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Article: Estrogenic potential of benzotriazole on marine medaka (Oryzias melastigma)

TitleEstrogenic potential of benzotriazole on marine medaka (Oryzias melastigma)
Authors
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ecoenv
Citation
Ecotoxicology And Environmental Safety, 2012, v. 80, p. 327-332 How to Cite?
AbstractThis study, for the first time, assessed the reproductive effects of benzotriazoles, widely used industrial chemicals, on marine fish. Marine medakas (Oryzias melastigma) were exposed to 0.01, 0.1, and 1. mg/L benzotriazole for periods of four and 35 days. The results that are obtained showed that the expression levels of CYP1A1 were down-regulated in the liver, gills and intestines of both males and females. Vitellogenin (VTG) was highly induced in the liver, gills and intestine of both male and female marine medaka, and CYP19a was up-regulated in the ovaries especially after being exposed for 35 days. Most importantly, the results of the present study suggest that even at environmentally relevant concentrations detected in the aquatic environment, 0.01. mg/L, benzotriazole also caused notable changes in expression levels of VTG, CYP1A1 and CYP19a. More concerns about the toxicity of benzotriazoles on marine animals should be raised. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/179276
ISSN
2015 Impact Factor: 3.13
2015 SCImago Journal Rankings: 1.229
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTangtian, Hen_US
dc.contributor.authorBo, Len_US
dc.contributor.authorWenhua, Len_US
dc.contributor.authorShin, PKSen_US
dc.contributor.authorWu, RSSen_US
dc.date.accessioned2012-12-19T09:53:36Z-
dc.date.available2012-12-19T09:53:36Z-
dc.date.issued2012en_US
dc.identifier.citationEcotoxicology And Environmental Safety, 2012, v. 80, p. 327-332en_US
dc.identifier.issn0147-6513en_US
dc.identifier.urihttp://hdl.handle.net/10722/179276-
dc.description.abstractThis study, for the first time, assessed the reproductive effects of benzotriazoles, widely used industrial chemicals, on marine fish. Marine medakas (Oryzias melastigma) were exposed to 0.01, 0.1, and 1. mg/L benzotriazole for periods of four and 35 days. The results that are obtained showed that the expression levels of CYP1A1 were down-regulated in the liver, gills and intestines of both males and females. Vitellogenin (VTG) was highly induced in the liver, gills and intestine of both male and female marine medaka, and CYP19a was up-regulated in the ovaries especially after being exposed for 35 days. Most importantly, the results of the present study suggest that even at environmentally relevant concentrations detected in the aquatic environment, 0.01. mg/L, benzotriazole also caused notable changes in expression levels of VTG, CYP1A1 and CYP19a. More concerns about the toxicity of benzotriazoles on marine animals should be raised. © 2012 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ecoenven_US
dc.relation.ispartofEcotoxicology and Environmental Safetyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCytochrome P-450 Cyp1a1 - Metabolismen_US
dc.subject.meshEndocrine Disruptors - Toxicityen_US
dc.subject.meshEnvironmental Pollutants - Toxicityen_US
dc.subject.meshEstrogens - Toxicityen_US
dc.subject.meshFemaleen_US
dc.subject.meshGills - Drug Effects - Metabolismen_US
dc.subject.meshLiver - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshOryziasen_US
dc.subject.meshOvary - Drug Effects - Metabolismen_US
dc.subject.meshReproduction - Drug Effectsen_US
dc.subject.meshTriazoles - Toxicityen_US
dc.subject.meshVitellogenins - Metabolism - Pharmacologyen_US
dc.titleEstrogenic potential of benzotriazole on marine medaka (Oryzias melastigma)en_US
dc.typeArticleen_US
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_US
dc.identifier.authorityWu, RSS=rp01398en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ecoenv.2012.03.020en_US
dc.identifier.pmid22521813-
dc.identifier.scopuseid_2-s2.0-84860539323en_US
dc.identifier.hkuros208749-
dc.identifier.hkuros203331-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860539323&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume80en_US
dc.identifier.spage327en_US
dc.identifier.epage332en_US
dc.identifier.isiWOS:000304337300047-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTangtian, H=55188519600en_US
dc.identifier.scopusauthoridBo, L=55188430300en_US
dc.identifier.scopusauthoridWenhua, L=55188806300en_US
dc.identifier.scopusauthoridShin, PKS=7004445653en_US
dc.identifier.scopusauthoridWu, RSS=7402945079en_US
dc.identifier.citeulike10604408-

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