BOLD, CBF and CBV fMRI signals. The δCMRO2 was determined by both a newly calibrated single-compartment model (SCM) and a multi-compartment model (MCM) and was in agreement between these two models (P > 0.5). The duration-varying δCBF and δCMRO2 showed a negative correlation with time (r = - 0.97, P < 0.001); i.e., δCBF declines while δCMRO2 increases during continuous stimulation. This study also illustrated that without properly calibrating the critical parameters employed in the SCM, an incorrect and even an opposite appearance of the flow-metabolism relationship during prolonged visual stimulation (positively linear coupling) can result. The time-dependent negative correlation between flow and metabolism demonstrated in this fMRI study is consistent with a previous PET observation and further supports the view that the increase in CBF is driven by factors other than oxygen demand and the energy demands will eventually require increased aerobic metabolism as stimulation continues. © 2008 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_US
dc.relation.ispartofNeuroImageen_US
dc.subject.meshAdulten_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshCerebrovascular Circulation - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Interpretation, Computer-Assisteden_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshOxygen - Metabolismen_US
dc.subject.meshPhotic Stimulationen_US
dc.subject.meshTimeen_US
dc.subject.meshVisual Cortex - Blood Supply - Metabolismen_US
dc.titleTime-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRIen_US
dc.typeArticleen_US
dc.identifier.emailTan, LH: tanlh@hku.hken_US
dc.identifier.authorityTan, LH=rp01202en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2008.08.029en_US
dc.identifier.pmid18804541-
dc.identifier.scopuseid_2-s2.0-55149116077en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55149116077&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue1en_US
dc.identifier.spage16en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:000262300900003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, AL=16835064700en_US
dc.identifier.scopusauthoridFox, PT=7402680249en_US
dc.identifier.scopusauthoridYang, Y=7409387192en_US
dc.identifier.scopusauthoridLu, H=8386439700en_US
dc.identifier.scopusauthoridTan, LH=7402233462en_US
dc.identifier.scopusauthoridGao, JH=7404475674en_US
dc.identifier.citeulike7475776-

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