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Article: Mechanisms of yiqi tongluo pill on oxygen free radicals, nitric oxide and fibrinolysis in coronary heart diseases and hypertension patients

TitleMechanisms of yiqi tongluo pill on oxygen free radicals, nitric oxide and fibrinolysis in coronary heart diseases and hypertension patients
Authors
Issue Date1997
PublisherZhongguo Zhong-Xiyi Jiehe Zazhi. The Journal's web site is located at http://zxyjh.periodicals.net.cn/
Citation
Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal Of Integrated Traditional And Western Medicine / Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban, 1997, v. 17 n. 7, p. 410-413 How to Cite?
AbstractOBJECTIVE: To clarify the mechanism of Yiqi Tongluo Pill (YQTLP) in treating coronary heart disease and hypertension. METHODS: The clinical effects of YQTLP on 97 coronary heart diseases (CHD) and hypertension patients, in comparing to the 92 patients treated with nitroglycerin was investigated. The changes of plasma lipid peroxide (LPO), superoxide dismutase (SOD), tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and nitric oxide (NO) were observed in the patients treated with YQTLP and nitroglycerin, which were compared to 30 healthy subjects. RESULTS: The levels of LPO and PAI increased and the levels of SOD, t-PA and NO decreased significantly in the patients. The clinical effects of YQTLP were better than that of nitroglycerin in the patients with unstable angina, while the effects of YQTLP were worse than that of nitroglycerin in the patients of hypertension and hypertension with CHD. YQTLP could decrease the levels of LPO and PAI and increase the levels of SOD, t-PA and NO significantly. The effects of YQTLP on t-PA and SOD were better than that of nitroglycerin. CONCLUSION: The protective mechanisms of YQTLP were related to inhibit lipid peroxidation, protect endothelium-derived relaxing factor and adjust the fibrinolytic activities.
Persistent Identifierhttp://hdl.handle.net/10722/179401
ISSN
2015 SCImago Journal Rankings: 0.140

 

DC FieldValueLanguage
dc.contributor.authorShen, JGen_US
dc.contributor.authorGuo, ZGen_US
dc.contributor.authorTong, Len_US
dc.date.accessioned2012-12-19T09:56:11Z-
dc.date.available2012-12-19T09:56:11Z-
dc.date.issued1997en_US
dc.identifier.citationZhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal Of Integrated Traditional And Western Medicine / Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban, 1997, v. 17 n. 7, p. 410-413en_US
dc.identifier.issn1003-5370en_US
dc.identifier.urihttp://hdl.handle.net/10722/179401-
dc.description.abstractOBJECTIVE: To clarify the mechanism of Yiqi Tongluo Pill (YQTLP) in treating coronary heart disease and hypertension. METHODS: The clinical effects of YQTLP on 97 coronary heart diseases (CHD) and hypertension patients, in comparing to the 92 patients treated with nitroglycerin was investigated. The changes of plasma lipid peroxide (LPO), superoxide dismutase (SOD), tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and nitric oxide (NO) were observed in the patients treated with YQTLP and nitroglycerin, which were compared to 30 healthy subjects. RESULTS: The levels of LPO and PAI increased and the levels of SOD, t-PA and NO decreased significantly in the patients. The clinical effects of YQTLP were better than that of nitroglycerin in the patients with unstable angina, while the effects of YQTLP were worse than that of nitroglycerin in the patients of hypertension and hypertension with CHD. YQTLP could decrease the levels of LPO and PAI and increase the levels of SOD, t-PA and NO significantly. The effects of YQTLP on t-PA and SOD were better than that of nitroglycerin. CONCLUSION: The protective mechanisms of YQTLP were related to inhibit lipid peroxidation, protect endothelium-derived relaxing factor and adjust the fibrinolytic activities.en_US
dc.languageengen_US
dc.publisherZhongguo Zhong-Xiyi Jiehe Zazhi. The Journal's web site is located at http://zxyjh.periodicals.net.cn/en_US
dc.relation.ispartofZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu banen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCoronary Disease - Blood - Drug Therapyen_US
dc.subject.meshDrugs, Chinese Herbal - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolysis - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Blood - Drug Therapyen_US
dc.subject.meshLipid Peroxides - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNitric Oxide - Blooden_US
dc.subject.meshSuperoxide Dismutase - Blooden_US
dc.subject.meshTissue Plasminogen Activator - Blooden_US
dc.titleMechanisms of yiqi tongluo pill on oxygen free radicals, nitric oxide and fibrinolysis in coronary heart diseases and hypertension patientsen_US
dc.typeArticleen_US
dc.identifier.emailShen, JG: shenjg@hku.hken_US
dc.identifier.authorityShen, JG=rp00487en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10322861-
dc.identifier.scopuseid_2-s2.0-0031173429en_US
dc.identifier.volume17en_US
dc.identifier.issue7en_US
dc.identifier.spage410en_US
dc.identifier.epage413en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridShen, JG=7404929947en_US
dc.identifier.scopusauthoridGuo, ZG=39561207200en_US
dc.identifier.scopusauthoridTong, L=7201891650en_US

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