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Article: Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats

TitleAnti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats
Authors
KeywordsAnti-Inflammatory Effect
Chronic Pulmonary Neutrophilic Inflammation
Cigarette Smoke
Naringin
Rats
Issue Date2012
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/jmf
Citation
Journal of Medicinal Food, 2012, v. 15 n. 10, p. 894-900 How to Cite?
AbstractNaringin, a well-known flavanone glycoside of grapefruit and citrus fruits, was found to be as an effective anti-inflammatory compound in our previous lipopolysaccharide-induced acute lung injury mouse model via blockading activity of nuclear factor κB. The current study sought to explore the anti-inflammatory effects of naringin on chronic pulmonary neutrophilic inflammation in cigarette smoke (CS)-induced rats. Seventy Sprague-Dawley rats were randomly divided into seven groups to study the effects of CS with or without various concentrations of naringin or saline for 8 weeks. The results revealed that naringin supplementation at 20, 40, and 80mg/kg significantly increased body weight of CS-induced rats as compared to that in the CS group. Moreover, naringin of 20, 40, and 80mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-α and interleukin-8 (IL-8). IL-10 in bronchoalveolar lavage fluid was significantly suppressed after CS exposure, but dose dependently elevated by naringin. The results from hematoxylin and eosin staining revealed that naringin dose dependently reduced CS-induced infiltration of inflammatory cells, thickening of the bronchial wall, and expansion of average alveolar airspace. In conclusion, our data suggest that naringin is an effective anti-inflammatory compound for attenuating chronic pulmonary neutrophilic inflammation in CS-induced rats. © Copyright 2012, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2012.
Persistent Identifierhttp://hdl.handle.net/10722/179468
ISSN
2015 Impact Factor: 1.844
2015 SCImago Journal Rankings: 0.719
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNie, YCen_US
dc.contributor.authorWu, Hen_US
dc.contributor.authorLi, PBen_US
dc.contributor.authorLuo, YLen_US
dc.contributor.authorLong, Ken_US
dc.contributor.authorXie, LMen_US
dc.contributor.authorShen, JGen_US
dc.contributor.authorSu, WWen_US
dc.date.accessioned2012-12-19T09:56:52Z-
dc.date.available2012-12-19T09:56:52Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Medicinal Food, 2012, v. 15 n. 10, p. 894-900en_US
dc.identifier.issn1096-620Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179468-
dc.description.abstractNaringin, a well-known flavanone glycoside of grapefruit and citrus fruits, was found to be as an effective anti-inflammatory compound in our previous lipopolysaccharide-induced acute lung injury mouse model via blockading activity of nuclear factor κB. The current study sought to explore the anti-inflammatory effects of naringin on chronic pulmonary neutrophilic inflammation in cigarette smoke (CS)-induced rats. Seventy Sprague-Dawley rats were randomly divided into seven groups to study the effects of CS with or without various concentrations of naringin or saline for 8 weeks. The results revealed that naringin supplementation at 20, 40, and 80mg/kg significantly increased body weight of CS-induced rats as compared to that in the CS group. Moreover, naringin of 20, 40, and 80mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-α and interleukin-8 (IL-8). IL-10 in bronchoalveolar lavage fluid was significantly suppressed after CS exposure, but dose dependently elevated by naringin. The results from hematoxylin and eosin staining revealed that naringin dose dependently reduced CS-induced infiltration of inflammatory cells, thickening of the bronchial wall, and expansion of average alveolar airspace. In conclusion, our data suggest that naringin is an effective anti-inflammatory compound for attenuating chronic pulmonary neutrophilic inflammation in CS-induced rats. © Copyright 2012, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2012.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/jmfen_US
dc.relation.ispartofJournal of Medicinal Fooden_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [Journal of Medicinal Food] © [2012] [copyright Mary Ann Liebert, Inc.]; [Journal of Medicinal Food] is available online at: http://www.liebertonline.com.-
dc.subjectAnti-Inflammatory Effecten_US
dc.subjectChronic Pulmonary Neutrophilic Inflammationen_US
dc.subjectCigarette Smokeen_US
dc.subjectNaringinen_US
dc.subjectRatsen_US
dc.titleAnti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed ratsen_US
dc.typeArticleen_US
dc.identifier.emailShen, JG: shenjg@hku.hken_US
dc.identifier.authorityShen, JG=rp00487en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1089/jmf.2012.2251en_US
dc.identifier.pmid22985397-
dc.identifier.scopuseid_2-s2.0-84867322341en_US
dc.identifier.hkuros212391-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84867322341&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue10en_US
dc.identifier.spage894en_US
dc.identifier.epage900en_US
dc.identifier.isiWOS:000309651600006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNie, YC=53865296000en_US
dc.identifier.scopusauthoridWu, H=55385799600en_US
dc.identifier.scopusauthoridLi, PB=10141281200en_US
dc.identifier.scopusauthoridLuo, YL=37026466900en_US
dc.identifier.scopusauthoridLong, K=55386144100en_US
dc.identifier.scopusauthoridXie, LM=55324969700en_US
dc.identifier.scopusauthoridShen, JG=7404929947en_US
dc.identifier.scopusauthoridSu, WW=7402010268en_US

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