File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Adjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study

TitleAdjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study
Authors
Issue Date2007
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
Citation
Journal Of Psychiatric Research, 2007, v. 41 n. 3-4, p. 360-369 How to Cite?
AbstractChinese herbal medicines possess the therapeutic potential for mood disorders. This double-blind, randomized, placebo-controlled study was designed to evaluate the efficacy and side effects of the herbal medicine called Free and Easy Wanderer Plus (FEWP) as an adjunct to carbamazepine (CBZ) in patients with bipolar disorders. One hundred and twenty-four bipolar depressed and 111 manic patients were randomized to treatment with CBZ alone, CBZ plus FEWP, or equivalent placebo for 12 weeks. CBZ was initiated at 300 mg/day and FEWP was given at a fixed dose of 36 g/day. Efficacy measures included the Hamilton Rating Scale for Depression, Montgomery-Asberg Depression Rating Scale, Young Mania Rating Scale, Bech-Rafaelsen Mania Scale, and Clinical Global Impression-Severity (CGI-S). CBZ monotherapy produced significantly greater improvement on manic measures at week 2 through endpoint and CGI-S of depression at endpoint compared to placebo. CBZ monotherapy also yielded significantly higher clinical response rates than placebo on bipolar depression (63.8% vs. 34.8%, p = 0.044) and mania (87.8% vs. 57.1%, p = 0.012). Compared to CBZ monotherapy, adjunctive FEWP with CBZ resulted in significantly better outcomes on the three measures of depression at week 4 and week 8 and significantly greater clinical response rate in depressed subjects (84.8% vs. 63.8%, p = 0.032), but failed to produce significantly greater improvement on manic measures and the response rate in manic subjects. There was a lesser incidence of dizziness and fatigue in the combination therapy compared to CBZ monotherapy. These results suggest that adjunctive FEWP has additive beneficial effects in bipolar patients, particularly for those in depressive phase. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179438
ISSN
2015 Impact Factor: 4.465
2015 SCImago Journal Rankings: 2.265
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorKang, WHen_US
dc.contributor.authorTan, QRen_US
dc.contributor.authorLi, Qen_US
dc.contributor.authorGao, CGen_US
dc.contributor.authorZhang, FGen_US
dc.contributor.authorWang, HHen_US
dc.contributor.authorMa, XCen_US
dc.contributor.authorChen, Cen_US
dc.contributor.authorWang, Wen_US
dc.contributor.authorGuo, Len_US
dc.contributor.authorZhang, YHen_US
dc.contributor.authorYang, XBen_US
dc.contributor.authorYang, GDen_US
dc.date.accessioned2012-12-19T09:56:35Z-
dc.date.available2012-12-19T09:56:35Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Psychiatric Research, 2007, v. 41 n. 3-4, p. 360-369en_US
dc.identifier.issn0022-3956en_US
dc.identifier.urihttp://hdl.handle.net/10722/179438-
dc.description.abstractChinese herbal medicines possess the therapeutic potential for mood disorders. This double-blind, randomized, placebo-controlled study was designed to evaluate the efficacy and side effects of the herbal medicine called Free and Easy Wanderer Plus (FEWP) as an adjunct to carbamazepine (CBZ) in patients with bipolar disorders. One hundred and twenty-four bipolar depressed and 111 manic patients were randomized to treatment with CBZ alone, CBZ plus FEWP, or equivalent placebo for 12 weeks. CBZ was initiated at 300 mg/day and FEWP was given at a fixed dose of 36 g/day. Efficacy measures included the Hamilton Rating Scale for Depression, Montgomery-Asberg Depression Rating Scale, Young Mania Rating Scale, Bech-Rafaelsen Mania Scale, and Clinical Global Impression-Severity (CGI-S). CBZ monotherapy produced significantly greater improvement on manic measures at week 2 through endpoint and CGI-S of depression at endpoint compared to placebo. CBZ monotherapy also yielded significantly higher clinical response rates than placebo on bipolar depression (63.8% vs. 34.8%, p = 0.044) and mania (87.8% vs. 57.1%, p = 0.012). Compared to CBZ monotherapy, adjunctive FEWP with CBZ resulted in significantly better outcomes on the three measures of depression at week 4 and week 8 and significantly greater clinical response rate in depressed subjects (84.8% vs. 63.8%, p = 0.032), but failed to produce significantly greater improvement on manic measures and the response rate in manic subjects. There was a lesser incidence of dizziness and fatigue in the combination therapy compared to CBZ monotherapy. These results suggest that adjunctive FEWP has additive beneficial effects in bipolar patients, particularly for those in depressive phase. © 2005 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychiresen_US
dc.relation.ispartofJournal of Psychiatric Researchen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnalgesics, Non-Narcotic - Therapeutic Useen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBipolar Disorder - Drug Therapyen_US
dc.subject.meshCarbamazepine - Therapeutic Useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshDrugs, Chinese Herbal - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAdjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled studyen_US
dc.typeArticleen_US
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_US
dc.identifier.authorityZhang, ZJ=rp01297en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jpsychires.2005.06.002en_US
dc.identifier.pmid16081106-
dc.identifier.scopuseid_2-s2.0-33845229579en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845229579&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue3-4en_US
dc.identifier.spage360en_US
dc.identifier.epage369en_US
dc.identifier.isiWOS:000243214000022-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_US
dc.identifier.scopusauthoridKang, WH=10143941200en_US
dc.identifier.scopusauthoridTan, QR=7102120177en_US
dc.identifier.scopusauthoridLi, Q=36072924100en_US
dc.identifier.scopusauthoridGao, CG=7402617437en_US
dc.identifier.scopusauthoridZhang, FG=10139179000en_US
dc.identifier.scopusauthoridWang, HH=10144885500en_US
dc.identifier.scopusauthoridMa, XC=7404550515en_US
dc.identifier.scopusauthoridChen, C=7501960483en_US
dc.identifier.scopusauthoridWang, W=7501760667en_US
dc.identifier.scopusauthoridGuo, L=55205243200en_US
dc.identifier.scopusauthoridZhang, YH=7601335373en_US
dc.identifier.scopusauthoridYang, XB=35316636600en_US
dc.identifier.scopusauthoridYang, GD=8627524400en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats