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Article: Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats

TitleFree and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp
Citation
Progress In Neuro-Psychopharmacology And Biological Psychiatry, 2009, v. 33 n. 8, p. 1458-1463 How to Cite?
AbstractFree and Easy Wanderer Plus (FEWP) is a well-known traditional Chinese medicine that has been shown to be effective in treating various mood disorders. The purpose of the present study was to determine whether FEWP could ameliorate stress-associated behavior in rats. Following the exposure to enhanced single prolonged stress (ESPS) paradigm, consisting of 2-hr constraint, 20-min forced swimming, ether-induced loss of consciousness, and an electric foot shock, animals were administered orally with FEWP (2.5, 5, or 10 mg/kg daily) or vehicle for 2 weeks. Animals were then tested in the open field, elevated plus-maze, and Morris water maze. ESPS exposure resulted in pronounced anxiety-like behavior, without impairing locomotor activity, as indicated by significant decreases of time spent and number of entries into open arms in the elevated plus-maze test, and unaltered distance traveled in the open field test compared to unexposed animals. ESPS-exposed animals also displayed marked cognitive impairments, with significant increases of distance traveled and the escape latency to the underwater platform, and a striking decrease of time spent in the target quadrant with and without the removal of the platform in the water maze test. However, repeated treatment with FEWP, particularly at higher doses, reversed the aforementioned behavioral values in the elevated plus-maze and water maze tests to the levels similar to unexposed animals. These results indicate that FEWP possesses anxiolytic and cognition-improving effects and may be an effective herbal preparation for the treatment of stress-associated conditions, such as posttraumatic stress disorder (PTSD). © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179454
ISSN
2015 Impact Factor: 4.361
2015 SCImago Journal Rankings: 1.794
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, HNen_US
dc.contributor.authorPeng, Yen_US
dc.contributor.authorTan, QRen_US
dc.contributor.authorWang, HHen_US
dc.contributor.authorChen, YCen_US
dc.contributor.authorZhang, RGen_US
dc.contributor.authorWang, ZZen_US
dc.contributor.authorGuo, Len_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorZhang, ZJen_US
dc.date.accessioned2012-12-19T09:56:43Z-
dc.date.available2012-12-19T09:56:43Z-
dc.date.issued2009en_US
dc.identifier.citationProgress In Neuro-Psychopharmacology And Biological Psychiatry, 2009, v. 33 n. 8, p. 1458-1463en_US
dc.identifier.issn0278-5846en_US
dc.identifier.urihttp://hdl.handle.net/10722/179454-
dc.description.abstractFree and Easy Wanderer Plus (FEWP) is a well-known traditional Chinese medicine that has been shown to be effective in treating various mood disorders. The purpose of the present study was to determine whether FEWP could ameliorate stress-associated behavior in rats. Following the exposure to enhanced single prolonged stress (ESPS) paradigm, consisting of 2-hr constraint, 20-min forced swimming, ether-induced loss of consciousness, and an electric foot shock, animals were administered orally with FEWP (2.5, 5, or 10 mg/kg daily) or vehicle for 2 weeks. Animals were then tested in the open field, elevated plus-maze, and Morris water maze. ESPS exposure resulted in pronounced anxiety-like behavior, without impairing locomotor activity, as indicated by significant decreases of time spent and number of entries into open arms in the elevated plus-maze test, and unaltered distance traveled in the open field test compared to unexposed animals. ESPS-exposed animals also displayed marked cognitive impairments, with significant increases of distance traveled and the escape latency to the underwater platform, and a striking decrease of time spent in the target quadrant with and without the removal of the platform in the water maze test. However, repeated treatment with FEWP, particularly at higher doses, reversed the aforementioned behavioral values in the elevated plus-maze and water maze tests to the levels similar to unexposed animals. These results indicate that FEWP possesses anxiolytic and cognition-improving effects and may be an effective herbal preparation for the treatment of stress-associated conditions, such as posttraumatic stress disorder (PTSD). © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbpen_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.rightsProgress in Neuro-Psychopharmacology & Biological Psychiatry. Copyright © Elsevier Inc.-
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Anxiety Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshBehavior, Animal - Drug Effectsen_US
dc.subject.meshCognition Disorders - Drug Therapy - Etiologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacology - Therapeutic Useen_US
dc.subject.meshExploratory Behavior - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMaze Learning - Drug Effectsen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpatial Behavior - Drug Effectsen_US
dc.subject.meshStress Disorders, Post-Traumatic - Drug Therapy - Etiologyen_US
dc.subject.meshStress, Psychological - Complicationsen_US
dc.titleFree and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed ratsen_US
dc.typeArticleen_US
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_US
dc.identifier.authorityZhang, ZJ=rp01297en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.pnpbp.2009.07.031en_US
dc.identifier.pmid19665511-
dc.identifier.scopuseid_2-s2.0-71549119157en_US
dc.identifier.hkuros174209-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-71549119157&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue8en_US
dc.identifier.spage1458en_US
dc.identifier.epage1463en_US
dc.identifier.isiWOS:000272767100022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, HN=35109844400en_US
dc.identifier.scopusauthoridPeng, Y=34870185600en_US
dc.identifier.scopusauthoridTan, QR=7102120177en_US
dc.identifier.scopusauthoridWang, HH=10144885500en_US
dc.identifier.scopusauthoridChen, YC=22833345400en_US
dc.identifier.scopusauthoridZhang, RG=7404865068en_US
dc.identifier.scopusauthoridWang, ZZ=35109815300en_US
dc.identifier.scopusauthoridGuo, L=55205243200en_US
dc.identifier.scopusauthoridLiu, Y=26642953800en_US
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_US
dc.identifier.citeulike5417409-

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