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Article: Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women

TitleCharacterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women
Authors
Issue Date2012
Citation
Food Additives And Contaminants - Part A Chemistry, Analysis, Control, Exposure And Risk Assessment, 2012, v. 29 n. 6, p. 962-971 How to Cite?
AbstractMycotoxins such as the aflatoxins and deoxynivalenol (DON) are frequent contaminants of food. Aflatoxin B1 (AFB1) and DON affect the immune system and restrict growth; additionally AFB1 is carcinogenic. To date there are limited descriptive biomarker data concerning maternal exposures during pregnancy, and none on co-exposures to these mycotoxins. This survey was a cross-sectional assessment providing descriptive data on the concentrations of serum aflatoxin-albumin (AF-alb), urinary aflatoxin M1 (AFM1), and urinary DON for 98 pregnant women from Egypt, in relation to diet and socioeconomic status, during the third trimester. AF-alb was detected in 34 of 98 (35%) samples, geometric mean (GM) of positives = 4.9 pg AF-lys mg -1 albumin (95% confidence interval (CI) = 4.1-5.8 pg mg -1), and AFM1 in 44 of 93 (48%) samples, GM of positives = 19.7 pg mg -1 creatinine (95%CI = 14.8-26.3 pg mg -1). AF-alb and AFM1 levels were positively correlated (R = 0.276, p = 0.007). DON was detected in 63 of 93 (68%), GM of positives = 2.8 ng mg -1 (95%CI = 2.1-3.6 ng mg -1). Aflatoxin and DON biomarkers were observed in 41% of the subjects concurrently. The frequency and level of these biomarkers in Egyptian women were modest compared with known high-risk countries. However, this study represents the first biomarker survey to report on the occurrence of DON biomarkers in an African population, in addition to the co-occurrence of these two potent mycotoxins. This combined exposure may be of particular concern during pregnancy given the potential of toxin transfer to the foetus. © 2012 Copyright Taylor and Francis Group, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/179277
ISSN
2015 Impact Factor: 1.878
2015 SCImago Journal Rankings: 0.756
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPiekkola, Sen_US
dc.contributor.authorTurner, PCen_US
dc.contributor.authorAbdelHamid, Men_US
dc.contributor.authorEzzat, Sen_US
dc.contributor.authorElDaly, Men_US
dc.contributor.authorElKafrawy, Sen_US
dc.contributor.authorSavchenko, Een_US
dc.contributor.authorPoussa, Ten_US
dc.contributor.authorWoo, JCSen_US
dc.contributor.authorMykkänen, Hen_US
dc.contributor.authorElNezami, Hen_US
dc.date.accessioned2012-12-19T09:53:37Z-
dc.date.available2012-12-19T09:53:37Z-
dc.date.issued2012en_US
dc.identifier.citationFood Additives And Contaminants - Part A Chemistry, Analysis, Control, Exposure And Risk Assessment, 2012, v. 29 n. 6, p. 962-971en_US
dc.identifier.issn1944-0049en_US
dc.identifier.urihttp://hdl.handle.net/10722/179277-
dc.description.abstractMycotoxins such as the aflatoxins and deoxynivalenol (DON) are frequent contaminants of food. Aflatoxin B1 (AFB1) and DON affect the immune system and restrict growth; additionally AFB1 is carcinogenic. To date there are limited descriptive biomarker data concerning maternal exposures during pregnancy, and none on co-exposures to these mycotoxins. This survey was a cross-sectional assessment providing descriptive data on the concentrations of serum aflatoxin-albumin (AF-alb), urinary aflatoxin M1 (AFM1), and urinary DON for 98 pregnant women from Egypt, in relation to diet and socioeconomic status, during the third trimester. AF-alb was detected in 34 of 98 (35%) samples, geometric mean (GM) of positives = 4.9 pg AF-lys mg -1 albumin (95% confidence interval (CI) = 4.1-5.8 pg mg -1), and AFM1 in 44 of 93 (48%) samples, GM of positives = 19.7 pg mg -1 creatinine (95%CI = 14.8-26.3 pg mg -1). AF-alb and AFM1 levels were positively correlated (R = 0.276, p = 0.007). DON was detected in 63 of 93 (68%), GM of positives = 2.8 ng mg -1 (95%CI = 2.1-3.6 ng mg -1). Aflatoxin and DON biomarkers were observed in 41% of the subjects concurrently. The frequency and level of these biomarkers in Egyptian women were modest compared with known high-risk countries. However, this study represents the first biomarker survey to report on the occurrence of DON biomarkers in an African population, in addition to the co-occurrence of these two potent mycotoxins. This combined exposure may be of particular concern during pregnancy given the potential of toxin transfer to the foetus. © 2012 Copyright Taylor and Francis Group, LLC.en_US
dc.languageengen_US
dc.relation.ispartofFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessmenten_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAflatoxin B1 - Urineen_US
dc.subject.meshBiological Markers - Urineen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEgypten_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshFemaleen_US
dc.subject.meshFood Contaminationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaternal Exposureen_US
dc.subject.meshPregnancyen_US
dc.subject.meshTrichothecenes - Urineen_US
dc.subject.meshYoung Adulten_US
dc.titleCharacterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian womenen_US
dc.typeArticleen_US
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_US
dc.identifier.authorityElNezami, H=rp00694en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/19440049.2012.658442en_US
dc.identifier.pmid22376138-
dc.identifier.scopuseid_2-s2.0-84860910418en_US
dc.identifier.hkuros203975-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860910418&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.spage962en_US
dc.identifier.epage971en_US
dc.identifier.eissn1944-0057-
dc.identifier.isiWOS:000303585900011-
dc.identifier.scopusauthoridPiekkola, S=23973588700en_US
dc.identifier.scopusauthoridTurner, PC=7402096074en_US
dc.identifier.scopusauthoridAbdelHamid, M=7005355084en_US
dc.identifier.scopusauthoridEzzat, S=8644074300en_US
dc.identifier.scopusauthoridElDaly, M=12545568200en_US
dc.identifier.scopusauthoridElKafrawy, S=12545932500en_US
dc.identifier.scopusauthoridSavchenko, E=55215605900en_US
dc.identifier.scopusauthoridPoussa, T=6701796915en_US
dc.identifier.scopusauthoridWoo, JCS=55215264300en_US
dc.identifier.scopusauthoridMykkänen, H=36010950800en_US
dc.identifier.scopusauthoridElNezami, H=6603690577en_US

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