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Article: Differences in hypothyroidism between lithium-free and -treated patients with bipolar disorders

TitleDifferences in hypothyroidism between lithium-free and -treated patients with bipolar disorders
Authors
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2006, v. 78 n. 7, p. 771-776 How to Cite?
AbstractThe majority of the previous studies of thyroid abnormalities in bipolar patients was conducted in populations containing various proportions of lithium-treated subjects. In the present study, we sought to determine whether there exist differences in hypothyroid profile between lithium-free and -treated bipolar patients. Bipolar patients never treated with lithium and carbamazepine (n = 78) and those currently in lithium therapy (n = 53) were included in this study. Serum concentrations of total thyroxine (T4), total triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were compared between lithium-free and -treated patients. The rate of hypothyroidism in lithium-free patients was significantly lower than those treated with lithium (6.3%-10.8% vs. 28.0%-32.1%). Significant changes in the three thyroid indices indicative of hypothyroidism were consistently associated with longer illness duration in lithium-free manic patients, but with greater severity of mania and more mood episodes in their lithium-treated counterparts. In lithium-free depressed patients, more episodes were associated with lower T4 levels; whereas in their lithium-treated counterparts, longer illness duration was associated with higher TSH levels and females with lower T3 levels. These results suggest that bipolar patients with and without lithium exposure differ in prevalence and association of hypothyroidism and may have different response to thyroid hormone therapy. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179427
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorQiang Lien_US
dc.contributor.authorKang, WHen_US
dc.contributor.authorTan, QRen_US
dc.contributor.authorGao, CGen_US
dc.contributor.authorZhang, FGen_US
dc.contributor.authorWang, HHen_US
dc.contributor.authorMa, XCen_US
dc.contributor.authorCe Chenen_US
dc.contributor.authorWei Wangen_US
dc.contributor.authorLi Guoen_US
dc.contributor.authorZhang, YHen_US
dc.contributor.authorYang, XBen_US
dc.contributor.authorZhang, RGen_US
dc.date.accessioned2012-12-19T09:56:23Z-
dc.date.available2012-12-19T09:56:23Z-
dc.date.issued2006en_US
dc.identifier.citationLife Sciences, 2006, v. 78 n. 7, p. 771-776en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/179427-
dc.description.abstractThe majority of the previous studies of thyroid abnormalities in bipolar patients was conducted in populations containing various proportions of lithium-treated subjects. In the present study, we sought to determine whether there exist differences in hypothyroid profile between lithium-free and -treated bipolar patients. Bipolar patients never treated with lithium and carbamazepine (n = 78) and those currently in lithium therapy (n = 53) were included in this study. Serum concentrations of total thyroxine (T4), total triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were compared between lithium-free and -treated patients. The rate of hypothyroidism in lithium-free patients was significantly lower than those treated with lithium (6.3%-10.8% vs. 28.0%-32.1%). Significant changes in the three thyroid indices indicative of hypothyroidism were consistently associated with longer illness duration in lithium-free manic patients, but with greater severity of mania and more mood episodes in their lithium-treated counterparts. In lithium-free depressed patients, more episodes were associated with lower T4 levels; whereas in their lithium-treated counterparts, longer illness duration was associated with higher TSH levels and females with lower T3 levels. These results suggest that bipolar patients with and without lithium exposure differ in prevalence and association of hypothyroidism and may have different response to thyroid hormone therapy. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshAdulten_US
dc.subject.meshAntimanic Agents - Therapeutic Useen_US
dc.subject.meshBipolar Disorder - Complications - Diagnosis - Drug Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism - Complications - Diagnosisen_US
dc.subject.meshLithium Carbonate - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.titleDifferences in hypothyroidism between lithium-free and -treated patients with bipolar disordersen_US
dc.typeArticleen_US
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_US
dc.identifier.authorityZhang, ZJ=rp01297en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.lfs.2005.05.090en_US
dc.identifier.pmid16137715-
dc.identifier.scopuseid_2-s2.0-29244477980en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29244477980&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue7en_US
dc.identifier.spage771en_US
dc.identifier.epage776en_US
dc.identifier.isiWOS:000234700700015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_US
dc.identifier.scopusauthoridQiang Li=10141754600en_US
dc.identifier.scopusauthoridKang, WH=10143941200en_US
dc.identifier.scopusauthoridTan, QR=7102120177en_US
dc.identifier.scopusauthoridGao, CG=7402617437en_US
dc.identifier.scopusauthoridZhang, FG=10139179000en_US
dc.identifier.scopusauthoridWang, HH=10144885500en_US
dc.identifier.scopusauthoridMa, XC=7404550515en_US
dc.identifier.scopusauthoridCe Chen=10139573700en_US
dc.identifier.scopusauthoridWei Wang=10140002700en_US
dc.identifier.scopusauthoridLi Guo=10144542200en_US
dc.identifier.scopusauthoridZhang, YH=7601335373en_US
dc.identifier.scopusauthoridYang, XB=35316636600en_US
dc.identifier.scopusauthoridZhang, RG=7404865068en_US

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