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Conference Paper: Extragastrointestinal functions and transcriptional regulation of secretin and secretin receptors

TitleExtragastrointestinal functions and transcriptional regulation of secretin and secretin receptors
Authors
Issue Date2011
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
The 7th International Congress of Neuroendocrinology, Rouen, France, 11-15 July 2010. In Annals Of The New York Academy Of Sciences, 2011, v. 1220 n. 1, p. 23-33 How to Cite?
AbstractThe functional role of secretin outside the gastrointestinal system has been a mystery to endocrinologists for many years. With the availability of secretin- and secretin receptor-knockout models and the advances of electrophysiological and immunohistochemical techniques, we are now in a good position to explore the functions of secretin outside the gastrointestinal system. There is growing evidence to support that secretin works pleiotropically at multiple levels in our body. In this paper, we review the recent findings regarding the physiological effects of secretin on extragastrointestinal sites including the cerebellum, the hippocampus, and the hypothalamus-pituitary-kidney axis. To understand the mechanisms underlying the site-specific expression of secretin and secretin receptors in the central nervous system, we also discuss the transcriptional regulation of secretin and secretin receptor genes in neuronal cell lines. © 2011 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/179224
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Yen_US
dc.contributor.authorLee, LTOen_US
dc.contributor.authorNg, SSen_US
dc.contributor.authorChow, BKCen_US
dc.date.accessioned2012-12-19T09:53:12Z-
dc.date.available2012-12-19T09:53:12Z-
dc.date.issued2011en_US
dc.identifier.citationThe 7th International Congress of Neuroendocrinology, Rouen, France, 11-15 July 2010. In Annals Of The New York Academy Of Sciences, 2011, v. 1220 n. 1, p. 23-33en_US
dc.identifier.issn0077-8923en_US
dc.identifier.urihttp://hdl.handle.net/10722/179224-
dc.description.abstractThe functional role of secretin outside the gastrointestinal system has been a mystery to endocrinologists for many years. With the availability of secretin- and secretin receptor-knockout models and the advances of electrophysiological and immunohistochemical techniques, we are now in a good position to explore the functions of secretin outside the gastrointestinal system. There is growing evidence to support that secretin works pleiotropically at multiple levels in our body. In this paper, we review the recent findings regarding the physiological effects of secretin on extragastrointestinal sites including the cerebellum, the hippocampus, and the hypothalamus-pituitary-kidney axis. To understand the mechanisms underlying the site-specific expression of secretin and secretin receptors in the central nervous system, we also discuss the transcriptional regulation of secretin and secretin receptor genes in neuronal cell lines. © 2011 New York Academy of Sciences.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshReceptors, G-Protein-Coupled - Geneticsen_US
dc.subject.meshReceptors, Gastrointestinal Hormone - Geneticsen_US
dc.subject.meshSecretin - Geneticsen_US
dc.subject.meshTranscription, Geneticen_US
dc.titleExtragastrointestinal functions and transcriptional regulation of secretin and secretin receptorsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_US
dc.identifier.emailNg, SS: ssmng@hku.hken_US
dc.identifier.emailChow, BKC: bkcc@hku.hken_US
dc.identifier.authorityLee, LTO=rp00727en_US
dc.identifier.authorityNg, SS=rp00767en_US
dc.identifier.authorityChow, BKC=rp00681en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1749-6632.2011.05987.xen_US
dc.identifier.pmid21388401-
dc.identifier.scopuseid_2-s2.0-79952471899en_US
dc.identifier.hkuros185540-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952471899&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1220en_US
dc.identifier.issue1en_US
dc.identifier.spage23en_US
dc.identifier.epage33en_US
dc.identifier.isiWOS:000293198000004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYuan, Y=55474939100en_US
dc.identifier.scopusauthoridLee, LTO=8367269000en_US
dc.identifier.scopusauthoridNg, SS=7403358718en_US
dc.identifier.scopusauthoridChow, BKC=7102826193en_US
dc.identifier.citeulike8982894-

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