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Article: Efficiency of ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury

TitleEfficiency of ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury
Authors
Issue Date1995
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/15216543.asp
Citation
Biochemistry And Molecular Biology International, 1995, v. 35 n. 1, p. 125-134 How to Cite?
AbstractThe cardio-protective mechanisms of EGb 761, an extract of Ginkgo biloba leaves, on myocardial ischemia reperfusion injury were investigated using rabbits subjected to 30 minutes of regional cardiac ischemia and 120 min of reperfusion under anesthesia. Compared to the saline perfused group, EGb 761 treatment (10 mg/kg, injected into the coronary artery) significantly inhibited the increase in lipid peroxidation and maintained total and CuZn-SOD levels in both plasma and tissue during and at the end of reperfusion. Both the decrease in tissue type plasminogen activator (t-PA) and the increase in plasminogen activator inhibitor-1 (PAI-1) caused by ischemia-reperfusion were also significantly suppressed by EGb 761 treatment. Furthermore, the ultrastructure of the myocytes of the EGb 761 treated heart was slightly damaged after ischemia-reperfusion, while the control ischemic-reperfused hearts demonstrated severe histological damages such as swelling and vacuolization of the mitochondria. These results suggest that EGb 761 protects hearts by its antioxidant properties and by its ability to adjust fibrinolytic activity.
Persistent Identifierhttp://hdl.handle.net/10722/179398
ISSN
2001 Impact Factor: 0.925
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShen, JGen_US
dc.contributor.authorZhou, DYen_US
dc.date.accessioned2012-12-19T09:56:10Z-
dc.date.available2012-12-19T09:56:10Z-
dc.date.issued1995en_US
dc.identifier.citationBiochemistry And Molecular Biology International, 1995, v. 35 n. 1, p. 125-134en_US
dc.identifier.issn1039-9712en_US
dc.identifier.urihttp://hdl.handle.net/10722/179398-
dc.description.abstractThe cardio-protective mechanisms of EGb 761, an extract of Ginkgo biloba leaves, on myocardial ischemia reperfusion injury were investigated using rabbits subjected to 30 minutes of regional cardiac ischemia and 120 min of reperfusion under anesthesia. Compared to the saline perfused group, EGb 761 treatment (10 mg/kg, injected into the coronary artery) significantly inhibited the increase in lipid peroxidation and maintained total and CuZn-SOD levels in both plasma and tissue during and at the end of reperfusion. Both the decrease in tissue type plasminogen activator (t-PA) and the increase in plasminogen activator inhibitor-1 (PAI-1) caused by ischemia-reperfusion were also significantly suppressed by EGb 761 treatment. Furthermore, the ultrastructure of the myocytes of the EGb 761 treated heart was slightly damaged after ischemia-reperfusion, while the control ischemic-reperfused hearts demonstrated severe histological damages such as swelling and vacuolization of the mitochondria. These results suggest that EGb 761 protects hearts by its antioxidant properties and by its ability to adjust fibrinolytic activity.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/15216543.aspen_US
dc.relation.ispartofBiochemistry and Molecular Biology Internationalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidantsen_US
dc.subject.meshFree Radical Scavengers - Pharmacologyen_US
dc.subject.meshGinkgo Bilobaen_US
dc.subject.meshLipid Peroxides - Analysis - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMitochondria - Physiologyen_US
dc.subject.meshMyocardial Ischemia - Drug Therapyen_US
dc.subject.meshMyocardial Reperfusion Injury - Drug Therapyen_US
dc.subject.meshMyocardium - Chemistry - Cytology - Pathologyen_US
dc.subject.meshPlant Extracts - Pharmacologyen_US
dc.subject.meshPlasminogen - Pharmacokineticsen_US
dc.subject.meshPlasminogen Activator Inhibitor 1 - Pharmacokineticsen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSuperoxide Dismutase - Analysis - Blooden_US
dc.subject.meshTime Factorsen_US
dc.titleEfficiency of ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injuryen_US
dc.typeArticleen_US
dc.identifier.emailShen, JG: shenjg@hku.hken_US
dc.identifier.authorityShen, JG=rp00487en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7735127-
dc.identifier.scopuseid_2-s2.0-0028952830en_US
dc.identifier.volume35en_US
dc.identifier.issue1en_US
dc.identifier.spage125en_US
dc.identifier.epage134en_US
dc.identifier.isiWOS:A1995QF68700015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridShen, JG=7404929947en_US
dc.identifier.scopusauthoridZhou, DY=7403395166en_US

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