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Article: Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion

TitleScavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion
Authors
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadis
Citation
Biochimica Et Biophysica Acta - Molecular Basis Of Disease, 1996, v. 1315 n. 2, p. 131-137 How to Cite?
AbstractThe scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on myocardium from the ischemia-reperfusion injury was studied with electron spin resonance (ESR) and chemiluminescence techniques. Chinonin can effectively inhibit the oxidative activity of ONOO-, (the IC50 =7 X 10-5 mmol/L) and scavenge oxygen free radicals generated from the reaction of xanthine and xanthine oxidase (the IC50 = 2.5 X 10-4 mmol/l). It is difficult to find another antioxidant which can scavenge so effectively both ONOO- and oxygen free radicals simultaneously. In the system of ischemia-reperfusion injury of myocardium, Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated from the ischemia-reperfused myocardium, and decrease the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart and therefore protect the heart from ischemia-reperfusion injury. The protective effect of 0.1 mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase.
Persistent Identifierhttp://hdl.handle.net/10722/179399
ISSN
2015 Impact Factor: 5.158
2015 SCImago Journal Rankings: 2.718
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, BLen_US
dc.contributor.authorShen, JGen_US
dc.contributor.authorLi, Men_US
dc.contributor.authorLi, MFen_US
dc.contributor.authorWan, Qen_US
dc.contributor.authorXin, WJen_US
dc.date.accessioned2012-12-19T09:56:10Z-
dc.date.available2012-12-19T09:56:10Z-
dc.date.issued1996en_US
dc.identifier.citationBiochimica Et Biophysica Acta - Molecular Basis Of Disease, 1996, v. 1315 n. 2, p. 131-137en_US
dc.identifier.issn0925-4439en_US
dc.identifier.urihttp://hdl.handle.net/10722/179399-
dc.description.abstractThe scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on myocardium from the ischemia-reperfusion injury was studied with electron spin resonance (ESR) and chemiluminescence techniques. Chinonin can effectively inhibit the oxidative activity of ONOO-, (the IC50 =7 X 10-5 mmol/L) and scavenge oxygen free radicals generated from the reaction of xanthine and xanthine oxidase (the IC50 = 2.5 X 10-4 mmol/l). It is difficult to find another antioxidant which can scavenge so effectively both ONOO- and oxygen free radicals simultaneously. In the system of ischemia-reperfusion injury of myocardium, Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated from the ischemia-reperfused myocardium, and decrease the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart and therefore protect the heart from ischemia-reperfusion injury. The protective effect of 0.1 mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/bbadisen_US
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Diseaseen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshCatalase - Pharmacologyen_US
dc.subject.meshElectron Spin Resonance Spectroscopyen_US
dc.subject.meshEnzyme Inhibitors - Pharmacologyen_US
dc.subject.meshFree Radical Scavengers - Pharmacologyen_US
dc.subject.meshFree Radicals - Metabolismen_US
dc.subject.meshGlycosides - Pharmacologyen_US
dc.subject.meshHeart - Drug Effects - Physiology - Physiopathologyen_US
dc.subject.meshHemoglobins - Metabolismen_US
dc.subject.meshKineticsen_US
dc.subject.meshLuminescent Measurementsen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Ischemia - Metabolism - Prevention & Controlen_US
dc.subject.meshMyocardial Reperfusion Injury - Metabolism - Prevention & Controlen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshNg-Nitroarginine Methyl Esteren_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitric Oxide Synthase - Antagonists & Inhibitorsen_US
dc.subject.meshOxidation-Reductionen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshXanthenes - Pharmacologyen_US
dc.subject.meshXanthine Oxidase - Metabolismen_US
dc.titleScavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusionen_US
dc.typeArticleen_US
dc.identifier.emailShen, JG: shenjg@hku.hken_US
dc.identifier.authorityShen, JG=rp00487en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0925-4439(95)00112-3en_US
dc.identifier.pmid8608170-
dc.identifier.scopuseid_2-s2.0-0029988539en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029988539&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1315en_US
dc.identifier.issue2en_US
dc.identifier.spage131en_US
dc.identifier.epage137en_US
dc.identifier.isiWOS:A1996TY94500009-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhao, BL=7403058931en_US
dc.identifier.scopusauthoridShen, JG=7404929947en_US
dc.identifier.scopusauthoridLi, M=36066390600en_US
dc.identifier.scopusauthoridLi, MF=7405263394en_US
dc.identifier.scopusauthoridWan, Q=8891428800en_US
dc.identifier.scopusauthoridXin, WJ=7102977683en_US

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