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Article: Protective and therapeutic effects of Shugan Lifei Recipe on rats with asthma under stress and the mechanisms

TitleProtective and therapeutic effects of Shugan Lifei Recipe on rats with asthma under stress and the mechanisms
疏肝理肺方防治應激條件下大鼠哮喘的作用機制研究
Authors
Issue Date2005
PublisherJCIM Press. The Journal's web site is located at http://www.jcimjournal.com
Citation
Zhong Xi Yi Jie He Xue Bao = Journal Of Chinese Integrative Medicine., 2005, v. 3 n. 5, p. 391-396 How to Cite?
中西醫結合學報, 2005, v. 3 n. 5, p. 391-396 How to Cite?
AbstractOBJECTIVE: To explore the influence of psychological factor on asthma, the protective and therapeutic effects of Shugan Lifei Recipe on rats with asthma under stress and the mechanisms. METHODS: Allergy and stress-induced asthma models were established in rats by giving ovalbumin and restraining stress. Radioimmunoassay, enzyme linked immunosorbent assay, in situ hybridization and immunohistochemical method were used to detect plasma corticosterone, IL-4, IFN-gamma, expression of glucocorticoid receptor (GR) mRNA in hippocampus and adrenocorticotropic hormone corticoliberin (CRH) positive neuron in hypothalamus. Optical and electron microscopes were used to observe the morphological changes of pulmonary hilar and hippocampal tissues. RESULTS: Shugan Lifei Recipe (SGLFR) could reduce plasma corticosterone, decrease CRH positive neurons in paraventricular nucleus of hypothalamus, up-regulate the expression of GR mRNA in hippocampus and reduce the injury of hippocampal neuron. SGLFR had certain inhibitive effect on hyperfunction of hypothalamo-pituitary-adrenal cortex (HPA) axis in rats with asthma under stress and could also relieve the pathological changes of the pulmonary hilar tissue. The level of plasma IFN-gamma was increased while the level of plasma IL-4 was decreased in SGLFR-treated group. CONCLUSION: The mechanism of SGLFR in treating the rats with asthma under stress is probably to regulate the hyperfunction of HPA axis and the disorder of immuo-system.
Persistent Identifierhttp://hdl.handle.net/10722/179432
ISSN

 

DC FieldValueLanguage
dc.contributor.authorTong, Yen_US
dc.contributor.authorZhang, NXen_US
dc.contributor.authorChen, HJen_US
dc.contributor.authorNi, LQen_US
dc.date.accessioned2012-12-19T09:56:27Z-
dc.date.available2012-12-19T09:56:27Z-
dc.date.issued2005en_US
dc.identifier.citationZhong Xi Yi Jie He Xue Bao = Journal Of Chinese Integrative Medicine., 2005, v. 3 n. 5, p. 391-396en_US
dc.identifier.citation中西醫結合學報, 2005, v. 3 n. 5, p. 391-396-
dc.identifier.issn1672-1977en_US
dc.identifier.urihttp://hdl.handle.net/10722/179432-
dc.description.abstractOBJECTIVE: To explore the influence of psychological factor on asthma, the protective and therapeutic effects of Shugan Lifei Recipe on rats with asthma under stress and the mechanisms. METHODS: Allergy and stress-induced asthma models were established in rats by giving ovalbumin and restraining stress. Radioimmunoassay, enzyme linked immunosorbent assay, in situ hybridization and immunohistochemical method were used to detect plasma corticosterone, IL-4, IFN-gamma, expression of glucocorticoid receptor (GR) mRNA in hippocampus and adrenocorticotropic hormone corticoliberin (CRH) positive neuron in hypothalamus. Optical and electron microscopes were used to observe the morphological changes of pulmonary hilar and hippocampal tissues. RESULTS: Shugan Lifei Recipe (SGLFR) could reduce plasma corticosterone, decrease CRH positive neurons in paraventricular nucleus of hypothalamus, up-regulate the expression of GR mRNA in hippocampus and reduce the injury of hippocampal neuron. SGLFR had certain inhibitive effect on hyperfunction of hypothalamo-pituitary-adrenal cortex (HPA) axis in rats with asthma under stress and could also relieve the pathological changes of the pulmonary hilar tissue. The level of plasma IFN-gamma was increased while the level of plasma IL-4 was decreased in SGLFR-treated group. CONCLUSION: The mechanism of SGLFR in treating the rats with asthma under stress is probably to regulate the hyperfunction of HPA axis and the disorder of immuo-system.en_US
dc.languagechien_US
dc.publisherJCIM Press. The Journal's web site is located at http://www.jcimjournal.comen_US
dc.relation.ispartofZhong xi yi jie he xue bao = Journal of Chinese integrative medicine.en_US
dc.relation.ispartof中西醫結合學報-
dc.subject.meshAnimalsen_US
dc.subject.meshAsthma - Drug Therapy - Etiologyen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacology - Therapeutic Useen_US
dc.subject.meshHypothalamo-Hypophyseal System - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPituitary-Adrenal System - Drug Effects - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Glucocorticoid - Biosynthesis - Geneticsen_US
dc.subject.meshStress, Physiologicalen_US
dc.titleProtective and therapeutic effects of Shugan Lifei Recipe on rats with asthma under stress and the mechanismsen_US
dc.title疏肝理肺方防治應激條件下大鼠哮喘的作用機制研究-
dc.typeArticleen_US
dc.identifier.emailTong, Y: tongyao@hku.hken_US
dc.identifier.authorityTong, Y=rp00509en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16159576-
dc.identifier.scopuseid_2-s2.0-33645456676en_US
dc.identifier.hkuros137060-
dc.identifier.volume3en_US
dc.identifier.issue5en_US
dc.identifier.spage391en_US
dc.identifier.epage396en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridTong, Y=9045384000en_US
dc.identifier.scopusauthoridZhang, NX=12798248800en_US
dc.identifier.scopusauthoridChen, HJ=38163238900en_US
dc.identifier.scopusauthoridNi, LQ=9036497400en_US

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