File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Synergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium - ESR studies on NO free radicals generated from ischemia-reperfused myocardium

TitleSynergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium - ESR studies on NO free radicals generated from ischemia-reperfused myocardium
Authors
KeywordsEsr
Ischemia-Reperfusion Injury Of Myocardium
No
O 2
Issue Date1996
Publisher中國科學院. The Journal's web site is located at http://jcxg.chinajournal.net.cn/
Citation
Science In China, Series C: Life Sciences, 1996, v. 39 n. 5, p. 491-500 How to Cite?
AbstractThe ESR signal of NO bound to hemoglobin was detected during the ischemia-reperfusion of myocardium with low temperature ESR technique, and the synergic effects of NO and oxygen free radicals in the injury of the process were studied with this technique. Oxygen free radicals and NO bound to β-subunit of hemoglobin (β-NO complex) could be detected simultaneously in the ischemia-reperfused myocardium. Those signals could not be detected from the normal myocardium even in the presence of L-arginine. However, those signals could be detected and were dose-dependent with L-arginine in the ischemia-reperfused myocardiums and the signal could be suppressed with the inhibitor of NO synthetase, N G-nitro-L-arginine methylester (NAME). Measurement of the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart showed that L-arginine at lower concentration (<1 mmol/L) could protect the heart from the ischemia-reperfusion injury but at higher concentration aggravate the injury Addition of NAME to the reperfusion solution could also protect the myocardium. Addition of xanthine (X)/xanthine oxidase (XO) or Fe 2+/H 2O 2 to the reperfusion solution increased the production of NO and oxygen free radicals and the ischemia-reperfused injury simultaneously. Addition of superoxide dismutase (SOD) and catalase decreased the production of NO and oxygen free radicals and the ischemia-reperfusion injury.
Persistent Identifierhttp://hdl.handle.net/10722/179400
ISSN
2011 Impact Factor: 1.61
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, Ben_US
dc.contributor.authorShen, Jen_US
dc.contributor.authorHu, Jen_US
dc.contributor.authorWan, Qen_US
dc.contributor.authorXin, Wen_US
dc.date.accessioned2012-12-19T09:56:11Z-
dc.date.available2012-12-19T09:56:11Z-
dc.date.issued1996en_US
dc.identifier.citationScience In China, Series C: Life Sciences, 1996, v. 39 n. 5, p. 491-500en_US
dc.identifier.issn1006-9305en_US
dc.identifier.urihttp://hdl.handle.net/10722/179400-
dc.description.abstractThe ESR signal of NO bound to hemoglobin was detected during the ischemia-reperfusion of myocardium with low temperature ESR technique, and the synergic effects of NO and oxygen free radicals in the injury of the process were studied with this technique. Oxygen free radicals and NO bound to β-subunit of hemoglobin (β-NO complex) could be detected simultaneously in the ischemia-reperfused myocardium. Those signals could not be detected from the normal myocardium even in the presence of L-arginine. However, those signals could be detected and were dose-dependent with L-arginine in the ischemia-reperfused myocardiums and the signal could be suppressed with the inhibitor of NO synthetase, N G-nitro-L-arginine methylester (NAME). Measurement of the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart showed that L-arginine at lower concentration (<1 mmol/L) could protect the heart from the ischemia-reperfusion injury but at higher concentration aggravate the injury Addition of NAME to the reperfusion solution could also protect the myocardium. Addition of xanthine (X)/xanthine oxidase (XO) or Fe 2+/H 2O 2 to the reperfusion solution increased the production of NO and oxygen free radicals and the ischemia-reperfused injury simultaneously. Addition of superoxide dismutase (SOD) and catalase decreased the production of NO and oxygen free radicals and the ischemia-reperfusion injury.en_US
dc.languageengen_US
dc.publisher中國科學院. The Journal's web site is located at http://jcxg.chinajournal.net.cn/en_US
dc.relation.ispartofScience in China, Series C: Life Sciencesen_US
dc.subjectEsren_US
dc.subjectIschemia-Reperfusion Injury Of Myocardiumen_US
dc.subjectNoen_US
dc.subjectO 2en_US
dc.titleSynergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium - ESR studies on NO free radicals generated from ischemia-reperfused myocardiumen_US
dc.typeArticleen_US
dc.identifier.emailShen, J: shenjg@hku.hken_US
dc.identifier.authorityShen, J=rp00487en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0030251771en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030251771&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue5en_US
dc.identifier.spage491en_US
dc.identifier.epage500en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridZhao, B=7403058931en_US
dc.identifier.scopusauthoridShen, J=7404929947en_US
dc.identifier.scopusauthoridHu, J=7406416241en_US
dc.identifier.scopusauthoridWan, Q=8891428800en_US
dc.identifier.scopusauthoridXin, W=7102977683en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats