File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats

TitleThe benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats
Authors
Issue Date2002
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2002, v. 329 n. 3, p. 253-256 How to Cite?
AbstractRo15-4513 (ethyl-8-azido-5,6-dihydro-5methyl-6-oxo-4H-imidazo-[1,5-a]-1,4- benzodiazepine-3-carboxylate), a benzodiazepine partial inverse agonist of the GABAA receptor, is known to protect against alcohol toxicities. The present study was designed to determine the role of Ro15-4513 in preventing anticonvulsant, toxic, and lethal effects of carbamazepine (CBZ) in amygdala-kindled rats. Acute treatment with CBZ (25 mg/kg, i.p.) produced anticonvulsant effects in fully kindled rats characterized by a significant decrease in afterdischarge and seizure duration and stage. Repeated administration of this high dose of CBZ induced sedation and high (56%) lethality. The anticonvulsant and sedative effects of CBZ were strikingly suppressed by pretreatment with Ro15-4513 (2.5 and 5 mg/kg, i.p.), and there was no mortality in animals co-administrated with Ro15-4513 during the entire experimental period. These results indicate that Ro15-4513 protects against CBZ-induced sedation and lethality, while suppressing the anticonvulsant effects of CBZ, suggesting a role for the GABAA receptor in CBZ efficacy and side effects. The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored. © 2002 Published by Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179414
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorPostma, Ten_US
dc.contributor.authorObeng, Ken_US
dc.contributor.authorRussell, Sen_US
dc.contributor.authorWeiss, SRBen_US
dc.contributor.authorPost, RMen_US
dc.date.accessioned2012-12-19T09:56:17Z-
dc.date.available2012-12-19T09:56:17Z-
dc.date.issued2002en_US
dc.identifier.citationNeuroscience Letters, 2002, v. 329 n. 3, p. 253-256en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/179414-
dc.description.abstractRo15-4513 (ethyl-8-azido-5,6-dihydro-5methyl-6-oxo-4H-imidazo-[1,5-a]-1,4- benzodiazepine-3-carboxylate), a benzodiazepine partial inverse agonist of the GABAA receptor, is known to protect against alcohol toxicities. The present study was designed to determine the role of Ro15-4513 in preventing anticonvulsant, toxic, and lethal effects of carbamazepine (CBZ) in amygdala-kindled rats. Acute treatment with CBZ (25 mg/kg, i.p.) produced anticonvulsant effects in fully kindled rats characterized by a significant decrease in afterdischarge and seizure duration and stage. Repeated administration of this high dose of CBZ induced sedation and high (56%) lethality. The anticonvulsant and sedative effects of CBZ were strikingly suppressed by pretreatment with Ro15-4513 (2.5 and 5 mg/kg, i.p.), and there was no mortality in animals co-administrated with Ro15-4513 during the entire experimental period. These results indicate that Ro15-4513 protects against CBZ-induced sedation and lethality, while suppressing the anticonvulsant effects of CBZ, suggesting a role for the GABAA receptor in CBZ efficacy and side effects. The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored. © 2002 Published by Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAffinity Labels - Pharmacologyen_US
dc.subject.meshAmygdala - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants - Toxicityen_US
dc.subject.meshAzides - Pharmacologyen_US
dc.subject.meshBenzodiazepines - Pharmacologyen_US
dc.subject.meshCarbamazepine - Toxicityen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEpilepsy - Drug Therapy - Mortality - Physiopathologyen_US
dc.subject.meshGaba-A Receptor Agonistsen_US
dc.subject.meshKindling, Neurologic - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleThe benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled ratsen_US
dc.typeArticleen_US
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_US
dc.identifier.authorityZhang, ZJ=rp01297en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3940(02)00664-Xen_US
dc.identifier.pmid12183024-
dc.identifier.scopuseid_2-s2.0-0037031571en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037031571&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume329en_US
dc.identifier.issue3en_US
dc.identifier.spage253en_US
dc.identifier.epage256en_US
dc.identifier.isiWOS:000178104400001-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_US
dc.identifier.scopusauthoridPostma, T=7003610812en_US
dc.identifier.scopusauthoridObeng, K=6701594477en_US
dc.identifier.scopusauthoridRussell, S=7401538133en_US
dc.identifier.scopusauthoridWeiss, SRB=35448419700en_US
dc.identifier.scopusauthoridPost, RM=7202218145en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats