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Article: The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm

TitleThe paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2005, v. 382 n. 1-2, p. 134-138 How to Cite?
AbstractWhile the benzazepine SKF83959 elicits classical behavioral responses associated with dopamine D1 receptors, it also acts as a D 1 receptor antagonist biochemically. The paradoxical properties of this agent remain an enigma. In the present study, we sought to determine the behavioral effects of SKF83959 in the rat acoustic startle reflex test. Systemic administration of SKF83959 produced a dose-related increase in the startle amplitude with a stimulus of 105 dB, and a significant group difference was observed between animals treated with 1 mg/kg SKF83959 and vehicle controls. SKF83959 also significantly reduced the latency to startle response to stimuli of 95 dB and 105 dB in a dose-dependent manner. However, unlike classical dopamine D1-like receptor agonists, SKF83959 failed to disrupt prepulse inhibition (PPI) of either the startle amplitude or the latency to startle response; rather, the agent dose-dependently increased the PPI latency to startle response of 105 dB stimulus. These results suggest that the behavioral effects of SKF83959 in the rat acoustic startle reflex paradigm are paradoxical, and these paradoxical effects may be associated with its distinct pharmacological properties. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179424
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorJiang, XLen_US
dc.contributor.authorZhang, SEen_US
dc.contributor.authorHough, CJen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorChen, JGen_US
dc.contributor.authorZhen, XCen_US
dc.date.accessioned2012-12-19T09:56:21Z-
dc.date.available2012-12-19T09:56:21Z-
dc.date.issued2005en_US
dc.identifier.citationNeuroscience Letters, 2005, v. 382 n. 1-2, p. 134-138en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/179424-
dc.description.abstractWhile the benzazepine SKF83959 elicits classical behavioral responses associated with dopamine D1 receptors, it also acts as a D 1 receptor antagonist biochemically. The paradoxical properties of this agent remain an enigma. In the present study, we sought to determine the behavioral effects of SKF83959 in the rat acoustic startle reflex test. Systemic administration of SKF83959 produced a dose-related increase in the startle amplitude with a stimulus of 105 dB, and a significant group difference was observed between animals treated with 1 mg/kg SKF83959 and vehicle controls. SKF83959 also significantly reduced the latency to startle response to stimuli of 95 dB and 105 dB in a dose-dependent manner. However, unlike classical dopamine D1-like receptor agonists, SKF83959 failed to disrupt prepulse inhibition (PPI) of either the startle amplitude or the latency to startle response; rather, the agent dose-dependently increased the PPI latency to startle response of 105 dB stimulus. These results suggest that the behavioral effects of SKF83959 in the rat acoustic startle reflex paradigm are paradoxical, and these paradoxical effects may be associated with its distinct pharmacological properties. © 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.mesh2,3,4,5-Tetrahydro-7,8-Dihydroxy-1-Phenyl-1H-3-Benzazepine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDopamine Agonists - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Dopamine D1 - Agonistsen_US
dc.subject.meshStartle Reaction - Drug Effectsen_US
dc.titleThe paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigmen_US
dc.typeArticleen_US
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_US
dc.identifier.authorityZhang, ZJ=rp01297en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neulet.2005.03.001en_US
dc.identifier.pmid15911136-
dc.identifier.scopuseid_2-s2.0-19444364640en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19444364640&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume382en_US
dc.identifier.issue1-2en_US
dc.identifier.spage134en_US
dc.identifier.epage138en_US
dc.identifier.isiWOS:000229661900026-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_US
dc.identifier.scopusauthoridJiang, XL=7404627223en_US
dc.identifier.scopusauthoridZhang, SE=8501891300en_US
dc.identifier.scopusauthoridHough, CJ=7006745572en_US
dc.identifier.scopusauthoridLi, H=8133759400en_US
dc.identifier.scopusauthoridChen, JG=36050815400en_US
dc.identifier.scopusauthoridZhen, XC=16246797700en_US

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